---
title: Efficacy of Virtual Reality Based Exercise Regimes on Kinesiophobia, Pain and Functional Disability in Patients With Knee Osteoarthritis
nct_id: NCT05777421
overall_status: UNKNOWN
phase: NA
sponsor: Foundation University Islamabad
study_type: INTERVENTIONAL
primary_condition: Knee Osteoarthristis
countries: Pakistan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05777421.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05777421"
ct_last_update_post_date: 2023-03-21
last_seen_at: "2026-05-12T06:39:28.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Efficacy of Virtual Reality Based Exercise Regimes on Kinesiophobia, Pain and Functional Disability in Patients With Knee Osteoarthritis

**NCT ID:** [NCT05777421](https://clinicaltrials.gov/study/NCT05777421)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 24
- **Lead Sponsor:** Foundation University Islamabad
- **Conditions:** Knee Osteoarthristis
- **Start Date:** 2023-01-01
- **Completion Date:** 2023-07-01
- **CT.gov Last Update:** 2023-03-21

## Brief Summary

Knee Osteoarthritis is one of the most prevalent degenerative conditions in Pakistan. Although a variety of Physical therapy treatments have been proven to be beneficial in patients with early stages of knee Osteoarthritis. However, a few secondary impairments like Kinesiophobia which is the fear of movement have been unaddressed. Usually after conventional physical therapy, patients find immediate or short-term relief and that leads to cessation of follow up sessions. In situations like these, kinesiophobia is the greatest threat to mobility and can eventually effect quality of life by decreasing functional disability.

## Eligibility

- **Minimum age:** 45 Years
- **Maximum age:** 65 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients with unilateral knee OA involving mediolateral compartment
* Knee OA grade 2
* Aged 40-65 years
* Both Male and Female
* NPRS value greater than

Exclusion Criteria:

* Patients with history of
* History of systemic disorder (e.g., rheumatoid arthritis, ankylosing spondylitis).
* History of malignancy.
* History of trauma.
* Previous knee surgery.
* Congenital musculoskeletal deformity (e.g., scoliosis, kyphosis).
* Patients with history of fracture
* Patients with history of Chondropatella Malacia
```

## Arms

- **Conventional Physical Therapy Regime for Knee Osteoarthrithis** (ACTIVE_COMPARATOR) — Pt will receive conventional therapy targeting stretching and stretching of knee musculature in combination with electrotherapy for pain modulation.

Frequency : 2-3 times for a duration of 6 weeks Pt will be guided home plan based exercises.
- **Virtual reality Based Therapeutic Exercise Regimes** (EXPERIMENTAL) — VR-based therapeutic exercise regimes utilizing Xbox, that focus on different activities like Partial squatting, lunges, side lunge, calf raises, and hamstring curls.

Gaming exercises begin will an easy warm up round and get challenging with different rounds of each game as the patient progresses to week 6.

Frequency: 2-3 times for a duration for 6 weeks Pt will be guided home plan based exercises

## Interventions

- **Conventional Physical Therapy for Knee Osteoarthriths** (PROCEDURE) — Participants of Group A will receive the conventional physical therapy for Knee Osteoarthistis for a duration of 6 weeks atleast 2 times a week
- **Virtual Reality-Based Therapeutic Exercise regimes** (PROCEDURE) — * Participants of Group B will receive Virtual Reality Based therapeutic exercises on the Xbox. The difficulty level of the games will progess each week. The duration of training will also also progress at treatment week progresses.
* Frequency: 2-3 times a week for 6 weeks. Minimum 12 sessions in total.

## Primary Outcomes

- **Kinesiophobia** _(time frame: 6 weeks)_ — Kinesiophobia will be measured using the Tampa Scale of Kinesiophobia
- **Pain intensity** _(time frame: 6 weeks)_ — Will be Measured using the Numeric Pain rating scale
- **Functional Disability** _(time frame: 6 weeks)_ — Will be measured using WOMAC Osteoarthritis Index

## Locations (1)

- Foundation University College of Physical Therapy, Rawalpindi, Punjab Province, Pakistan

## Recent Field Changes (last 30 days)

- `eligibility.sex` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.foundation university college of physical therapy|rawalpindi|punjab province|pakistan` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05777421.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05777421*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*