---
title: Home-based Balance Training in Adults With Multiple Sclerosis
nct_id: NCT06412003
overall_status: NOT_YET_RECRUITING
phase: NA
sponsor: University of Vermont
study_type: INTERVENTIONAL
primary_condition: Multiple Sclerosis
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06412003.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06412003"
ct_last_update_post_date: 2024-05-16
last_seen_at: "2026-05-12T06:16:31.814Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Home-based Balance Training in Adults With Multiple Sclerosis

**Official Title:** Home-based Balance Training With Family Member Support in Adults With Multiple Sclerosis: A Feasibility Single-group Pretest-posttest Design

**NCT ID:** [NCT06412003](https://clinicaltrials.gov/study/NCT06412003)

## Key Facts

- **Status:** NOT_YET_RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 30
- **Lead Sponsor:** University of Vermont
- **Conditions:** Multiple Sclerosis, Multiple Sclerosis, MS
- **Start Date:** 2024-07-01
- **Completion Date:** 2025-05-31
- **CT.gov Last Update:** 2024-05-16

## Brief Summary

This single-group pretest-posttest study aims to examine the feasibility domains in response to 12 weeks of home-based balance training in persons with multiple sclerosis (MS). The feasibility domains include 1) process (e.g., recruitment, attendance, adherence rate), 2) resources (e.g., total monetary costs), 3) management (e.g., assessment time), and 4) scientific outcomes (adverse events, intervention acceptability, satisfaction, treatment effects). Moreover, this study aims to evaluate physical function (i.e., balance, mobility, dual-task ability), cognitive function (i.e., cognitive processing speed, verbal memory, visuospatial memory), real-world ambulation (i.e., gait speed, gait variability, gait quantity), and self-report questionnaires (fatigue, fear of falling, walking disability, dual-tasking difficulty). Our proposed intervention is expected to deliver a feasible and accessible exercise modality for balance and cognitive improvement in persons with multiple sclerosis.

## Detailed Description

Acknowledging the complex system of balance, this home-based balance training aims to address comprehensive balance control components, such as static balance, limit of stability, postural response (reactive balance), anticipatory postural transition, weight shifting, stability in gait, and stepping exercise. These balance components will be encompassed in every session to train balance function comprehensively. Exercise program will be progressed by varying sensory integrations, base of support, and simultaneous motor-cognitive tasks (i.e., dual-task).

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Physician-diagnosed MS
* Ages 18-75 years
* Patient Determined Disease Steps (PDDS) scale score between 2-5 (i.e., gait disability-late cane)
* Able to participate in exercise (i.e., one or fewer affirmatives on the Physical Activity Readiness Questionnaire (PAR-Q+))
* Have a webcam on a device at least the size of a full tablet (i.e., larger than a smartphone)
* Have an exercise supporter (e.g., spouse or family member) who is willing to participate in the intervention
* Not currently participating in any balance-related exercise program

Exclusion Criteria:

* Cognitively unable to read and sign informed consent form and follow verbally delivered screening assessment
* Unable to communicate in English
```

## Arms

- **Home-based balance training group** (EXPERIMENTAL) — Participants will perform the home-based balance training program for 30-40 minutes per session, 3 days per week for 12 weeks not including the two weeks of education and familiarization.

## Interventions

- **Home-based balance training** (BEHAVIORAL) — This is a family member supported home-based balance training program designed for community-dwelling people with MS to improve balance and walking abilities as well as cognitive functions. The intervention program aims to have participants with MS reach high-intensity balance tasks during the program. A bi-weekly two-on-one, semi-structured, video-chat session with participants and their exercise supporter and research team will be conducted using videoconferencing techniques (e.g., Zoom, Skype, or Facetime).

## Primary Outcomes

- **Feasibility outcome: Process** _(time frame: From enrollment to completion of posttest (12weeks))_ — This study will assess 1) recruitment rate (the number of participants screened divided by the total number of participants contacted), 2) eligibility rate (the number of participants eligible divided by total number of participants screened), 3) adherence rate (the percentages of withdrawals and completions), and 4) attendance rate (the percentages of targeted exercise sessions completed by intervention group participants who completed the study). These 4 rates will be employed to assess the feasibility of process.
- **Feasibility outcome: Resources** _(time frame: From enrollment to completion of posttest (12weeks))_ — The total expenses of the study will be calculated, including materials (e.g., exercise equipment) and participant remuneration.
- **Feasibility outcome: Management** _(time frame: From enrollment to completion of posttest (12weeks))_ — This study will document all videoconferencing time and baseline and follow-up assessment time. The measures will assess the time management of the intervention.
- **Feasibility outcome: Participant burden/satisfaction** _(time frame: After completion of posttest (12weeks))_ — This study will assess participant burden and satisfaction through a questionnaire after the completion of the intervention. The questionnaire consists of 12 closed-ended and 2 open-ended items
- **Feasibility outcome: Adverse event** _(time frame: From enrollment to completion of posttest (12weeks))_ — This study will record adverse event occurred during the intervention program.
- **Feasibility outcome: Intervention acceptability** _(time frame: From enrollment to completion of posttest (12weeks))_ — This study will assess whether participants meet the prescribed exercise doses throughout the intervention program.
- **Feasibility outcome: exercise intensity acceptability/compliance** _(time frame: From enrollment to completion of posttest (12weeks))_ — This study will assess whether participants adhere to a prescribed exercise intensity dose throughout the intervention program. An exercise log will be employed to assess exercise intensity acceptability.

## Secondary Outcomes

- **Changes in balance as measured by Timed Up and Go/Dual-task Timed Up and Go** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in functional mobility as measured by 5-time sit-to-stand** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in static balance as measured by4-stage static balance tests** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in cognitive function as measured by Brief International Cognitive Assessments for MS (BICAMS)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in community mobility perception as measured by Environmental Analysis of Mobility Questionnaire (EAMQ)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in fear of falling as measured by Fall Efficacy Scale-International (FES-I)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in self-reported walking disability as measured by Multiple Sclerosis Walking Scale-12v2 (MSWS-12v2)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in self-reported dual-tasking difficulty as measured by Dual-task Impact on Daily-Living Activities Questionnaire (DIDA-Q)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in self-reported fatigue as measured by Fatigue Scale for Motor and Cognitive Functions (FSMC)** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in Real-world ambulation metrics as measured by tri-axial accelerometer** _(time frame: Baseline and after completion of an intervention (12weeks))_
- **Changes in exercise intention** _(time frame: Baseline and after completion of an intervention (12weeks))_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT06412003.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT06412003*  
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