---
title: Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy
nct_id: NCT06091553
overall_status: UNKNOWN
phase: PHASE2
sponsor: Beni-Suef University
study_type: INTERVENTIONAL
primary_condition: Neuropathy in Cacer Patien
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06091553.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06091553"
ct_last_update_post_date: 2024-04-16
last_seen_at: "2026-05-12T06:25:26.685Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy

**Official Title:** Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy: A Randomized Controlled Trial

**NCT ID:** [NCT06091553](https://clinicaltrials.gov/study/NCT06091553)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** PHASE2
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 160
- **Lead Sponsor:** Beni-Suef University
- **Conditions:** Neuropathy in Cacer Patien
- **Start Date:** 2023-10-10
- **Completion Date:** 2024-12-31
- **CT.gov Last Update:** 2024-04-16

## Brief Summary

This study aimed to elucidate the relationship between the Efficacy and Safety of Comparison of the Efficacy and Safety Duloxetine augmented with gabapentin and amitriptyline augmented with Duloxetine vs duloxetine alone in chemotherapy -Induced Neuropathy in cancer patients.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* -Patients of any age must have histologically or cytologically confirmed cancer by the Laboratory of Pathology.
* Patients must sign an informed consent form (ICF) voluntarily and be able to understand and comply with the requirements of the study;
* Patients must be 18 to 75 years of age (including cut-offs) on the date of signing the informed consent form, regardless of gender;
* Patients must received treatment with a chemotherapy regimen .
* Patients must have ≥ grade 1 sensory chemotherapy-induced peripheral neuropathy (CIPN) with NRS ≥ 4/10 according to the NCI Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0 grading scale
* Eastern Cooperative Oncology Group performance status (ECOG PS): 0-2;
* Expected survival of ≥ 3 months
* There is no maximum number of prior medical therapies.

Exclusion Criteria:

* History of allergic reactions attributed to compounds of similar chemical or biologic composition to duloxetine, amitriptyline and gabapentin
* Pregnant women are excluded from this study.
* Life expectancy less than 6 months
* Inability or unwillingness to comply with research protocols.
* Patients with the presence of active brain or meningeal metastases.
* Patients with the presence of uncontrolled closed-angle glaucoma.
* Patients with the presence of neuropathy caused by any type of nerve compression as diabetes.
* The presence of mental illness, epilepsy, mania, suicidal depression, dementia or alcohol or drug abuse that may have an impact on compliance with trial requirements.
* The presence of comorbid cardiovascular disease, including but not limited to: (1) New York Heart Association (NYHA) criteria ≥ grade 2 heart failure; (2) severe/unstable angina pectoris; (3) myocardial infarction or cerebrovascular accident within 6 months prior to first dose; (4) atrial fibrillation and supraventricular or ventricular arrhythmias requiring treatment; (5) pre-existing symptomatic superior vena cava syndrome; (6) corrected QT interval (QTc) \> 450 ms (men); QTc \> 470 ms (women); (7) hypertensive disease not controlled by antihypertensive medication: systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg;
* Patients with other medical history or evidence of disease that has the potential to confound trial results are excluded from the study,
```

## Arms

- **Duloxetine alone (as monotherapy)** (ACTIVE_COMPARATOR) — Duloxetine alone (as monotherapy)
- **Duloxetine augmented with gabapentin (as combined therapy)** (ACTIVE_COMPARATOR) — Duloxetine augmented with gabapentin (as combined therapy)
- **Duloxetine augmented with amitriptyline (as combined therapy)** (ACTIVE_COMPARATOR) — Duloxetine augmented with amitriptyline (as combined therapy)
- **control** (NO_INTERVENTION) — control

## Interventions

- **Duloxetine alone** (DRUG) — 30 mg once daily for 1 week, then 60 mg once daily
- **Duloxetine augmented with gabapentin** (DRUG) — 30 mg once daily for 1 week, then 60 mg once daily 300 mg at bedtime
- **Duloxetine augmented with amitriptyline (as combined therapy)** (DRUG) — 10 to 25 mg once daily at bedtime 30 mg once daily for 1 week, then 60 mg once daily

## Primary Outcomes

- **The difference in numerical rating scale (NRS) daily pain measured during the final follow-up week (week 8) between the treatments.** _(time frame: 8 week)_

## Secondary Outcomes

- **Quality of Life Score** _(time frame: 8 week)_
- **Anxiety and depression Score** _(time frame: 8 weeks)_

## Locations (1)

- Beni-Seuf University Hospital, Banī Suwayf, Egypt — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.beni-seuf university hospital|banī suwayf||egypt` — added _(2026-05-12)_

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT06091553*  
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