--- title: Prospective Observational Multicenter Study of Patients With AH and CKD Markers in Kazakhstan (PROGRESS-CKD) nct_id: NCT06744335 overall_status: RECRUITING sponsor: AstraZeneca study_type: OBSERVATIONAL primary_condition: Rate of CKD Diagnosis in Patients With AH and CKD Markers countries: Kazakhstan canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06744335.md" clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06744335" ct_last_update_post_date: 2026-04-08 last_seen_at: "2026-05-12T07:34:39.969Z" source: ClinicalTrials.gov (mirrored, no enrichment) --- # Prospective Observational Multicenter Study of Patients With AH and CKD Markers in Kazakhstan (PROGRESS-CKD) **Official Title:** Prospective Observational Multicenter Study of Patients With Arterial Hypertension and Chronic Kidney Disease Markers in Kazakhstan (PROGRESS-CKD) **NCT ID:** [NCT06744335](https://clinicaltrials.gov/study/NCT06744335) ## Key Facts - **Status:** RECRUITING - **Study Type:** OBSERVATIONAL - **Target Enrollment:** 1282 - **Lead Sponsor:** AstraZeneca - **Conditions:** Rate of CKD Diagnosis in Patients With AH and CKD Markers, Demographic and Clinical Characteristics for Those Patients, Routine Therapy Before and After the Diagnosis of CKD - **Start Date:** 2025-01-20 - **Completion Date:** 2026-08-20 - **CT.gov Last Update:** 2026-04-08 ## Brief Summary Multicenter, non-interventional PRospective Observational study with retrospective analysis to describe the rate of CKD diaGnosis in patients with aRtErial hypErtenSion and CKD markerS in Kazakhstan ## Detailed Description Primary endpoints: The proportion of patients with markers of chronic kidney disease (CKD) among patients with arterial hypertension such as: albuminuria/proteinuria; GFR \<60 ml/min/1.73 m2 (CFR categories C3a-C5). Secondary endpoints: The following secondary endpoints will be evaluated in all patients with AH and markers of CKD included in the study (Full Analysis Sampling - FAS) (Secondary Aim 1) and in the subgroup of patients with a diagnosis of CKD confirmed during the study (Modified Full Analysis Sampling - mFAS), i.e., at Visit 1 or Visit 2 (Secondary Aim 2): ## Eligibility - **Minimum age:** 18 Years - **Sex:** ALL - **Healthy Volunteers:** No ``` Inclusion Criteria: Age ≥18 years at the time of inclusion; * Patient signed and dated written informed consent form (ICF) in accordance with ICH GCP and local legislation prior to inclusion in the study for the prospective observational cohort; * Established diagnosis of hypertension, diagnosed in accordance with current clinical guidelines for hypertension, i.e. in adults, i.e. systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg. when measured at two different visits * Laboratory markers of CKD (eGFR \<60 mL/min/1.73 m2 and/or albuminuria/proteinuria\*) measured during the period ≤12 months prior to inclusion in the study and persisting ≥3 months between two measurements without a recorded diagnosis of CKD in the primary medical record prior to inclusion; \* any of the following: urine albumin/creatinine ratio (UACR) ≥30 mg/g (3 mg/mmol), Urine protein-creatinine ratio (uPCR) ≥150 mg/g (15 mg/mmol), albuminuria ≥30 mg/d or Urine protein-creatinine ratio (uPCR) ≥0.15 mg/d. * Absence of documented diagnosis of CKD in the patient's medical records prior to inclusion in the study Exclusion Criteria: * Absence of a signed ICF in patients in the prospective follow-up group * Participation in any randomized controlled trial within 3 months prior to inclusion in this study or during participation in this study * An established diagnosis of type 1 or type 2 diabetes mellitus. * Diagnosis of symptomatic chronic heart failure (CHF), NYHA functional class III-IV, documented in the patient's medical records * Diagnosis of AH of secondary genesis ``` ## Primary Outcomes - **The proportion of patients with markers of chronic kidney disease (CKD) among patients with arterial hypertension such as: albuminuria/proteinuria; GFR <60 ml/min/1.73 m2 (CFR categories C3a-C5).** _(time frame: 16 months)_ — The proportion of patients with markers of chronic kidney disease (CKD) among patients with arterial hypertension such as: albuminuria/proteinuria; GFR \<60 ml/min/1.73 m2 (CFR categories C3a-C5). ## Secondary Outcomes - **1. Frequency of microalbuminuria, proteinuria, reduced glomerular filtration rate (GFR <60 ml/min/1.73 m²) and other markers of kidney damage in patients with arterial hypertension.** _(time frame: 16 months)_ - **2. Proportion of patients with various risk factors (age, gender, BMI, bad habits, blood pressure, cardiovascular risks) for the development and progression of CKD in patients with arterial hypertension.** _(time frame: 16 months)_ - **3.Proportion of patients with various clinical characteristics, such as: • Average and median duration of AH years • Patients with different stages of AH and categories of cardiovascular risk.• Patients with uncontrolled and resistant hypertension.** _(time frame: 16 months)_ - **4. The proportion of patients taking the following groups of drugs for the treatment of AH before inclusion in the study and during participation in the study: • ACE • Alfa or Beta-blockers; • ARBs •CCB • Diuretics • ARNI• Centrally acting drugs; • MRA.** _(time frame: 16 months)_ - **5. Proportion of patients with: • concomitant CVD and complications of AF/AFL, ventricular arrhythmias; CHD; MI; cerebrovascular diseases; stroke, TIA; • other concomitant diseases (in general and for each disease).** _(time frame: 16 months)_ ## Locations (29) - Ordabasy Central District Hospital, Temirlanovka, Turkistan Oblast, Kazakhstan — _RECRUITING_ - City Polyclinic No. 2, Aktobe, Kazakhstan — _WITHDRAWN_ - City Polyclinic No. 4, Aktobe, Kazakhstan — _RECRUITING_ - City Cardiology Center, Almaty, Kazakhstan — _RECRUITING_ - Interna Clinic, Scientific Centre for Internal Medicine LLP, Almaty, Kazakhstan — _NOT_YET_RECRUITING_ - JSC Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan — _RECRUITING_ - LLP Almaty Sema Hospital, Almaty, Kazakhstan — _RECRUITING_ - Municipal state enterprise with the right of economic management City polyclinic No. 5, Almaty, Kazakhstan — _RECRUITING_ - National Hospital of Medical Center of the Presidents Affairs Administration of the Republic of Kazakhstan, Almaty, Kazakhstan — _RECRUITING_ - AIS Clinic, Astana, Kazakhstan — _RECRUITING_ - City Polyclinic No. 2, Astana, Kazakhstan — _RECRUITING_ - Family Health Center Shipager, Astana, Kazakhstan — _RECRUITING_ - Green Clinic, Astana, Kazakhstan — _RECRUITING_ - Medical Center Hospital of the President's Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan — _RECRUITING_ - Medical Center Zhanuya, Astana, Kazakhstan — _RECRUITING_ - Onege Family Health and Happiness Centre, LLP, Astana, Kazakhstan — _RECRUITING_ - State Enterprise on the Right of Economic Management City Polyclinic No. 5 Astana, Astana, Kazakhstan — _RECRUITING_ - State Enterprise on the Right of Economic Management City Polyclinic No. 6 Astana, Astana, Kazakhstan — _RECRUITING_ - UMC Diagnostic Centre, Astana, Kazakhstan — _RECRUITING_ - Enbekshikazakh Multidisciplinary Interdistrict Hospital, Esik, Kazakhstan — _RECRUITING_ - City Polyclinic No. 1, Karaganda, Kazakhstan — _RECRUITING_ - City Polyclinic No. 3, Karaganda, Kazakhstan — _RECRUITING_ - Communal State Enterprise Polyclinic No. 4 of Kostanay City, Kostanay, Kazakhstan — _NOT_YET_RECRUITING_ - Communal State Enterprise on the right of economic management City Polyclinic No. 7, Semey, Kazakhstan — _RECRUITING_ - LLP Sau Zhurek Healthy Heart, Shymkent, Kazakhstan — _NOT_YET_RECRUITING_ - NJSC Heart Centre Shymkent, Shymkent, Kazakhstan — _RECRUITING_ - IE Dr.Selina, Stepnogorsk, Kazakhstan — _RECRUITING_ - Clinical and Diagnostic Center of the International Kazakh-Turkish University named after Khoja Ahmet Yasawi, Turkestan, Kazakhstan — _ACTIVE_NOT_RECRUITING_ - State Enterprise on the Right of Economic Management Zhambyl District Central Hospital, Uzynaghash, Kazakhstan — _RECRUITING_ ## Recent Field Changes (last 30 days) - `status.lastUpdatePostDate` — added _(2026-05-12)_ - `status.overallStatus` — added _(2026-05-12)_ - `status.primaryCompletionDate` — added _(2026-05-12)_ - `status.completionDate` — added _(2026-05-12)_ - `design.enrollmentCount` — added _(2026-05-12)_ - `eligibility.criteria` — added _(2026-05-12)_ - `eligibility.minAge` — added _(2026-05-12)_ - `eligibility.sex` — added _(2026-05-12)_ - `outcomes.primary` — added _(2026-05-12)_ - `outcomes.secondary` — added _(2026-05-12)_ - `sponsor.lead` — added _(2026-05-12)_ - `results.hasResults` — added _(2026-05-12)_ - `locations.ordabasy central district hospital|temirlanovka|turkistan oblast|kazakhstan` — added _(2026-05-12)_ - `locations.city polyclinic no. 2|aktobe||kazakhstan` — added _(2026-05-12)_ - `locations.city polyclinic no. 4|aktobe||kazakhstan` — added _(2026-05-12)_ - `locations.city cardiology center|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.interna clinic, scientific centre for internal medicine llp|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.jsc research institute of cardiology and internal diseases|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.llp almaty sema hospital|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.municipal state enterprise with the right of economic management city polyclinic no. 5|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.national hospital of medical center of the presidents affairs administration of the republic of kazakhstan|almaty||kazakhstan` — added _(2026-05-12)_ - `locations.ais clinic|astana||kazakhstan` — added _(2026-05-12)_ - `locations.city polyclinic no. 2|astana||kazakhstan` — added _(2026-05-12)_ - `locations.family health center shipager|astana||kazakhstan` — added _(2026-05-12)_ - `locations.green clinic|astana||kazakhstan` — added _(2026-05-12)_ - `locations.medical center hospital of the president's affairs administration of the republic of kazakhstan|astana||kazakhstan` — added _(2026-05-12)_ - `locations.medical center zhanuya|astana||kazakhstan` — added _(2026-05-12)_ - `locations.onege family health and happiness centre, llp|astana||kazakhstan` — added _(2026-05-12)_ - `locations.state enterprise on the right of economic management city polyclinic no. 5 astana|astana||kazakhstan` — added _(2026-05-12)_ - `locations.state enterprise on the right of economic management city polyclinic no. 6 astana|astana||kazakhstan` — added _(2026-05-12)_ - `locations.umc diagnostic centre|astana||kazakhstan` — added _(2026-05-12)_ - `locations.enbekshikazakh multidisciplinary interdistrict hospital|esik||kazakhstan` — added _(2026-05-12)_ - `locations.city polyclinic no. 1|karaganda||kazakhstan` — added _(2026-05-12)_ - `locations.city polyclinic no. 3|karaganda||kazakhstan` — added _(2026-05-12)_ - `locations.communal state enterprise polyclinic no. 4 of kostanay city|kostanay||kazakhstan` — added _(2026-05-12)_ - `locations.communal state enterprise on the right of economic management city polyclinic no. 7|semey||kazakhstan` — added _(2026-05-12)_ - `locations.llp sau zhurek healthy heart|shymkent||kazakhstan` — added _(2026-05-12)_ - `locations.njsc heart centre shymkent|shymkent||kazakhstan` — added _(2026-05-12)_ - `locations.ie dr.selina|stepnogorsk||kazakhstan` — added _(2026-05-12)_ - `locations.clinical and diagnostic center of the international kazakh-turkish university named after khoja ahmet yasawi|turkestan||kazakhstan` — added _(2026-05-12)_ - `locations.state enterprise on the right of economic management zhambyl district central hospital|uzynaghash||kazakhstan` — added _(2026-05-12)_ --- *Canonical: https://parkinsonspathways.com/agent/trials/NCT06744335.md* *Source data (authoritative): https://clinicaltrials.gov/study/NCT06744335* *This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*