--- title: A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy nct_id: NCT05988073 overall_status: ACTIVE_NOT_RECRUITING sponsor: argenx study_type: OBSERVATIONAL primary_condition: Multifocal Motor Neuropathy countries: United States, Australia, Austria, Belgium, Bulgaria, Canada, China, Czechia, Denmark, France, Germany, Italy, Japan, Latvia, Poland, Romania, Serbia, Spain, Sweden, United Kingdom canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05988073.md" clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05988073" ct_last_update_post_date: 2026-03-16 last_seen_at: "2026-05-12T06:19:10.285Z" source: ClinicalTrials.gov (mirrored, no enrichment) --- # A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy **Official Title:** A Multicenter Prospective Longitudinal Study of Clinical Outcomes, Disease Course, Health-Related Quality of Life, and Health Care Resource Utilization in Adult Patients With Multifocal Motor Neuropathy **NCT ID:** [NCT05988073](https://clinicaltrials.gov/study/NCT05988073) ## Key Facts - **Status:** ACTIVE_NOT_RECRUITING - **Study Type:** OBSERVATIONAL - **Target Enrollment:** 413 - **Lead Sponsor:** argenx - **Conditions:** Multifocal Motor Neuropathy - **Start Date:** 2023-11-29 - **Completion Date:** 2028-12-31 - **CT.gov Last Update:** 2026-03-16 ## Brief Summary This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources. Participants will follow their regular visit schedule with their treating physician, except for an optional second visit occurring 7 to 14 days after the start of the study to collect biomarker data. No IMP will be administered. ## Eligibility - **Minimum age:** 18 Years - **Sex:** ALL - **Healthy Volunteers:** No ``` Inclusion Criteria: * Is at least the local legal age of consent for clinical studies when signing the ICF * Is capable of providing signed informed consent and complying with protocol requirements * Has an existing or new diagnosis of MMN made by a neuromuscular specialist or neurologist Exclusion Criteria: * Is currently participating in any clinical study with an IMP * Has other medical conditions that could affect the assessment of MMN ``` ## Primary Outcomes - **To characterize MMN patient profiles for participants** _(time frame: up to 61 months)_ - **To assess the MMN disease management and disease course** _(time frame: up to 61 months)_ - **To assess outcome measures specific to MMN disease and their evolution over time** _(time frame: up to 61 months)_ - **To estimate the burden of MMN on participants' quality of life** _(time frame: up to 61 months)_ - **To estimate the economic burden for participants with MMN** _(time frame: up to 61 months)_ - **To collect data on relevant disease biomarkers** _(time frame: up to 61 months)_ ## Locations (113) - Neuromuscular Clinical and Research Center, Phoenix, Arizona, United States - HonorHealth Neurology - Bob Bove Neuroscience Institute, Scottsdale, Arizona, United States - UCI Health - ALS and Neuromuscular Center, Orange, California, United States - Stanford Medicine Health Care - Stanford Neuroscience Health Center, Palo Alto, California, United States - The Neurology Group, Pomona, California, United States - Eisenhower Health - Rancho Mirage Medical Center, Rancho Mirage, California, United States - UC Davis Health - Lawrence J. Ellison Ambulatory Care Center, Sacramento, California, United States - UCSF Health - UCSF Medical Center, San Francisco, California, United States - University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States - YaleNewHavenHealth - Yale New Haven Hospital, New Haven, Connecticut, United States - Medsol Clinical Research Center Inc, Port Charlotte, Florida, United States - D&H National Research Centers - Tamarac Research Center, Tamarac, Florida, United States - Hospital Sisters Health System (HSHS) - St Elizabeth's Hospital, O'Fallon, Illinois, United States - The University of Kansas Health System - Landon Center on Aging, Kansas City, Kansas, United States - MedStar Georgetown University Hospital, Chevy Chase, Maryland, United States - Rutgers University - Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States - Columbia University Irving Medical Center - Neurological Institute of New York, New York, New York, United States - University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States - Ohio State University Wexner Medical Center - Ohio State Martha Morehouse Outpatient Care, Columbus, Ohio, United States - Oregon Health and Science University (OHSU) Hospital - Marquam Hill Campus, Portland, Oregon, United States - Penn Medicine - Penn Medicine University City, Philadelphia, Pennsylvania, United States - Penn Medicine - Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania, United States - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States - Northwest Houston Neurology - Cypress, Cypress, Texas, United States - Royal Melbourne Hospital, Parkville, Australia - Gold Coast University Hospital, Southport, Australia - Princess Alexandra Hospital, Woolloongabba, Australia - Allgemeines Krankenhaus der Stadt Wien (AKH Wien), Vienna, Austria - Hopital Erasme, Brussels, Belgium - Universitair Ziekenhuis Antwerpen, Edegem, Belgium - Universitair Ziekenhuis Gent, Ghent, Belgium - Universitair Ziekenhuis Brussel, Jette, Belgium - Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Belgium - L'hopital de la Citadelle - Site Citadelle, Liège, Belgium - Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Belgium - Multiprofile Hospital for Active Treatment - Uni Hospital OOD, Panagyurishte, Bulgaria - Medical Center Medconsult Pleven OOD, Pleven, Bulgaria - Military Medical Academy - Military Hospital for Active Treatment Pleven, Pleven, Bulgaria - University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov, Sofia, Bulgaria - London Health Sciences Centre - University Hospital, London, Canada - Centre Hospitalier de l'Universite de Montreal, Montreal, Canada - McGill University Health Centre - The Neuro (Montreal Neurological Institute-Hospital), Montreal, Canada - CHU de Quebec - Hopital de L'enfant Jesus, Québec, Canada - University of Saskatchewan - University of Saskatchewan College of Medicine, Saskatoon, Canada - Xiangya Hospital of Central South University, Changsha, China - The First Affiliated Hospital of Nanchang University, Nanchang, China - Huashan Hospital of Fudan University, Shanghai, China - Fakultni nemocnice Brno - Areal Bohunice, Brno, Czechia - Fakultni nemocnice Hradec Kralove, Hradec Králové, Czechia - Aarhus Universitetshospital, Aarhus, Denmark - Rigshospitalet - Blegdamsvej, Copenhagen, Denmark - CHU Angers, Angers, France - CHU de Bordeaux - Hôpital Pellegrin, Bordeaux, France - CHU Brest - Hopital La Cavale Blanche, Brest, France - Hospices Civils de Lyon (HCL) - Hopital Pierre Wertheimer, Bron, France - Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Bicetre, Le Kremlin-Bicêtre, France - CHU Lille - Hopital Salengro, Lille, France - CHU de Limoges - CHU Dupuytren 1, Limoges, France - AP-HM - CHU Timone, Marseille, France - CHU de Nantes - Hotel Dieu, Nantes, France - CHU de Nice - Hopital Pasteur, Nice, France - Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Pitie-Salpetriere, Paris, France - Universitatsklinikum Essen, Essen, Germany - Universitatsklinikum Giessen und Marburg - Campus Giessen, Giessen, Germany - Medizinische Hochschule Hannover, Hanover, Germany - St. Josefs- Krankenhaus Potsdam- Sanssouci, Potsdam, Germany - Universitatsklinikum Wurzburg, Würzburg, Germany - Azienda Ospedaliero Universitaria Careggi, Florence, Italy - Fondazione Serena Onlus - NeMO Brescia, Gussago, Italy - Azienda Ospedaliera Universitaria Gaetano Martino, Messina, Italy - Universita degli Studi del Piemonte Orientale Amedeo Avogadro - Scuola di Medicina, Novara, Italy - Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, Italy - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, Italy - Istituto Neurologico Nazionale a Carattere Scientifico IRCCS, Pavia, Italy - Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara, Pisa, Italy - Azienda Ospedaliero Universitaria Sant'Andrea, Roma, Italy - Fondazione PTV Policlinico Tor Vergata, Roma, Italy - Teikyo University Hospital, Itabashi-ku, Japan - National Center of Neurology and Psychiatry, Kodaira-shi, Japan - Dokkyo Medical University Hospital, Mibu, Japan - Riga East Clinical University Hospital, Riga, Latvia - Pauls Stradins Clinical University Hospital, Riga, Latvia - Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Bydgoszcz, Bydgoszcz, Poland - Wielospecjalistyczna Poradnia Lekarska Synapsis, Katowice, Poland - Specjalistyczne Gabinety Sp. z o.o., Krakow, Poland - Michalski i Partnerzy Lekarze Spolka Partnerska, Krakow, Poland - SP ZOZ Szpital Uniwersytecki w Krakowie, Krakow, Poland - CLINIREM Sp z o.o., Lublin, Poland - Rejdak Konrad Indywidualna Praktyka Lekarska, Lublin, Poland - Centrum Medyczne Hope Clinic, Lublin, Poland - ETG Network - ETG Neuroscience, Warsaw, Poland - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei, Constanța, Romania - Univerzitetski klinicki centar Srbije, Belgrade, Serbia - Univerzitetski klinicki centar Kragujevac, Kragujevac, Serbia - Hospital General Universitario Dr. Balmis, Alicante, Spain - Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, Spain - Hospital de la Santa Creu i Sant Pau, Barcelona, Spain - Hospital Universitario de Basurto, Bilbao, Spain - Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain - Hospital Universitario Central de Asturias, Oviedo, Spain - Hospital Universitario de Navarra, Pamplona, Spain - Hospital Universitario de Donostia, San Sebastián, Spain - Sahlgrenska Universitetssjukhuset - MS - mottagning Sahlgrenska, Gothenburg, Sweden - Karolinska Universitetssjukhuset - Huddinge, Huddinge, Sweden - North Bristol NHS Trust - Southmead Hospital Bristol, Bristol, United Kingdom - Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital, Fulwood, United Kingdom - NHS Great Glasgow and Clyde - Queen Elizabeth University Hospital, Glasgow, United Kingdom - Nottingham University Hospitals NHS Trust - Queen's Medical Centre, Nottingham, United Kingdom - Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital, Oxford, United Kingdom - Northern Care Allicance NHS Foundation Trust - Salford Royal, Salford, United Kingdom - Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire Hospital, Sheffield, United Kingdom - Somerset NHS Foundation Trust - Musgrove Park Hospital, Taunton, United Kingdom - Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital, Truro, United Kingdom ## Recent Field Changes (last 30 days) - `status.overallStatus` — added _(2026-05-12)_ - `status.primaryCompletionDate` — added _(2026-05-12)_ - `status.completionDate` — added _(2026-05-12)_ - `status.lastUpdatePostDate` — added _(2026-05-12)_ - `design.enrollmentCount` — added _(2026-05-12)_ - `eligibility.criteria` — added _(2026-05-12)_ - `eligibility.minAge` — added _(2026-05-12)_ - `eligibility.sex` — added _(2026-05-12)_ - `outcomes.primary` — added _(2026-05-12)_ - `sponsor.lead` — added _(2026-05-12)_ - `results.hasResults` — added _(2026-05-12)_ - `locations.neuromuscular clinical and research center|phoenix|arizona|united states` — added _(2026-05-12)_ - `locations.honorhealth neurology - bob bove neuroscience institute|scottsdale|arizona|united states` — added _(2026-05-12)_ - `locations.uci health - als and neuromuscular center|orange|california|united states` — added _(2026-05-12)_ - `locations.stanford medicine health care - stanford neuroscience health center|palo alto|california|united states` — added _(2026-05-12)_ - `locations.the neurology group|pomona|california|united states` — added _(2026-05-12)_ - `locations.eisenhower health - rancho mirage medical center|rancho mirage|california|united states` — added _(2026-05-12)_ - `locations.uc davis health - lawrence j. ellison ambulatory care center|sacramento|california|united states` — added _(2026-05-12)_ - `locations.ucsf health - ucsf medical center|san francisco|california|united states` — added _(2026-05-12)_ - `locations.university of colorado - anschutz medical campus|aurora|colorado|united states` — added _(2026-05-12)_ - `locations.yalenewhavenhealth - yale new haven hospital|new haven|connecticut|united states` — added _(2026-05-12)_ - `locations.medsol clinical research center inc|port charlotte|florida|united states` — added _(2026-05-12)_ - `locations.d&h national research centers - tamarac research center|tamarac|florida|united states` — added _(2026-05-12)_ - `locations.hospital sisters health system (hshs) - st elizabeth's hospital|o'fallon|illinois|united states` — added _(2026-05-12)_ - `locations.the university of kansas health system - landon center on aging|kansas city|kansas|united states` — added _(2026-05-12)_ - `locations.medstar georgetown university hospital|chevy chase|maryland|united states` — added _(2026-05-12)_ - `locations.rutgers university - robert wood johnson medical school|new brunswick|new jersey|united states` — added _(2026-05-12)_ - `locations.columbia university irving medical center - neurological institute of new york|new york|new york|united states` — added _(2026-05-12)_ - `locations.university of north carolina - chapel hill|chapel hill|north carolina|united states` — added _(2026-05-12)_ - `locations.universitair ziekenhuis antwerpen|edegem||belgium` — added _(2026-05-12)_ - `locations.ohio state university wexner medical center - ohio state martha morehouse outpatient care|columbus|ohio|united states` — added _(2026-05-12)_ - `locations.oregon health and science university (ohsu) hospital - marquam hill campus|portland|oregon|united states` — added _(2026-05-12)_ - `locations.penn medicine - penn medicine university city|philadelphia|pennsylvania|united states` — added _(2026-05-12)_ - `locations.penn medicine - perelman center for advanced medicine|philadelphia|pennsylvania|united states` — added _(2026-05-12)_ - `locations.university of pittsburgh medical center|pittsburgh|pennsylvania|united states` — added _(2026-05-12)_ - `locations.northwest houston neurology - cypress|cypress|texas|united states` — added _(2026-05-12)_ - `locations.royal melbourne hospital|parkville||australia` — added _(2026-05-12)_ - `locations.gold coast university hospital|southport||australia` — added _(2026-05-12)_ - `locations.princess alexandra hospital|woolloongabba||australia` — added _(2026-05-12)_ - `locations.allgemeines krankenhaus der stadt wien (akh wien)|vienna||austria` — added _(2026-05-12)_ - `locations.hopital erasme|brussels||belgium` — added _(2026-05-12)_ - `locations.universitair ziekenhuis gent|ghent||belgium` — added _(2026-05-12)_ - `locations.universitair ziekenhuis brussel|jette||belgium` — added _(2026-05-12)_ - `locations.universitair ziekenhuis leuven - campus gasthuisberg|leuven||belgium` — added _(2026-05-12)_ - `locations.l'hopital de la citadelle - site citadelle|liège||belgium` — added _(2026-05-12)_ - `locations.cliniques universitaires saint-luc|woluwe-saint-lambert||belgium` — added _(2026-05-12)_ - `locations.multiprofile hospital for active treatment - uni hospital ood|panagyurishte||bulgaria` — added _(2026-05-12)_ - `locations.medical center medconsult pleven ood|pleven||bulgaria` — added _(2026-05-12)_ - `locations.military medical academy - military hospital for active treatment pleven|pleven||bulgaria` — added _(2026-05-12)_ - `locations.university multiprofile hospital for active treatment and emergency medicine n. i. pirogov|sofia||bulgaria` — added _(2026-05-12)_ --- *Canonical: https://parkinsonspathways.com/agent/trials/NCT05988073.md* *Source data (authoritative): https://clinicaltrials.gov/study/NCT05988073* *This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*