---
title: The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
nct_id: NCT07146399
overall_status: COMPLETED
phase: NA
sponsor: Ziyue Ou
study_type: INTERVENTIONAL
primary_condition: Ischemic Preconditioning
countries: China
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07146399.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07146399"
ct_last_update_post_date: 2025-08-28
last_seen_at: "2026-05-12T06:36:54.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function

**Official Title:** Ischemic Preconditioning Enhances Autonomic Nervous System Modulation During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study

**NCT ID:** [NCT07146399](https://clinicaltrials.gov/study/NCT07146399)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 15
- **Lead Sponsor:** Ziyue Ou
- **Collaborators:** Guangzhou Sport University
- **Conditions:** Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
- **Start Date:** 2023-12-31
- **Completion Date:** 2024-02-07
- **CT.gov Last Update:** 2025-08-28

## Brief Summary

Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 22 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
* adult males aged 18 years or older;
* regular participation in specialized Taekwondo training for the past three months.
* All the subjects were from the same team.

Exclusion Criteria:

* consumption of alcohol or caffeine within 24 hours prior to the experiment;
* engagement in strenuous physical activity within 24 hours before the experiment;
* presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
* use of creatine supplements
```

## Arms

- **IPC Trial** (EXPERIMENTAL) — 220 mmHg
- **SHAM Trial** (PLACEBO_COMPARATOR) — 20 mmHg

## Interventions

- **Ischemic Preconditioning** (PROCEDURE) — Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) \*4. 220 mmHg
- **Sham (No Treatment)** (PROCEDURE) — Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) \*4. 20 mmHg

## Primary Outcomes

- **Taekwondo-specific sports performance test.** _(time frame: Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti)_ — The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.
- **Heart rate variability** _(time frame: The measurement time points were as follows: heart rate variability was assessed in the resting state upon participants' arrival at the testing site, after a warm-up, and following the sport-specific performance test.)_ — Used to measure the autonomic nervous function of taekwondo athletes.
- **Heart rate recovery** _(time frame: The measurement time points were established as follows: heart rate recovery was assessed for 1 minute during the intervals of each test group. Additionally, heart rate recovery was recorded at both 1 minute and 5 minutes following the completion of thre)_ — Used to measure the autonomic nervous function of taekwondo athletes.
- **Blood lactate** _(time frame: Blood lactate measurements were taken at several key time points during the study: upon participants' arrival at the test site while they were in a quiet state; at the 3rd minute following the conclusion of the intervention; prior to the commencement of)_ — Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes.

## Locations (1)

- Guangzhou Sport University, Guangzhou, Guangdong, China

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.guangzhou sport university|guangzhou|guangdong|china` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT07146399*  
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