---
title: "Exercise-snacks at Work: Impact on Cardiometabolic Parameters"
nct_id: NCT05942144
overall_status: TERMINATED
phase: NA
sponsor: University of Avignon
study_type: INTERVENTIONAL
primary_condition: Sedentary Time
countries: France
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05942144.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05942144"
ct_last_update_post_date: 2025-04-20
last_seen_at: "2026-05-12T06:35:06.585Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Exercise-snacks at Work: Impact on Cardiometabolic Parameters

**Official Title:** Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers

**NCT ID:** [NCT05942144](https://clinicaltrials.gov/study/NCT05942144)

## Key Facts

- **Status:** TERMINATED
- **Why Stopped:** Post hoc power analysis results on the primary hypothesis during the preliminary analyses
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 23
- **Lead Sponsor:** University of Avignon
- **Conditions:** Sedentary Time, Overweight and Obesity, Work-Related Condition
- **Start Date:** 2023-05-16
- **Completion Date:** 2024-07-20
- **CT.gov Last Update:** 2025-04-20

## Brief Summary

The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health

## Detailed Description

Backgrounds: Very short (\< 1 minute) and intense exercises, entitled "exercise-snacks", have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic "exercise-snacks" program applicable in the professional environment to sedentary, overweight people.

Aims of this project is therefore to measure the effects of an "exercise-snacks" type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.

## Eligibility

- **Minimum age:** 30 Years
- **Maximum age:** 60 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* administrative staff,
* age between 30 and 60,
* body mass index ≥25kg/m²,
* sedentary time ≥7h/day,
* minimum 3 working days on site,
* no known cardiovascular or metabolic pathology, social security affiliation or benefit,
* ability and willingness to give free, written and informed consent.

Exclusion Criteria:

* pregnant or breast-feeding women,
* anti-hypertensive treatment, beta-blockers and anti-diabetics,
* known contraindications to physical activity (articular, cardiac or other),
* exercise-induced asthma,
* lack of motivation of subjects posing problems of compliance and adherence to the exercise program,
* participation in a study in the preceding 3 months, ongoing participation in a clinical trial.
```

## Arms

- **Exercise-snacks group** (EXPERIMENTAL) — They will perform a "exercise-snacks" program and receive information about physical activity
- **Control group** (NO_INTERVENTION) — They will maintain their usual lifestyle until the end of the study

## Interventions

- **Exercise-snacks program** (OTHER) — Subjects in the exercise-snacks group will perform 4 "exercise-snacks" sessions per working day for 4 weeks. These sessions will consist of 80 one-to-one walks to be completed as quickly as possible. They will also receive information about their attitudes to physical activity.

## Primary Outcomes

- **Changes in aerobic fitness** _(time frame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program)_ — Aerobic fitness will be assessed via the Chester step test's prediction of VO2max

## Secondary Outcomes

- **Adherence of staff in the experimental group by analyzing accelerometric data.** _(time frame: during the 4-weeks program)_
- **Intensity of exercise-snacks** _(time frame: during the 4-weeks program)_
- **Changes in flow mediated dilation of superficial femoral artery** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in peak shear rate of superficial femoral artery** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in nitrate mediated dilation of superficial femoral artery** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in superficial femoral artery compliance** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in carotid intima-thickness** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in carotid compliance** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in carotid-femoral pulse wave velocity** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in post-occlusive skin perfusion** _(time frame: at inclusion, at the end of the 4-weeks program)_
- **Changes in blood pressure** _(time frame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program)_
- **Changes in mean amplitude of glycemic excursions** _(time frame: one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program)_
- **Changes in heart rate** _(time frame: between the beginning and end of the 4-week exercise program and 4 weeks after the program.)_
- **Changes in level of habitual physical activity** _(time frame: between the start and end of the 4-week exercise program and 4 weeks after the program)_
- **Changes in fat mass** _(time frame: between the start and end of the 4-week exercise program and 4 weeks after the program)_
- **Changes in lean mass** _(time frame: between the start and end of the 4-week exercise program and 4 weeks after the program)_
- **Change in physical activity behaviour at work of staff** _(time frame: between the start and end of the 4-week exercise program.)_
- **Changes in rating of perceived exertion** _(time frame: between the start and end of the 4-week exercise program and 4 weeks after the program)_

## Locations (1)

- Avignon University, Avignon, France

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.whyStopped` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.avignon university|avignon||france` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05942144.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05942144*  
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