---
title: "Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction"
nct_id: NCT07124494
overall_status: RECRUITING
phase: NA
sponsor: Konya City Hospital
study_type: INTERVENTIONAL
primary_condition: Total Knee Arthroplasty
countries: Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07124494.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07124494"
ct_last_update_post_date: 2025-08-28
last_seen_at: "2026-05-12T07:07:18.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction

**Official Title:** Evaluation of the Effects of Regional Anesthesia Methods Applied in Total Knee Arthroplasty on Joint Range of Motion in the Postoperative Period and Patient Satisfaction

**NCT ID:** [NCT07124494](https://clinicaltrials.gov/study/NCT07124494)

## Key Facts

- **Status:** RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 30
- **Lead Sponsor:** Konya City Hospital
- **Conditions:** Total Knee Arthroplasty, Postoperative Pain, Regional Anesthesia, Knee Range of Motion, Patient Satisfaction
- **Start Date:** 2025-08-05
- **Completion Date:** 2026-02-19
- **CT.gov Last Update:** 2025-08-28

## Brief Summary

This is a single-center, prospective, randomized controlled trial aiming to evaluate the effects of different regional anesthesia/analgesia techniques on postoperative knee range of motion (ROM) and patient satisfaction following total knee arthroplasty (TKA). Ninety patients undergoing elective TKA under spinal anesthesia will be randomly assigned to one of three groups: 1) spinal anesthesia with epidural catheter, 2) spinal anesthesia followed by adductor canal catheterization, and 3) spinal anesthesia with multimodal intravenous analgesia. The primary outcome is postoperative knee joint ROM measured on postoperative days 1, 2, and 3. Secondary outcomes include patient satisfaction, Oxford Knee Score, postoperative opioid consumption, and VAS scores. The study is conducted at Konya City Hospital and will be completed over a 6-month period.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
* Minimum Age: 18 Years
* Maximum Age: None
* Sex: All
* Gender Based: No
* Accepts Healthy Volunteers: No
* Inclusion Criteria:

  * Scheduled for primary total knee arthroplasty
  * Age ≥ 18 years
  * American Society of Anesthesiologists (ASA) physical status I-III
  * Accepting neuraxial anesthesia
* Exclusion Criteria:

  * Skin infection at the planned injection site
  * Sepsis
  * Coagulopathy
  * Refusal of neuraxial anesthesia
  * Severe hypovolemia
  * Demyelinating central nervous system disease
  * Age under 18 years
  * Illiterate in Turkish
  * Non-cooperative patients
  * Known allergy or hypersensitivity to bupivacaine
```

## Arms

- **Combined Spinal-Epidural Anesthesia** (ACTIVE_COMPARATOR) — Postoperative analgesia will be provided via epidural catheter with programmed infusion of bupivacaine .
- **Adductor Canal Block** (ACTIVE_COMPARATOR) — Ultrasound-guided adductor canal catheter placement and continuous infusion of bupivacaine .
- **Multimodal Intravenous Analgesia** (SHAM_COMPARATOR) — Continuous intravenous tramadol infusion with rescue analgesia as required.

## Interventions

- **Regional anethesia** (PROCEDURE) — This single-center, prospective, randomized controlled trial aims to compare the effects of three different postoperative analgesia techniques following spinal anesthesia in patients undergoing total knee arthroplasty (TKA). The study will assess the impact of combined spinal-epidural anesthesia, adductor canal block, and multimodal intravenous analgesia on postoperative knee range of motion (ROM). Secondary outcomes include patient satisfaction, opioid consumption, Oxford Knee Score (OKS), activity levels, and visual analog scale (VAS) pain scores.

## Primary Outcomes

- **Postoperative Knee Range of Motion (ROM)** _(time frame: Postoperative day 1, day 3, day 7, and day 90 after surgery.)_ — Knee joint flexion and extension range of motion will be measured using a standard goniometer by a blinded assessor. Measurements will be performed with the patient in a supine position, ensuring standardized positioning for all participants.

## Secondary Outcomes

- **Total Opioid Consumption** _(time frame: From the end of surgery to 72 hours postoperatively.)_
- **Oxford Knee Score (OKS)** _(time frame: Preoperatively (baseline) and postoperative day 90.)_
- **Visual Analog Scale (VAS) Pain Score** _(time frame: Postoperative day 1, day 3, and day 7 after surgery.)_
- **Incidence of Adverse Events Related to Anesthesia or Analgesia** _(time frame: Intraoperative period and up to 90 days postoperatively.)_
- **Patient Satisfaction Score** _(time frame: Postoperative day 3 and day 90 after surgery.)_

## Locations (1)

- Yasin Tire, Konya, Meram, Turkey (Türkiye) — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.yasin tire|konya|meram|turkey (türkiye)` — added _(2026-05-12)_

---

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