---
title: Effect of Periodontal Treatment on Adipokine Levels
nct_id: NCT06225154
overall_status: COMPLETED
phase: NA
sponsor: Marmara University
study_type: INTERVENTIONAL
primary_condition: Periodontitis
countries: Finland, Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06225154.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06225154"
ct_last_update_post_date: 2024-01-30
last_seen_at: "2026-05-12T07:06:49.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effect of Periodontal Treatment on Adipokine Levels

**Official Title:** Effect of Non-Surgical Periodontal Treatment on Adipokine Levels in Diabetes Mellitus: A Controlled Clinical Trial

**NCT ID:** [NCT06225154](https://clinicaltrials.gov/study/NCT06225154)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 80
- **Lead Sponsor:** Marmara University
- **Collaborators:** University of Turku
- **Conditions:** Periodontitis, Diabetes Mellitus, Type 2
- **Start Date:** 2015-02
- **Completion Date:** 2016-11
- **CT.gov Last Update:** 2024-01-30

## Brief Summary

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).

## Detailed Description

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.

## Eligibility

- **Minimum age:** 20 Years
- **Maximum age:** 60 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Diabetes mellitus should be diagnosed for ≥1 year and HbA1c level should be at least %6,5
* Periodontitis should be diagnosed for at least 4 teeth with probing depth ≥5 mm with bleeding on probing (BOP) and also radiographic alveolar bone loss should be presence
* Presence of at least 15 teeth

Exclusion Criteria:

* Received antibiotic treatment in the previous 3 months
* Smokers
* Pregnancy and lactation
* Received periodontal treatment in the previous 6 months
* Presence of less than 15 teeth
* Having major diabetic complications
```

## Arms

- **No intervention** (NO_INTERVENTION) — Periodontally healthy subjects with type 2 diabetes mellitus or systemically healthy didn't have an initial periodontal treatment
- **Non-surgical periodontal treatment** (EXPERIMENTAL) — Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals for periodontitis patients systemically healthy or with type 2 diabetes mellitus.

## Interventions

- **Non-surgical periodontal treatment** (PROCEDURE) — Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.

## Primary Outcomes

- **Serum and Salivary Resistin Levels (pg/ml)** _(time frame: Change between baseline, 1 and 3 months after non-surgical periodontal treatment)_ — Serum and salivary resistin levels
- **Serum and Salivary Leptin Levels (pg/ml)** _(time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment)_ — Serum and salivary leptin levels
- **Serum and Salivary Visfatin Levels (pg/ml)** _(time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment)_ — Serum and salivary visfatin levels
- **Serum and saliva IL-1β levels (pg/ml)** _(time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment)_ — Serum and salivary IL-1β levels

## Secondary Outcomes

- **HbA1c ( %)** _(time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment)_

## Locations (2)

- Department of Periodontology, Institute of Dentistry, Turku University, Turku, Lemminkäisenkatu 2, Finland
- Marmara University, Faculty of Dentistry, Department of Periodontology, Istanbul, Maltepe, Turkey (Türkiye)

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.department of periodontology, institute of dentistry, turku university|turku|lemminkäisenkatu 2|finland` — added _(2026-05-12)_
- `locations.marmara university, faculty of dentistry, department of periodontology|istanbul|maltepe|turkey (türkiye)` — added _(2026-05-12)_

---

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