---
title: Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure at Different Intensities
nct_id: NCT05730166
overall_status: COMPLETED
phase: NA
sponsor: Josue Fernandez Carnero
study_type: INTERVENTIONAL
primary_condition: Healthy
countries: Spain
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05730166.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05730166"
ct_last_update_post_date: 2023-05-12
last_seen_at: "2026-05-12T07:08:27.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure at Different Intensities

**Official Title:** Conditioned Pain Modulation Induced by Mechanical Stimulation. A Mechanism of Manual Therapy Analgesia: Study 2

**NCT ID:** [NCT05730166](https://clinicaltrials.gov/study/NCT05730166)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 24
- **Lead Sponsor:** Josue Fernandez Carnero
- **Conditions:** Healthy
- **Start Date:** 2023-02-15
- **Completion Date:** 2023-04-21
- **CT.gov Last Update:** 2023-05-12

## Brief Summary

The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius at moderate intensity compared to mild intensity or non-painful.

## Detailed Description

The mechanical stimulus produced in manual therapy (MT) techniques elicits neurophysiological responses within the peripheral and central nervous system responsible for pain inhibition. Almost all types of MT elicit a neurophysiological response that is associated with the descending pain modulation circuit. But it has not been demonstrated whether this inhibition occurs through a conditioned pain modulation mechanism induced by painful mechanical stimulation that is carried out with manual therapy techniques.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 65 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* healthy male or female between 18 and 65 years
* Free of pain and with no history of chronic pain

Exclusion Criteria:

* Pregnant or having given birth within the last year
```

## Arms

- **Mechanical stimulation at moderate pain intensity** (EXPERIMENTAL) — Mechanical compression is applied with the thumb to the upper trapezius muscle on the non-dominant side at the midpoint between the acromion and C7. The intensity of this will be regulated by the pain it causes the patient, trying to ensure that it is at all times approximately 5/10 on the numerical pain rating scale (NPRS) with 0 being "no pain at all" and 10 being "the worst pain imaginable". The stimulation will be carried out for 2 minutes.
- **Mechanical stimulation at mild pain intensity** (ACTIVE_COMPARATOR) — Mechanical compression is applied with the thumb to the upper trapezius muscle on the non-dominant side at the midpoint between the acromion and C7. The intensity of this will be regulated by the pain it causes the patient, trying to ensure that it is at all times approximately 2/10 on the numerical pain rating scale (NPRS) with 0 being "no pain at all" and 10 being "the worst pain imaginable". The stimulation will be carried out for 2 minutes.
- **Painless mechanical stimulation** (ACTIVE_COMPARATOR) — Mechanical compression is applied with the thumb to the upper trapezius muscle on the non-dominant side at the midpoint between the acromion and C7. The intensity of this will be regulated by the pain it causes the patient, trying to ensure that it is at all times approximately 0/10 on the numerical pain rating scale (NPRS) with 0 being "no pain at all" and 10 being "the worst pain imaginable". The stimulation will be carried out for 2 minutes.

## Interventions

- **Mechanical Conditioning stimulus** (OTHER) — Mechanical stimulus on the upper trapezius of the non-dominant side.

## Primary Outcomes

- **Change from Baseline in Tibialis Anterior Pressure Pain Threshold (PPT) to immediate post-conditioning stimulus** _(time frame: At baseline and immediately after the conditioning stimulus)_ — PPTs will be assessed on the dominant side over the tibialis anterior muscle using a digital algometer (Wagner instruments, Greenwich, CT, USA). Participants will be instructed to say "stop" when the pressure sensation becomes painful.The average of 3 assessments on the tibialis anterior of the dominant side will be performed for analysis. The algometer pressure for assessment will be gradually increased at a rate of 1kg/second. Data will be collected in kg/cm2.

## Locations (1)

- Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.universidad rey juan carlos|alcorcón|madrid|spain` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05730166.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05730166*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*