---
title: Acute Effects of Cryotherapy on Muscle Properties
nct_id: NCT06608836
overall_status: NOT_YET_RECRUITING
phase: NA
sponsor: Istanbul University - Cerrahpasa
study_type: INTERVENTIONAL
primary_condition: Cryotherapy Effect
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06608836.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06608836"
ct_last_update_post_date: 2024-09-23
last_seen_at: "2026-05-12T06:33:28.413Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Acute Effects of Cryotherapy on Muscle Properties

**Official Title:** Acute Effects of Cryotherapy on Muscle Mechanical Properties and Muscle Activation Changes

**NCT ID:** [NCT06608836](https://clinicaltrials.gov/study/NCT06608836)

## Key Facts

- **Status:** NOT_YET_RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 52
- **Lead Sponsor:** Istanbul University - Cerrahpasa
- **Collaborators:** Okan University
- **Conditions:** Cryotherapy Effect
- **Start Date:** 2024-12-15
- **Completion Date:** 2025-01-15
- **CT.gov Last Update:** 2024-09-23

## Brief Summary

The main aim of this study is to investigate the acute effects of cryotherapy on muscle mechanical properties, muscle strength, and activation changes in healthy subjects.

## Detailed Description

What changes occur in muscle stiffness following cryotherapy application? How does cryotherapy affect muscle strength? How does cryotherapy impact muscle activation? Are there differences in muscle mechanical properties, muscle strength, and muscle activation between different cryotherapy methods (ice massage and cold spray)? How do the effects of cryotherapy on muscle mechanical properties, muscle strength, and muscle activation change over time?

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 35 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Being willing to participate in the study
* Being between the ages of 18 and 35

Exclusion Criteria:

* Having undergone orthopedic surgery involving the lower extremity
```

## Arms

- **Group 1** (EXPERIMENTAL) — An ice massage will be applied to the quadrices muscle for a duration of 3 minutes.
- **Group 2** (EXPERIMENTAL) — A cold spray application will be performed to the quadrices muscle.

## Interventions

- **an ice massage** (OTHER) — an ice massage
- **the cold spray** (OTHER) — the cold spray

## Primary Outcomes

- **myoton pro device** _(time frame: 3 months)_ — elasticity of muscle will assess by myoton pro device
- **muscle strength** _(time frame: 3 months)_ — muscle strength will assess by dynanometer
- **electromyography device** _(time frame: 3 months)_ — activation of quadriceps muscle will assess by electromyography device

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT06608836.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT06608836*  
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