---
title: Vertical Ridge Augmentation Using Computer-guided Sandwich Osteotomy Technique
nct_id: NCT07028606
overall_status: ACTIVE_NOT_RECRUITING
phase: PHASE1
sponsor: Al-Azhar University
study_type: INTERVENTIONAL
primary_condition: Alveolar Bone Resorption
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07028606.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07028606"
ct_last_update_post_date: 2025-06-19
last_seen_at: "2026-05-12T07:28:05.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Vertical Ridge Augmentation Using Computer-guided Sandwich Osteotomy Technique

**Official Title:** Effect of Arginine - Glycine - Aspartic Acid (RGD) Hydrogel on Vertical Ridge Augmentation Using Computer-guided Sandwich Osteotomy Technique, With Xenograft and Simultaneous Implant Placement

**NCT ID:** [NCT07028606](https://clinicaltrials.gov/study/NCT07028606)

## Key Facts

- **Status:** ACTIVE_NOT_RECRUITING
- **Phase:** PHASE1
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 12
- **Lead Sponsor:** Al-Azhar University
- **Conditions:** Alveolar Bone Resorption
- **Start Date:** 2024-05-09
- **Completion Date:** 2025-06-10
- **CT.gov Last Update:** 2025-06-19

## Brief Summary

Researcher will introduce the trial to patients and provide full explanation of its aim and benefits in Arabic language. Patients will then be able to have an informed discussion with the researcher. Researcher will obtain written consent from patients willing to participate in the trial

## Detailed Description

This protocol and the template informed consent form will be reviewed by the Ethics Committee of Scientific Research -Faculty of Oral and Dental Medicine- Al-Azhar University.

## Eligibility

- **Minimum age:** 30 Years
- **Maximum age:** 45 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion criteria

* Adults (age 30-45) with vertical ridge deficiency.
* Patients with maxillary vertical ridge deficiency 4-8mm according to Cologne Classification of Alveolar Ridge Defects (CCARD).
* Patients with good oral hygiene.
* Free from systemic diseases that may influence the outcome of the therapy.

Exclusion criteria

* Systemic conditions which are generally considered to be a contraindication to implant surgery which included but not limited to: osteoporosis, uncontrolled diabetes.
* Pregnant or lactating females
* Current or former smokers.
* Patient treated by immunosuppressive chemotherapy or radio therapy,
* Allergy to any material or medication used in the study.
```

## Arms

- **Sandwich technique with xenograft, collagen membrane and simultaneous implant placement** (PLACEBO_COMPARATOR) — (Control group) will receive computer-guided sandwich osteotomy technique with xenograft, collagen membrane and simultaneous implant placement.
- **Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement** (ACTIVE_COMPARATOR) — (Study group) will receive computer-guided sandwich osteotomy technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.

## Interventions

- **Sandwich technique with xenograft, collagen membrane and simultaneous implant placement.** (PROCEDURE) — All surgery will be in upper arch, for sandwich osteotomy technique, after local anesthesia, crestal incision with buccal intrasulcular incisions will be done extending at least one tooth mesial and distal to the implant associated site. Full thickness mucoperiosteal flaps will be reflected to allow access for implant, distraction osteogenesis, xenograft.

Osteotomy for implant will be carried out with advanced kit of roott\_system Switzerland brand, sandwich osteotomy technique will be carried out with three full thickness cuts using the tungsten carbide disc were performed in the form of two vertical cuts away from the neighboring teeth by 3 mm and one horizontal bony cut on the labial surface of alveolar ridge. Bone splitting chisels were used in sequential width (2 mm, 3 mm) and lightweight mallet to complete splitting of the bony segment, the surgical sites will be irrigated with sterile saline. Surgical flaps will be sutured to the pre-surgical level.
- **Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.** (BIOLOGICAL) — All surgery will be in upper arch, for sandwich osteotomy technique, after local anesthesia, crestal incision with buccal intrasulcular incisions will be done extending at least one tooth mesial and distal to the implant associated site. Full thickness mucoperiosteal flaps will be reflected to allow access for implant, distraction osteogenesis, xenograft with and with RGD.

Injectable RGD-bioconjugate Mussel Adhesive Proteins (RGD-MAPs) composite hydroxypropyl methylcellulose (HPMC) hydrogels . Previously we developed a novel type of injectable self-supported hydrogel (2 mg/ml of RGD-MAPs/HPMC) based porcine nano hydroxyapatite (MPH) for dental graft, which could good handling property, biodegradation or biocompatibility with the hydrogel disassembly and provided efficient cell adhesion activity and no inflammatory responses. Surgical flaps will be sutured to the pre-surgical level with 4-0 polyproline non resorbable suture utilizing a single interrupted suturing technique.

## Primary Outcomes

- **Effect of RGD on volumetric bone changes** _(time frame: Preoperative Cone beam computed tomography (CBCT) with minimal field of view will be taken for (implant treatment plan), immediately after surgery, at time of loading and 6 months after loading.)_ — Cone beam computed tomography with minimal field of view was taken immediately after surgery, immediately before loading (6 months) and 6 months after loading to evaluate volumetric changes.

## Locations (1)

- Al-Azhar University, Cairo, Boys, Cairo, Nasr City, Egypt

## Recent Field Changes (last 30 days)

- `outcomes.primary` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.al-azhar university, cairo, boys|cairo|nasr city|egypt` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07028606.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07028606*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*