---
title: AST-120 (Kremezin®) for the Renal Protection and Attenuation of Decline in Acute Kidney Disease
nct_id: NCT07182422
overall_status: RECRUITING
phase: PHASE4
sponsor: Chang Gung Memorial Hospital
study_type: INTERVENTIONAL
primary_condition: Acute Kidney Disease
countries: Taiwan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07182422.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07182422"
ct_last_update_post_date: 2025-09-19
last_seen_at: "2026-05-12T07:08:57.014Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# AST-120 (Kremezin®) for the Renal Protection and Attenuation of Decline in Acute Kidney Disease

**Official Title:** Impact of Kremezin on Renal Recovery and Uremic Toxin Levels in Patients With Acute Kidney Disease

**NCT ID:** [NCT07182422](https://clinicaltrials.gov/study/NCT07182422)

## Key Facts

- **Status:** RECRUITING
- **Phase:** PHASE4
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 100
- **Lead Sponsor:** Chang Gung Memorial Hospital
- **Collaborators:** Conmed Pharmaceutical & Bio-Medical Corporation
- **Conditions:** Acute Kidney Disease, Acute Kidney Injury (AKI)
- **Start Date:** 2025-09-15
- **Completion Date:** 2027-03-13
- **CT.gov Last Update:** 2025-09-19

## Brief Summary

The primary goal of this clinical trial is to evaluate the efficacy of AST-120 (Kremezin®) in combination with standard care in reducing the levels of protein-bound uremic toxins (PBUTs), specifically indoxyl sulfate (IS) and p-cresyl sulfate (p-CS), in patients with acute kidney disease (AKD). The trial aims to assess whether AST-120 can prevent further renal deterioration and slow the progression from AKD to chronic kidney disease (CKD) by mitigating the accumulation of PBUTs. Additionally, the study will investigate the potential of AST-120 to reduce the risk of CKD-associated complications, including cardiovascular disease, by reducing PBUT levels in AKD patients.

## Detailed Description

Study Procedures：

1. Total Number of Subjects The total number of subjects planned for enrollment is 100.

The study will include two groups:

1. Experimental Group: 50 patients receiving AST-120 (6g/day) in combination with standard post-AKD care.
2. Control Group: 50 patients receiving only standard post-AKD care. The sample size is determined based on the statistical power needed to detect a significant difference in the primary endpoint (percentage changes in IS levels), with consideration for potential dropout rates. The evaluable number is estimated to be close to 90, allowing for a 10% dropout rate, making the enrolled number 100.

2\. Interventions, Procedures, and Tests for Each Group

Subjects will undergo the following interventions, procedures, and tests according to the schedule:

1. Baseline (Day 0):

   \- Demographic data collection.
   * Blood tests for serum creatinine, eGFR, IS, p-CS, and urinary albumin-to-creatinine ratio (UACR).
   * Randomization into experimental or control groups.
2. Treatment Period (Day 1-14):

   * Experimental Group: Receive AST-120 (6g/day, divided into three doses per day).
   * Control Group: Standard post-AKD care only.
   * Both groups will undergo regular clinical assessments and adverse event monitoring.
3. Day 14:

   * Blood tests for IS, p-CS, serum creatinine, eGFR, and UACR.
   * Follow-up (Day 90 and Day 180):
   * Assess eGFR, serum creatinine, UACR.
   * Monitor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE).

     3\. Trial Procedure Timeline

The trial procedure follows this timeline:

1. Day 0: Baseline measurements and randomization.
2. Day 1-14: Treatment phase (AST-120 administration or standard care).
3. Day 14: Blood tests and assessment of treatment efficacy.
4. Day 90 and Day 180: Follow-up visits for MAKE and MACE assessments, and blood tests for kidney function.

4\. Specimen Collection and Processing

1. Specimen: Blood samples will be collected on Day 0 (baseline), Day 14 (end of treatment), Day 90, and Day 180 (follow-up).
2. Transport and Storage: Specimens will be transported to the laboratory within the hospital for immediate processing. They will be stored in a temperature-controlled facility if needed.
3. Processing: Blood samples will undergo centrifugation for serum separation. Serum will be used for measuring IS, p-CS, serum creatinine, and other biomarkers.
4. Analysis: The following tests will be performed:

   * IS and p-CS levels.
   * Serum creatinine and eGFR.
   * UACR.

     5\. Clinical Data Collection and Questionnaires

Clinical data collected will include:

1. Demographic data (age, sex, medical history).
2. Lab results for IS, p-CS, creatinine, eGFR, UACR. No specific questionnaires will be used for this study.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion/Exclusion Criteria： Inclusion criteria

1. Age between 18 and 80 years.
2. Diagnosis of acute kidney disease (AKD) during hospitalization, with AKD stage 2 or 3 according to the KDIGO-AKD criteria, defined by an increase in serum creatinine to 2 times or more from baseline within 7 to 90 days.
3. Post-discharge estimated glomerular filtration rate (eGFR) between 30 and 60 ml/min/1.73m², calculated using the MDRD equation.
4. Hospitalization duration not exceeding 1 month.

Exclusion criteria

1. Patients with cancer or hematological malignancies.
2. Patients with AKD etiologies that cannot be managed in an outpatient setting (e.g., diabetic foot, obstructive uropathy with sepsis, cirrhosis).

1\. Patients presenting any of the following conditions, considered as excessively vulnerable populations or other conditions:

* Bedridden.
* Requiring nasogastric tube feeding.
* Long-term use of oxygen therapy.
* Use of urinary catheters.

Patients unsuitable for AST-120 treatment, including:

* Patients with severe constipation (defined as requiring the daily use of more than one laxative).
* Patients with abnormal liver function (defined as ALT levels greater than 5 times the upper limit or total bilirubin \> 2mg/dL).
* Patients with a history of peptic ulcers within the last month.
* Pregnant women.
* Patients allergic to the study drug.
```

## Arms

- **Control** (NO_INTERVENTION) — Control (Standard Care Only) Intervention: Standard post-AKD care No AST-120
- **Experimental (AST-120 + Standard Care)** (EXPERIMENTAL) — Intervention: AST-120 (Kremezin®) Dosage: 6 g/day (2 g TID, oral) Duration: 14 days Background treatment: Standard post-AKD care

## Interventions

- **AST-120 (Kremezin®)** (DRUG) — AST-120 (Kremezin®) Dosage: 6 g/day (2 g TID, oral) Duration: 14 days Background treatment: Standard post-AKD care

## Primary Outcomes

- **Change in serum indoxyl sulfate (IS) concentration** _(time frame: Day 0, Day 14, Day 90, Day 180)_ — Change in serum indoxyl sulfate (IS) concentration

Time Frame: Baseline to Day 180

Description: Evaluate reduction in IS levels after AST-120 treatment compared to control.

## Secondary Outcomes

- **Change in serum p-cresyl sulfate (p-CS) concentration** _(time frame: Day 0, Day 14, Day 90, Day 180)_
- **Change in estimated glomerular filtration rate (eGFR)** _(time frame: Day 0, Day 14, Day 90, Day 180)_
- **Change in urine albumin/creatinine ratio (UACR)** _(time frame: Day 0, Day 14, Day 90, Day 180)_
- **Change in urine total protein/creatinine ratio (UPCR)** _(time frame: Day 0, Day 14, Day 90, Day 180)_

## Locations (1)

- Chang Gung Memorial Hospital, Taoyuan, Taiwan, Taoyuan, Taiwan — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.chang gung memorial hospital, taoyuan, taiwan|taoyuan||taiwan` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT07182422*  
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