---
title: Evaluation of the POSOS Device for Iatrogenesis Detection in Clinical History? A Vignettes Study
nct_id: NCT05952193
overall_status: UNKNOWN
sponsor: Centre Hospitalier Universitaire, Amiens
study_type: OBSERVATIONAL
primary_condition: Iatrogenesis
countries: France
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05952193.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05952193"
ct_last_update_post_date: 2023-07-19
last_seen_at: "2026-05-12T07:26:32.313Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Evaluation of the POSOS Device for Iatrogenesis Detection in Clinical History? A Vignettes Study

**NCT ID:** [NCT05952193](https://clinicaltrials.gov/study/NCT05952193)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 128
- **Lead Sponsor:** Centre Hospitalier Universitaire, Amiens
- **Collaborators:** Centre Hospitalier de Bourg en Bresse, Saint Antoine University Hospital, CHU de Rouen - Accueil, CHU de Créteil, Médipôle Lyon-Villeurbanne, Centre Hospitalier Universitaire de Nice, University Hospital, Montpellier, University Hospital, Lille, Centre Hospitalier de Niort, Centre Hospitalier Régional Metz-Thionville, University Hospital, Grenoble, CHU de Reims
- **Conditions:** Iatrogenesis, Clinical Vignettes, Diagnostic Performance Study, Medical Information Search, Artificial Intelligence
- **Start Date:** 2023-06-21
- **Completion Date:** 2024-07
- **CT.gov Last Update:** 2023-07-19

## Brief Summary

This study is a multicenter evaluation of diagnostic performance using simulated clinical vignettes. It aims to test the effectiveness of the POSOS app in detecting drug-induced iatrogenesis in urgent medical situations, an issue of public health importance. Participating physicians, who are randomly assigned to either use or not use POSOS, are categorized based on their years of experience. Vignettes, including a mixture of complex, simple, and non-iatrogenesis cases, are assigned to these doctors. During the simulation, physicians respond to their respective vignettes on the YgheniVi platform, with responses recorded at two intervals (5 min and 15 min). The supervising physicians subsequently fill out an e-CRF, providing further data on the time spent, the number of medical research applications used, and the overall user experience of POSOS. A doctor/pharmacist pair then corrects the answers to the vignettes.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Not applicable as the study population is made up of clinical vignettes, there is no inclusion of patients.
* The physicians included are emergency physicians, selected by convenience so as to have as many physicians (seniority of practice 3 years after thesis) as (seniority of practice less).

Exclusion Criteria:

* Not applicable.
* Simulations with technical faults will be excluded: (absence of the test doctor, internet access not working, PC malfunction, serious disruptions during the simulation).
```

## Arms

- **seniority ≥3 years + POSOS**
- **seniority ≥3 years without POSOS**
- **seniority <3 years with POSOS**
- **seniority <3 years without POSOS**

## Primary Outcomes

- **the proportion of overall correct responses in each groups** _(time frame: 5 minutes)_

## Locations (1)

- CHU Amiens, Amiens, France — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.chu amiens|amiens||france` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05952193*  
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