---
title: Articulatory Adaptation Following Oral Cancer Treatment
nct_id: NCT05876247
overall_status: UNKNOWN
sponsor: University Medical Center Groningen
study_type: OBSERVATIONAL
primary_condition: Oral Cavity Squamous Cell Carcinoma
countries: Netherlands
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05876247.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05876247"
ct_last_update_post_date: 2023-05-30
last_seen_at: "2026-05-12T07:30:31.013Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Articulatory Adaptation Following Oral Cancer Treatment

**Official Title:** Speech Flexibility in Adulthood Following Oral Cancer Treatment: Acoustic and Kinematic Explorations

**NCT ID:** [NCT05876247](https://clinicaltrials.gov/study/NCT05876247)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 50
- **Lead Sponsor:** University Medical Center Groningen
- **Conditions:** Oral Cavity Squamous Cell Carcinoma, Speech Disorders
- **Start Date:** 2022-11-10
- **Completion Date:** 2025-08
- **CT.gov Last Update:** 2023-05-30

## Brief Summary

The goal of this longitudinal study is to learn more about the articulatory consequences of surgical oral cancer treatment. The main aims are to study the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or tactile information can predict the success of speech compensatory strategies.

Participants will perform multiple speech tasks while motion tracking sensors track the articulatory gestures.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

1. Diagnosed with T1 or T2 tumor in the oral cavity
2. At least 18 years old and able to provide informed consent
3. Native speaker of Dutch
4. Has nog been treated for oral cancer before

Exclusion Criteria:

1a. Recurrence of disease (for patients)

1b. Treated for oral cancer (for healthy controls) 2. Speech problems (e.g., stuttering) 3. Problems with sight or hearing that impede reading or understanding instructions. When glasses or a hearing aid resolve these problems, then participants are not excluded.

4\. Neurological or psychological disorders (e.g., stroke) 5. Non-removable metal in, on or around the head (piercings, braces, pacemaker, electrodes) 6. Self-reported signs of depression
```

## Arms

- **Individuals treated for oral cancer** — Dutch native speakers (18+) who will undergo surgical treatment for a T1 or T2 tumour on the tongue.
- **Control speakers** — Dutch native speakers (18+) without self-reported speech problems.

## Interventions

- **Electromagnetic Articulography** (OTHER) — Motion tracking sensors will track articulatory movements of the tongue, jaw and lips

## Primary Outcomes

- **Articulatory gestures** _(time frame: 2022-2025)_ — Articulatory movements in three dimensions of the tongue, lips and jaw as measured by the NDI Vox Electromagnetic Articulograph. Measures include: articulator speed (mm/s), total displacement (mm), coordinates (x,y,z) during specific gestures.
- **Acoustic outcomes** _(time frame: 2022-2025)_ — Speech acoustics will be measured in Praat and include the first and second formants of vowels (in Hz), global movement size in terms of acoustic working space (Hz-squared), and the centre of gravity of sibilants (in Hz)

## Locations (2)

- Faculty of Arts, University of Groningen, Groningen, Netherlands — _RECRUITING_
- University Medical Centre Groningen, Groningen, Netherlands — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.faculty of arts, university of groningen|groningen||netherlands` — added _(2026-05-12)_
- `locations.university medical centre groningen|groningen||netherlands` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05876247.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05876247*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*