---
title: Kidney Function in Obese Women
nct_id: NCT06905236
overall_status: COMPLETED
phase: NA
sponsor: Wissal Abassi
study_type: INTERVENTIONAL
primary_condition: Kidney Function Tests
countries: Tunisia
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT06905236.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06905236"
ct_last_update_post_date: 2025-04-01
last_seen_at: "2026-05-12T07:20:56.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Kidney Function in Obese Women

**Official Title:** Kidney Function Markers in Postmenopausal Obese Women: Response to Aerobic Training

**NCT ID:** [NCT06905236](https://clinicaltrials.gov/study/NCT06905236)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 36
- **Lead Sponsor:** Wissal Abassi
- **Conditions:** Kidney Function Tests
- **Start Date:** 2024-09-23
- **Completion Date:** 2024-12-22
- **CT.gov Last Update:** 2025-04-01

## Brief Summary

The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is:

Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers.

Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.

## Detailed Description

The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine \[sCr\], blood urea nitrogen \[BUN\], serum uric acid \[sUA\] and Glomerular Filtration Rate \[GFR\] and white blood cells (WBC) count and its specific subpopulations (neutrophils \[NEU\], lymphocytes \[LYM\], monocytes \[MON\], eosinophils \[EOSI\] and basophils \[BASO\]) were assessed.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 60 Years
- **Sex:** FEMALE
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* be aged between 50 and 60 years.
* be postmenopausal (absence of menses \> 12 months).
* present a BMI greater than or equal to 30 kg/m2.
* be free of any special diets in the three months prior to the start of the intervention.
* have a sedentary lifestyle (exercise less than 2 h/week).

Exclusion Criteria:

* Suffering from any cardiovascular/renal/pulmonary/metabolic disease.
* Being under menopausal hormone therapy.
* Presenting any orthopedic limitations interfering the ability to perform the study intervention.
```

## Arms

- **Training group** (EXPERIMENTAL) — The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6- min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks.
- **Control group** (NO_INTERVENTION) — No training intervention was intended for the control group.

## Interventions

- **walking intervention** (BEHAVIORAL) — Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week.

## Primary Outcomes

- **serum creatinine** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — serum concentrations of creatinine (sCr) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
- **blood urea nitrogen** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — serum concentrations of blood urea nitrogen (BUN) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
- **serum uric acid** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — serum concentrations of uric acid (sUA) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
- **glomerular Filtration Rate** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — the glomerular Filtration Rate (GFR) has been computed using the Cockcroft formula, as follows: GFR (mL/min) = \[(140 - age) × weight ×0.85\]/(sCr× 72).
- **white blood cells count** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentration of white blood cells (WBC) count were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany)
- **neutrophils** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentration of neutrophils (NEU) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
- **lymphocytes** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentrations of lymphocytes (LYM) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
- **monocytes** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentration of monocytes (MON) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
- **eosinophils** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentrations of eosinophils (EOSI) ) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
- **basophils** _(time frame: At baseline and at week 11(after the ten weeks of the training intervention).)_ — blood concentration of basophils (BASO) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).

## Secondary Outcomes

- **Body composition** _(time frame: At baseline and after ten weeks of the training intervention.)_
- **6 min walking test** _(time frame: At baseline and after ten weeks of the training intervention.)_

## Locations (1)

- High Institute of Sports and Physical Education of Kef, Boulifa, Kef Governorate, Tunisia

## Recent Field Changes (last 30 days)

- `design.enrollmentCount` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.high institute of sports and physical education of kef|boulifa|kef governorate|tunisia` — added _(2026-05-12)_

---

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