---
title: McGrath Videolaryngoscopy and Direct Laryngoscopy Rapid Sequence Intubation
nct_id: NCT05850052
overall_status: COMPLETED
phase: NA
sponsor: The Cleveland Clinic
study_type: INTERVENTIONAL
primary_condition: Surgery
countries: Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05850052.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05850052"
ct_last_update_post_date: 2025-02-03
last_seen_at: "2026-05-12T06:43:02.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# McGrath Videolaryngoscopy and Direct Laryngoscopy Rapid Sequence Intubation

**Official Title:** Comparison of Comparison of McGrath Videolaryngoscopy and Direct Laryngoscopy for Rapid Sequence Intubation: an International, Multicenter Randomized Trial

**NCT ID:** [NCT05850052](https://clinicaltrials.gov/study/NCT05850052)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 400
- **Lead Sponsor:** The Cleveland Clinic
- **Conditions:** Surgery
- **Start Date:** 2023-05-07
- **Completion Date:** 2024-08-05
- **CT.gov Last Update:** 2025-02-03

## Brief Summary

The study seeks to compare the efficacy of conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for rapid sequence endotracheal intubation.

## Detailed Description

The study aims to conduct a multicenter international trial to enroll a maximum of 800 consenting adults who fall under the American Society of Anesthesiologists (ASA) physical status 1-3 category and require elective non-cardiac surgery necessitating endotracheal intubation with rapid sequence induction for general anesthesia. The study seeks to compare the efficacy of conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for rapid sequence endotracheal intubation.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 99 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Elective surgery requiring oral endotracheal intubation for general anesthesia;
* Anticipated extubation in the operating room;
* American Society of Anesthesiologists (ASA) physical status 2-3;
* Age between 18 and 99 years;
* Body Mass index ≥ 40 kg/m2.

Exclusion Criteria:

* Refusal of participation by attending anesthesiologist;
* Indicated rapid sequence induction for any reason including, but not limited to high risk of aspiration
* Indicated fiberoptic awake intubation.
```

## Arms

- **McGrath Videolaryngoscope for rapid endotracheal intubation** (EXPERIMENTAL) — The researchers will use the McGrath videolaryngoscope for rapid sequence endotracheal intubation.
- **Efficacy of conventional direct laryngoscopy** (OTHER) — The researchers seek to compare the efficacy of conventional direct laryngoscopy using a Macintosh blade.

## Interventions

- **McGrath videolaryngoscope for rapid sequence endotracheal intubation** (DEVICE) — Visualize a patient's airway to aid placement of tracheal tube with ease.
- **Conventional direct laryngoscopy using a Macintosh blade** (DEVICE) — Examine a patient's airway to aid placement of tracheal tube with ease.

## Primary Outcomes

- **Visualization of the Vocal Cords** _(time frame: From the start time of intubation to time of the end of surgery, up to 12 hours.)_ — The visualization of the vocal cords, defined using the modified Cormack and Lehane classification:

Grade I: Full view of the glottis (vocal cords are completely visible). Grade IIa: Partial view of the glottis (only the posterior portion of the glottis is visible).

Grade IIb: Only the arytenoids or the posterior extremity of the vocal cords are visible (the anterior commissure is not seen).

Grade III: Only the epiglottis is visible (the glottis is not visible). Grade IV: Neither the epiglottis nor the glottis is visible (only the soft palate is seen).

## Secondary Outcomes

- **Number of Participants With 1, 2, 3, and 4 Intubation Attempts** _(time frame: From the start time of intubation to time of the end of surgery, up to 12 hours.)_
- **Intubation Failure.** _(time frame: From the start time of intubation to time of the end of surgery, up to 12 hours.)_

## Locations (2)

- The University of Health Science, Bakirkoy Dr. Sadi Konuk Education, and Research Hospital,, Istanbul, Turkey (Türkiye)
- The University of Health Science, Konya City Hospital, Konya, Turkey (Türkiye)

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.the university of health science, bakirkoy dr. sadi konuk education, and research hospital,|istanbul||turkey (türkiye)` — added _(2026-05-12)_
- `locations.the university of health science, konya city hospital|konya||turkey (türkiye)` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05850052.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05850052*  
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