---
title: Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
nct_id: NCT06356129
overall_status: ACTIVE_NOT_RECRUITING
phase: PHASE3
sponsor: Celgene
study_type: INTERVENTIONAL
primary_condition: Large B-cell Lymphoma
countries: United States, Argentina, Australia, Austria, Brazil, Bulgaria, Canada, Chile, China, Colombia, Czechia, Denmark, Finland, France, Germany, Greece, Hungary, India, Italy, Japan, Malaysia, Mexico, Netherlands, New Zealand, Norway, Poland, Portugal, Puerto Rico, Romania, Saudi Arabia, Singapore, Slovakia, South Korea, Spain, Sweden, Taiwan, Thailand, Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06356129.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06356129"
ct_last_update_post_date: 2026-02-12
last_seen_at: "2026-05-12T07:09:31.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma

**Official Title:** A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Golcadomide Plus R-CHOP Chemotherapy vs Placebo Plus R-CHOP Chemotherapy in Participants With Previously Untreated High-risk Large B-cell Lymphoma (GOLSEEK-1)

**NCT ID:** [NCT06356129](https://clinicaltrials.gov/study/NCT06356129)

## Key Facts

- **Status:** ACTIVE_NOT_RECRUITING
- **Phase:** PHASE3
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 850
- **Lead Sponsor:** Celgene
- **Conditions:** Large B-cell Lymphoma
- **Start Date:** 2024-06-19
- **Completion Date:** 2029-11-20
- **CT.gov Last Update:** 2026-02-12

## Brief Summary

The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL).

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria

\- Histologically confirmed (per local evaluation) diagnosis of de novo, previously untreated large B-cell lymphoma (LBCL) according to 2022 world health organization (WHO) classification including:

i) Diffuse large B-cell lymphoma (DLBCL), not otherwise specified \[including germinal center B-cell (GCB) and activated B-cell (ABC) types\]

ii) High-grade B-cell lymphoma, with MYC and BCL2 rearrangements (HGBL-MYC/BCL2 double-hit lymphomas)

iii) High-grade B-cell lymphoma, not otherwise specified

iv) T-cell/histiocyte/rich large B-cell lymphoma (THRLBCL)

v) Epstein-Barr virus + DLBCL

* International Prognostic Index (IPI) score 1 or 2 with lactate dehydrogenase (LDH) \> 1.3 x upper limit of normal (ULN) and/or bulky disease defined as single lesion of ≥ 7 cm OR IPI ≥ 3.
* Measurable disease defined by at least 1 fluorodeoxyglucose (FDG)-avid lesion for FDG-avid subtype and 1 bi-dimensionally measurable (\> 1.5 cm in longest diameter) disease by computed tomography (CT) or magnetic resonance imaging (MRI), as defined by the Lugano classification.
* Must have Ann Arbor Stage II-IV disease.

Exclusion Criteria

* Any significant medical condition, active infection, laboratory abnormality, or psychiatric illness that would prevent the participant from participating in the study.
* Any other subtype of lymphoma. Cases of primary mediastinal (thymic) large B-cell lymphoma (PMBCL), primary cutaneous DLBCL-leg type, Grade 3b FL, indolent lymphoma transformed to large B-cell lymphoma (LBCL), Anaplastic lymphoma kinase (ALK) positive large B-cell lymphoma, primary effusion lymphoma, and Burkitt lymphoma.
* Documented or suspected central nervous system (CNS) involvement by lymphoma.
* Other protocol-defined Inclusion/Exclusion criteria apply.
```

## Arms

- **Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone)** (EXPERIMENTAL)
- **Placebo + R-CHOP** (PLACEBO_COMPARATOR)

## Interventions

- **Golcadomide** (DRUG) — Specified dose on specified days
- **Placebo** (DRUG) — Specified dose on specified days
- **Rituximab** (DRUG) — Specified dose on specified days
- **Cyclophosphamide** (DRUG) — Specified dose on specified days
- **Doxorubicin** (DRUG) — Specified dose on specified days
- **Vincristine** (DRUG) — Specified dose on specified days
- **Prednisone** (DRUG) — Specified dose on specified days

## Primary Outcomes

- **Progression-free survival (PFS) assessed by the Investigator** _(time frame: Up to approximately 67 months)_

## Secondary Outcomes

- **PFS assessed by the Investigator** _(time frame: Up to approximately 67 months)_
- **Overall survival (OS)** _(time frame: Up to approximately 67 months)_
- **Event-free survival (EFS)** _(time frame: Up to approximately 67 months)_
- **Complete Metabolic Response assessed by the Independent Response Adjudication Committee (IRAC)** _(time frame: Up to approximately 18 weeks)_
- **Minimal residual disease (MRD) negativity rate** _(time frame: Up to approximately 18 weeks)_
- **Progression-free survival (PFS) assessed by the IRAC** _(time frame: Up to approximately 47 months)_
- **Objective response (OR) assessed by the Investigator** _(time frame: Up to approximately 18 weeks)_
- **Complete metabolic response (CMR) assessed by the Investigator** _(time frame: Up to approximately 18 weeks)_
- **PFS24 assessed by the Investigator 24 months after randomization** _(time frame: Up to 24 months)_
- **Duration of response (DoR)** _(time frame: Up to approximately 67 months)_
- **Second progression-free survival (PFS2) assessed by the Investigator** _(time frame: Up to approximately 67 months)_
- **Relative dose intensity (%)** _(time frame: Up to 18 weeks)_
- **Time from randomization to meaningful improvement in primary domains of interest in the European Organization for Research and Treatment of Cancer - Quality of Life C30 (EORTC QLQ-C30) Questionnaire** _(time frame: Up to approximately 67 months)_
- **Time from randomization to meaningful improvement in primary domains of interest in the Functional Assessment of Cancer Treatment-Lymphoma (FACT-LymS) Questionnaire** _(time frame: Up to approximately 67 months)_
- **Mean change from baseline in the EORTC QLQ-C30** _(time frame: Up to approximately 67 months)_
- **Mean change from baseline in the FACT-LymS** _(time frame: Up to approximately 67 months)_
- **Number of participants with Adverse Events (AEs)** _(time frame: Up to approximately 20 weeks)_
- **Number of participants with treatment-emergent adverse events (TEAEs)** _(time frame: Up to approximately 20 weeks)_
- **Number of participants with laboratory abnormalities** _(time frame: Up to approximately 20 weeks)_
- **Number of participants with vital sign abnormalities** _(time frame: Up to approximately 20 weeks)_

## Locations (325)

- Local Institution - 0014, Mobile, Alabama, United States
- Local Institution - 0477, Anchorage, Alaska, United States
- Local Institution - 0452, Phoenix, Arizona, United States
- Local Institution - 0342, San Francisco, California, United States
- Local Institution - 0497, Fort Myers, Florida, United States
- Local Institution - 0287, Jacksonville, Florida, United States
- Local Institution - 0415, Margate, Florida, United States
- Local Institution - 0045, Miami Beach, Florida, United States
- Local Institution - 0012, Pensacola, Florida, United States
- Local Institution - 0502, St. Petersburg, Florida, United States
- Local Institution - 0414, Tampa, Florida, United States
- Local Institution - 0192, West Palm Beach, Florida, United States
- Local Institution - 0485, Weston, Florida, United States
- Local Institution - 0515, Atlanta, Georgia, United States
- Local Institution - 0303, Atlanta, Georgia, United States
- Local Institution - 0182, Chicago, Illinois, United States
- Local Institution - 0048, Skokie, Illinois, United States
- Local Institution - 0461, Waukee, Iowa, United States
- Local Institution - 0031, Westwood, Kansas, United States
- Local Institution - 0436, Edgewood, Kentucky, United States
- Local Institution - 0408, Baton Rouge, Louisiana, United States
- Local Institution - 0478, Ann Arbor, Michigan, United States
- Local Institution - 0067, Minneapolis, Minnesota, United States
- Local Institution - 0203, Rochester, Minnesota, United States
- Local Institution - 0437, Kansas City, Missouri, United States
- Local Institution - 0466, Reno, Nevada, United States
- Local Institution - 0498, East Brunswick, New Jersey, United States
- Local Institution - 0480, Hackensack, New Jersey, United States
- Local Institution - 0049, Morristown, New Jersey, United States
- Local Institution - 0175, New Brunswick, New Jersey, United States
- Local Institution - 0190, Buffalo, New York, United States
- Local Institution - 0451, East Syracuse, New York, United States
- Local Institution - 0484, New York, New York, United States
- Local Institution - 0369, New York, New York, United States
- Local Institution - 0176, New York, New York, United States
- Local Institution - 0174, Chapel Hill, North Carolina, United States
- Local Institution - 0066, Massillon, Ohio, United States
- Local Institution - 0450, Tulsa, Oklahoma, United States
- Local Institution - 0179, Portland, Oregon, United States
- Local Institution - 0009, Pittsburgh, Pennsylvania, United States
- Local Institution - 0419, York, Pennsylvania, United States
- Local Institution - 0435, Fort Sam Houston, Texas, United States
- Local Institution - 0516, Houston, Texas, United States
- Local Institution - 0046, Houston, Texas, United States
- Local Institution - 0424, Houston, Texas, United States
- Local Institution - 0293, Richmond, Virginia, United States
- Local Institution - 0113, Buenos Aires, Buenos Aires F.D., Argentina
- Local Institution - 0421, Buenos Aires, Buenos Aires F.D., Argentina
- Local Institution - 0112, Buenos Aires, Argentina
- Local Institution - 0119, Buenos Aires, Argentina
- Local Institution - 0136, Buenos Aires, Argentina
- Local Institution - 0111, Córdoba, Argentina
- Local Institution - 0357, Gosford, New South Wales, Australia
- Local Institution - 0361, Sydney, New South Wales, Australia
- Local Institution - 0358, Westmead, New South Wales, Australia
- Local Institution - 0363, Tiwi, Northern Territory, Australia
- Local Institution - 0356, Birtinya, Queensland, Australia
- Local Institution - 0360, Southport, Queensland, Australia
- Local Institution - 0365, Frankston, Victoria, Australia
- Local Institution - 0362, Heidelberg, Victoria, Australia
- Local Institution - 0359, St Albans, Victoria, Australia
- Local Institution - 0364, Warrnambool, Victoria, Australia
- Local Institution - 0385, Wels, Upper Austria, Austria
- Local Institution - 0387, Linz, Austria
- Local Institution - 0386, Vienna, Austria
- Local Institution - 0255, Fortaleza, Ceará, Brazil
- Local Institution - 0297, Lago Sul, Federal District, Brazil
- Local Institution - 0256, Goiânia, Goiás, Brazil
- Local Institution - 0302, Curitiba, Paraná, Brazil
- Local Institution - 0296, Niterói, Rio de Janeiro, Brazil
- Local Institution - 0304, Natal, Rio Grande do Norte, Brazil
- Local Institution - 0253, Porto Alegre, Rio Grande do Sul, Brazil
- Local Institution - 0246, Chapecó, Santa Catarina, Brazil
- Local Institution - 0247, Joinville, Santa Catarina, Brazil
- Local Institution - 0250, Barretos, São Paulo, Brazil
- Local Institution - 0249, Jaú, São Paulo, Brazil
- Local Institution - 0301, São José do Rio Preto, São Paulo, Brazil
- Local Institution - 0248, São Paulo, São Paulo, Brazil
- Local Institution - 0316, São Paulo, São Paulo, Brazil
- Local Institution - 0298, Rio de Janeiro, Brazil
- Local Institution - 0294, São Paulo, Brazil
- Local Institution - 0252, São Paulo, Brazil
- Local Institution - 0317, São Paulo, Brazil
- Local Institution - 0251, São Paulo, Brazil
- Local Institution - 0393, Plovdiv, Bulgaria
- Local Institution - 0392, Sofia, Bulgaria
- Local Institution - 0394, Sofia, Bulgaria
- Local Institution - 0091, Victoria, British Columbia, Canada
- Local Institution - 0153, Montreal, Quebec, Canada
- Local Institution - 0073, Montreal, Quebec, Canada
- Local Institution - 0004, Sherbrooke, Quebec, Canada
- Local Institution - 0106, Santiago, Santiago Metropolitan, Chile
- Local Institution - 0107, Santiago, Santiago Metropolitan, Chile
- Local Institution - 0108, Santiago, Santiago Metropolitan, Chile
- Local Institution - 0110, Santiago, Santiago Metropolitan, Chile
- Local Institution - 0459, Santiago, Santiago Metropolitan, Chile
- Local Institution - 0164, Viña del Mar, Valparaiso, Chile
- Local Institution - 0195, Beijing, Beijing Municipality, China
- Local Institution - 0236, Chongqing, Chongqing Municipality, China
- Local Institution - 0196, Chongqing, Chongqing Municipality, China
- Local Institution - 0274, Fuzhou, Fujian, China
- Local Institution - 0157, Xiamen, Fujian, China
- Local Institution - 0133, Guangzhou, Guangdong, China
- Local Institution - 0240, Guangzhou, Guangdong, China
- Local Institution - 0338, Nanning, Guangxi, China
- Local Institution - 0239, Harbin, Heilongjiang, China
- Local Institution - 0238, Zhengzhou, Henan, China
- Local Institution - 0346, Wuhan, Hubei, China
- Local Institution - 0214, Wuhan, Hubei, China
- Local Institution - 0275, Changsha, Hunan, China
- Local Institution - 0156, Suzhou, Jiangsu, China
- Local Institution - 0237, Nanchang, Jiangxi, China
- Local Institution - 0241, Nanchang, Jiangxi, China
- Local Institution - 0291, Changchun, Jilin, China
- Local Institution - 0334, Shenyang, Liaoning, China
- Local Institution - 0169, Shenyang, Liaoning, China
- Local Institution - 0242, Jinan, Shandong, China
- Local Institution - 0344, Jinan, Shandong, China
- Local Institution - 0132, Shanghai, Shanghai Municipality, China
- Local Institution - 0339, Shanghai, Shanghai Municipality, China
- Local Institution - 0234, Taiyuan, Shanxi, China
- Local Institution - 0141, Chengdu, Sichuan, China
- Local Institution - 0470, Tianjin, Tianjin Municipality, China
- Local Institution - 0467, Ürümqi, Xinjiang, China
- Local Institution - 0197, Hangzhou, Zhejiang, China
- Local Institution - 0483, Hangzhou, Zhejiang, China
- Local Institution - 0457, Wenzhou, Zhejiang, China
- Local Institution - 0129, Bogotá, Bogota D.C., Colombia
- Local Institution - 0130, Bogota, Cundinamarca, Colombia
- Local Institution - 0105, Brno, Brno-město, Czechia
- Local Institution - 0104, Hradec Králové, Hradec Králové, Czechia
- Local Institution - 0102, Olomouc, Olomouc Region, Czechia
- Local Institution - 0120, Pilsen, Plzeň Region, Czechia
- Local Institution - 0103, Prague, Praha 10, Czechia
- Local Institution - 0243, Prague, Czechia
- Local Institution - 0285, Aarhus, Central Jutland, Denmark
- Local Institution - 0284, Odense, Region Syddanmark, Denmark
- Local Institution - 0281, Oulu, North Ostrobothnia, Finland
- Local Institution - 0283, Kuopio, Northern Savonia, Finland
- Local Institution - 0282, Turku, Southwest Finland, Finland
- Local Institution - 0280, Helsinki, Finland
- Local Institution - 0083, Nice, Alpes-Maritimes, France
- Local Institution - 0084, Strasbourg, Alsace, France
- Local Institution - 0090, Bordeaux, Aquitaine, France
- Local Institution - 0324, Pessac, Aquitaine, France
- Local Institution - 0087, Marseille, Bouches-du-Rhône, France
- Local Institution - 0292, Dijon, Côte-d'Or, France
- Local Institution - 0486, Besançon, Doubs, France
- Local Institution - 0332, Brest, Finistère, France
- Local Institution - 0202, Lille, Hauts-de-France, France
- Local Institution - 0335, Saint-Cloud, Hauts-de-Seine, France
- Local Institution - 0079, Tours, Indre-et-Loire, France
- Local Institution - 0223, La Tronche, Isère, France
- Local Institution - 0323, Saint-Pierre, La Réunion, France
- Local Institution - 0074, Montpellier, Languedoc-Roussillon, France
- Local Institution - 0081, Lille, Nord, France
- Local Institution - 0325, Nantes, Pays de la Loire Region, France
- Local Institution - 0321, Saint Priest En Jarez, Pays de la Loire Region, France
- Local Institution - 0089, Pierre-Bénite, Rhône, France
- Local Institution - 0200, Créteil, Val-de-Marne, France
- Local Institution - 0076, Villejuif, Val-de-Marne, France
- Local Institution - 0306, Poitiers, Vienne, France
- Local Institution - 0244, Bayonne, France
- Local Institution - 0315, Caen, France
- Local Institution - 0077, Paris, France
- Local Institution - 0511, Ulm, Baden-Wurttemberg, Germany
- Local Institution - 0383, Augsburg, Bavaria, Germany
- Local Institution - 0512, Bayreuth, Bavaria, Germany
- Local Institution - 0505, Erlangen, Bavaria, Germany
- Local Institution - 0507, Langen, Hesse, Germany
- Local Institution - 0513, Hanover, Lower Saxony, Germany
- Local Institution - 0384, Koblenz, Rhineland-Palatinate, Germany
- Local Institution - 0504, Halle, Saxony-Anhalt, Germany
- Local Institution - 0506, Lübeck, Schleswig-Holstein, Germany
- Local Institution - 0508, Berlin, Germany
- Local Institution - 0503, Cottbus, Germany
- Local Institution - 0510, Dresden, Germany
- Local Institution - 0370, Essen, Germany
- Local Institution - 0398, Alexandroupoli, Anatolikí Makedonía Kai Thráki, Greece
- Local Institution - 0399, Athens, Attikí, Greece
- Local Institution - 0396, Athens, Attikí, Greece
- Local Institution - 0397, Chaïdári, Attikí, Greece
- Local Institution - 0395, Ioannina, Ípeiros, Greece
- Local Institution - 0266, Debrecen, Hajdú-Bihar, Hungary
- Local Institution - 0162, Kaposvár, Somogy County, Hungary
- Local Institution - 0353, Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
- Local Institution - 0161, Szombathely, Vas County, Hungary
- Local Institution - 0163, Budapest, Hungary
- Local Institution - 0160, Budapest, Hungary
- Local Institution - 0411, Belagavi, Karnataka, India
- Local Institution - 0430, Kochi, Kerala, India
- Local Institution - 0154, Mumbai, Maharashtra, India
- Local Institution - 0433, New Delhi, National Capital Territory of Delhi, India
- Local Institution - 0469, New Delhi, National Capital Territory of Delhi, India
- Local Institution - 0413, Howrah, West Bengal, India
- Local Institution - 0410, New Town, West Bengal, India
- Local Institution - 0495, Ravenna, Emilia-Romagna, Italy
- Local Institution - 0493, Rome, Lazio, Italy
- Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicily, Italy
- Local Institution - 0496, Novara, Italy
- _and 125 more_

## Recent Field Changes (last 30 days)

- `locations.local institution - 0368|sapporo|hokkaido|japan` — added _(2026-05-12)_
- `locations.local institution - 0327|sapporo|hokkaido|japan` — added _(2026-05-12)_
- `locations.local institution - 0273|amagasaki|hyōgo|japan` — added _(2026-05-12)_
- `locations.local institution - 0328|himeji|hyōgo|japan` — added _(2026-05-12)_
- `locations.local institution - 0270|kanazawa|ishikawa-ken|japan` — added _(2026-05-12)_
- `locations.local institution - 0343|morioka|iwate|japan` — added _(2026-05-12)_
- `locations.local institution - 0170|isehara|kanagawa|japan` — added _(2026-05-12)_
- `locations.local institution - 0333|yokohama|kanagawa|japan` — added _(2026-05-12)_
- `locations.local institution - 0313|fukuoka||japan` — added _(2026-05-12)_
- `locations.local institution - 0320|sendai|miyagi|japan` — added _(2026-05-12)_
- `locations.local institution - 0166|sakai|osaka|japan` — added _(2026-05-12)_
- `locations.local institution - 0269|hidaka|saitama|japan` — added _(2026-05-12)_
- `locations.local institution - 0288|nagaizumi-cho,sunto-gun|shizuoka|japan` — added _(2026-05-12)_
- `locations.local institution - 0350|bunkyo-ku|tokyo|japan` — added _(2026-05-12)_
- `locations.local institution - 0268|itabashiku|tokyo|japan` — added _(2026-05-12)_
- `locations.local institution - 0331|chūō|yamanashi|japan` — added _(2026-05-12)_
- `locations.local institution - 0348|fukuoka||japan` — added _(2026-05-12)_
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- `locations.local institution - 0272|hiroshima||japan` — added _(2026-05-12)_
- `locations.local institution - 0171|kumamoto||japan` — added _(2026-05-12)_
- `locations.local institution - 0215|kyoto||japan` — added _(2026-05-12)_
- `locations.local institution - 0329|okayama||japan` — added _(2026-05-12)_
- `locations.local institution - 0322|osaka||japan` — added _(2026-05-12)_
- `locations.local institution - 0347|osaka||japan` — added _(2026-05-12)_
- `locations.local institution - 0167|yamagata||japan` — added _(2026-05-12)_
- `locations.local institution - 0453|lembah pantai|kuala lumpur|malaysia` — added _(2026-05-12)_
- `locations.local institution - 0432|george town|pulau pinang|malaysia` — added _(2026-05-12)_
- `locations.local institution - 0431|kuching|sarawak|malaysia` — added _(2026-05-12)_
- `locations.local institution - 0449|ampang|selangor|malaysia` — added _(2026-05-12)_
- `locations.local institution - 0122|mexico city|dif|mexico` — added _(2026-05-12)_
- `locations.local institution - 0121|mexico city|dif|mexico` — added _(2026-05-12)_
- `locations.local institution - 0128|mexico city|mexico city|mexico` — added _(2026-05-12)_
- `locations.local institution - 0126|mexico city|mexico city|mexico` — added _(2026-05-12)_
- `locations.local institution - 0127|morelia|michoacán|mexico` — added _(2026-05-12)_
- `locations.local institution - 0139|monterrey|nuevo león|mexico` — added _(2026-05-12)_
- `locations.local institution - 0125|oaxaca city|oaxaca|mexico` — added _(2026-05-12)_
- `locations.local institution - 0124|puebla city||mexico` — added _(2026-05-12)_
- `locations.local institution - 0500|leiden|south holland|netherlands` — added _(2026-05-12)_
- `locations.local institution - 0499|groningen||netherlands` — added _(2026-05-12)_
- `locations.local institution - 0367|dunedin|otago|new zealand` — added _(2026-05-12)_
- `locations.local institution - 0366|hamilton|waikato region|new zealand` — added _(2026-05-12)_
- `locations.local institution - 0462|auckland||new zealand` — added _(2026-05-12)_
- `locations.local institution - 0391|oslo||norway` — added _(2026-05-12)_
- `locations.local institution - 0388|skórzewo|greater poland voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0336|bydgoszcz|kuyavian-pomeranian voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0201|krakow|lesser poland voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0337|lublin|lublin voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0443|warsaw|masovian voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0330|katowice|silesian voivodeship|poland` — added _(2026-05-12)_
- `locations.local institution - 0286|lisbon||portugal` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT06356129.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT06356129*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*