---
title: Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)
nct_id: NCT05775263
overall_status: UNKNOWN
sponsor: Papworth Hospital NHS Foundation Trust
study_type: OBSERVATIONAL
primary_condition: Cerebral Blood Flow
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05775263.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05775263"
ct_last_update_post_date: 2023-11-28
last_seen_at: "2026-05-12T06:38:12.513Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)

**NCT ID:** [NCT05775263](https://clinicaltrials.gov/study/NCT05775263)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 10
- **Lead Sponsor:** Papworth Hospital NHS Foundation Trust
- **Collaborators:** Cambridge University Hospitals NHS Foundation Trust
- **Conditions:** Cerebral Blood Flow
- **Start Date:** 2024-06-01
- **Completion Date:** 2025-06-01
- **CT.gov Last Update:** 2023-11-28

## Brief Summary

This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP. This will be assessed through the use of two modalities: CT angiogram of the brain and continuous Hb02 readings. The study group hypothesise that such assessment methods will provide evidence to indicate that brain blood flow is not present during NRP and promote trust in the use of such novel techniques in routine practice.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* DCD donors in Cambridge University Hospital
* Planned A-NRP
* Consent for study has been obtained
* Those who meet the appropriate criteria for DCD donation following WOLST
* ≥ 18 years of age
* ≤ 75 years of age

Exclusion Criteria:

* DBD organ donors
* DCD organ donations outside of Cambridge University Hospital
* DCD donors without planned A-NRP
* DCD donors whose family have withheld consent for brain blood flow investigations.
* Patients who do not meet the appropriate criteria for DCD donation following WOLST
* Patients with injuries that will physically prevent use of the necessary assessment methods
```

## Arms

- **A-NRP**
- **TA-NRP**

## Interventions

- **CT angiogram** (PROCEDURE) — CT angiography of the brain 30 minutes from establishment of NRP

## Primary Outcomes

- **CT angiogram** _(time frame: 30 minutes from establishment of NRP)_ — Brain blood flow

## Secondary Outcomes

- **Cerebral oximetry** _(time frame: Prior to withdrawal of life sustaining treatment to 30 minutes after establishment of NRP)_

## Recent Field Changes (last 30 days)

- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05775263*  
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