---
title: Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.
nct_id: NCT06239922
overall_status: NOT_YET_RECRUITING
sponsor: University of Macau
study_type: OBSERVATIONAL
primary_condition: Cognition Disorders in Old Age
countries: Macau
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06239922.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06239922"
ct_last_update_post_date: 2024-02-02
last_seen_at: "2026-05-12T07:09:01.885Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.

**Official Title:** Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults

**NCT ID:** [NCT06239922](https://clinicaltrials.gov/study/NCT06239922)

## Key Facts

- **Status:** NOT_YET_RECRUITING
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 300
- **Lead Sponsor:** University of Macau
- **Conditions:** Cognition Disorders in Old Age, Cognitive Decline, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change, Aging
- **Start Date:** 2024-02
- **Completion Date:** 2026-12-30
- **CT.gov Last Update:** 2024-02-02

## Brief Summary

The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.

## Detailed Description

The investigators will establish this assessment platform using a combination of methods, including interviews, surveys, and expert reviews.

Steps include adapting existing assessment methods to the Macau context, developing new cognitive and neural tasks, defining standardized procedures, seeking external expert input, conducting pilot tests, and validation processes, and refining both the platform and its accompanying manual.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Must be a local adult resident of Macau
* Age above 50 years for older adult cohort
* Younger adults individuals above 18 will be included as control comparators

Exclusion Criteria:

* History of neurological injury or disease
* Current use of medications that affect brain function or blood flow
* Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker)
* Claustrophobia
* Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm)
* Inability to provide informed consent
* Pregnancy
* Being under the legal age of adulthood (children)
* Incarcerated individuals (prisoners)
```

## Arms

- **Group 1** — Older adults
- **Group 2** — Younger adults

## Primary Outcomes

- **Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version** _(time frame: From February 2024 to January 2026)_ — The MoCA will be administered to derive a normative data set representative of the older adult population in Macau.
- **Normative Data for the Mini-Mental State Examination (MMSE)** _(time frame: From February 2024 to January 2026)_ — The MMSE will be administered to derive a normative data set representative of the older adult population in Macau.
- **Normative Scores for Computerized Neuropsychological Tasks** _(time frame: From February 2024 to January 2026)_ — Neuropsychological tasks will be employed to measure selective attention capacity and processing speed in the study cohort. These tasks will provide quantifiable data on the efficiency and accuracy of cognitive processing. The collective performance on these tasks will be used to establish benchmark values - including means, medians, and ranges - that define the normative standards for these cognitive abilities in the population.

## Secondary Outcomes

- **Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI)** _(time frame: From February 2024 to January 2026)_
- **Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS)** _(time frame: From February 2024 to January 2026)_
- **Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG)** _(time frame: From February 2024 to January 2026)_

## Locations (1)

- Centre for Cognitive and Brain Sciences of the University of Macau, Macao, Macao SAR, Macau

## Recent Field Changes (last 30 days)

- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.centre for cognitive and brain sciences of the university of macau|macao|macao sar|macau` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT06239922.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT06239922*  
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