---
title: Pain Management After Adductor Canal Block for Total Knee Arthroplasty
nct_id: NCT06086483
overall_status: COMPLETED
phase: PHASE4
sponsor: Poznan University of Medical Sciences
study_type: INTERVENTIONAL
primary_condition: Knee Osteoarthritis
countries: Poland
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06086483.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06086483"
ct_last_update_post_date: 2023-10-17
last_seen_at: "2026-05-12T06:20:07.285Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Pain Management After Adductor Canal Block for Total Knee Arthroplasty

**Official Title:** Pain Management and Functional Recovery After Adductor Canal Block Combined With iPACK Block for Total Knee Arthroplasty. A Prospective, Randomized, Double-blinded Clinical Trial.

**NCT ID:** [NCT06086483](https://clinicaltrials.gov/study/NCT06086483)

## Key Facts

- **Status:** COMPLETED
- **Phase:** PHASE4
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 361
- **Lead Sponsor:** Poznan University of Medical Sciences
- **Conditions:** Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy, Knee Pain Chronic
- **Start Date:** 2020-06-18
- **Completion Date:** 2023-08-24
- **CT.gov Last Update:** 2023-10-17

## Brief Summary

This randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the iPACK block with Adductor Canal Block on postoperative pain, functional recovery and NLR and PLR levels.

## Detailed Description

The Interspace between the popliteal artery and capsule of the posterior knee, or iPACK block, together with the Adductor Canal block (ACB), has been described and shows promise in providing analgesia to the knee joint. However, the effect of these two blocks on postoperative pain levels, functional recovery, and stress response is uncertain. This study compares a preoperative iPACK and ACB block to Sham blocks before total knee arthroplasty under spinal anesthesia.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 100 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients \> 18 years old undergoing unilateral total knee arthroplasty

Exclusion Criteria:

* refusal to participate
* \< 18 yo
* Chronic opioid use
* localized infection
```

## Arms

- **iPACK block+ABC block** (ACTIVE_COMPARATOR) — Patients received a preoperative ultrasound-guided iPACK block with 20 mL of 0.25% ropivacaine and an Adductor Canal block with 20mL 0.25% ropivacaine.
- **Sham blocks** (ACTIVE_COMPARATOR) — Patients received a preoperative ultrasound-guided iPACK block with 20 mL of 0.9% normal saline and an Adductor Canal block with 20mL 0.9% normal saline.

## Interventions

- **Ropivacaine 0.2% Injectable Solution** (DRUG) — 20 mL 0.5% ropivacaine was injected into the PENG block

20 mL 0.5% ropivacaine was injected into the Adductor Canal block
- **0.9%sodium chloride** (DRUG) — 20 mL 0.9% sodium chloride was injected into the PENG block

20 mL 0.5% sodium chloride was injected into the Adductor Canal block

## Primary Outcomes

- **postoperative Numeric Pain Rating Scale** _(time frame: 24 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale et rest** _(time frame: 48 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale et rest** _(time frame: 72 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale et rest** _(time frame: 96 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale during active flexion** _(time frame: 48 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale during active flexion** _(time frame: 72 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
- **postoperative Numeric Pain Rating Scale during active flexion** _(time frame: 96 hours after surgery)_ — Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

## Secondary Outcomes

- **Postoperative opioid consumption** _(time frame: 96 hours after surgery)_
- **Neutrophil-to-lymphocyte ratio** _(time frame: 12 hours after surgery)_
- **Neutrophil-to-lymphocyte ratio** _(time frame: 24 hours after surgery)_
- **Platelet-to-lymphocyte ratio** _(time frame: 12 hours after surgery)_
- **Platelet-to-lymphocyte ratio** _(time frame: 24 hours after surgery)_
- **Time to first opioid administration** _(time frame: 96 hours postoperatively)_

## Locations (1)

- Poznan University of Medical Sciences, Poznan, Poznań, Poland

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.poznan university of medical sciences|poznan|poznań|poland` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT06086483*  
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