---
title: Gingival Cleft Development at Two Time Points of Canine Retraction
nct_id: NCT07210762
overall_status: RECRUITING
phase: NA
sponsor: Bahria University
study_type: INTERVENTIONAL
primary_condition: Gingival Cleft
countries: Pakistan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07210762.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07210762"
ct_last_update_post_date: 2025-10-07
last_seen_at: "2026-05-12T06:14:30.685Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Gingival Cleft Development at Two Time Points of Canine Retraction

**Official Title:** Gingival Cleft Development at Two Time Points of Canine Retraction: a Split-mouth Randomized Controlled Trial

**NCT ID:** [NCT07210762](https://clinicaltrials.gov/study/NCT07210762)

## Key Facts

- **Status:** RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 19
- **Lead Sponsor:** Bahria University
- **Conditions:** Gingival Cleft, Orthodontic Space Closure
- **Start Date:** 2025-10-15
- **Completion Date:** 2026-07-19
- **CT.gov Last Update:** 2025-10-07

## Brief Summary

The goal of this split-mouth randomized controlled trial is to assess whether the timing of extraction space closure-early vs. delayed initiation-affects the incidence of gingival cleft development in orthodontic patients. The main question it aims to answer is:

Does the incidence of gingival cleft development get influenced by the specific time point at which orthodontic space closure is initiated following extraction?

Quadrants will be assigned to the early movement group and the other to the delayed movement group and extractions will be performed accordingly. These will be assessed for the effect on development of gingival cleft development.

## Eligibility

- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

1. Extraction advised of both first premolars from either maxilla, mandible or both.
2. All permanent dentition present apart from third molars.

Exclusion Criteria:

1. Severe crowding
2. Smokers
3. Patients with systemic diseases that could interfere with bone remodeling.
4. Patients with periodontitis or poor periodontal health.
5. Patients who have previously undergone periodontal surgery in the area of interest.
6. Patients with other oral health conditions that could complicate the treatment or healing process.
```

## Arms

- **Early movement group** (EXPERIMENTAL) — Canine retraction will be started 1 week after extraction
- **Delayed Movement** (EXPERIMENTAL) — Canine retraction will be started 8 weeks after extraction

## Interventions

- **Early space closure** (OTHER) — Space closure will be started 1 week after extraction
- **Delayed space closure** (OTHER) — Space closure will be started 8 weeks after extraction

## Primary Outcomes

- **presence of gingival clefts after space closure initiation** _(time frame: start of canine retraction to its completion (approximately 6 months))_ — The primary outcome will be the presence of gingival clefts, which will be measured at 3 months and 6 months after space closure initiation

## Secondary Outcomes

- **craniofacial growth pattern** _(time frame: craniofacial growth pattern will be measured at baseline)_
- **gingival biotype** _(time frame: At baseline (immediately prior to tooth extraction))_
- **buccal bone dehiscence** _(time frame: Immediately post extraction)_
- **canine bulbosity** _(time frame: will be measured at baseline)_

## Locations (1)

- Bahria University of Health Sciences Karachi, Karachi, Sindh, Pakistan — _RECRUITING_

## Recent Field Changes (last 30 days)

- `results.hasResults` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `locations.bahria university of health sciences karachi|karachi|sindh|pakistan` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07210762.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07210762*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*