---
title: Hand Cooling With Ice Packs in Healthy Young Men
nct_id: NCT07254182
overall_status: COMPLETED
phase: NA
sponsor: Poznan University of Physical Education
study_type: INTERVENTIONAL
primary_condition: Cold Exposure
countries: Poland
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07254182.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07254182"
ct_last_update_post_date: 2025-11-28
last_seen_at: "2026-05-12T06:56:26.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Hand Cooling With Ice Packs in Healthy Young Men

**Official Title:** Effects of Ice-Pack Application on Hand Skin Temperature and Subjective Thermal Sensation and Comfort in Healthy Young Men: A Randomized, Parallel-Group Controlled Trial

**NCT ID:** [NCT07254182](https://clinicaltrials.gov/study/NCT07254182)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 39
- **Lead Sponsor:** Poznan University of Physical Education
- **Conditions:** Cold Exposure, Body Temperature Regulation, Thermal Comfort Perception
- **Start Date:** 2018-04-12
- **Completion Date:** 2018-07-11
- **CT.gov Last Update:** 2025-11-28

## Brief Summary

This randomized, parallel-group study looked at how a standard 15-minute ice pack applied to the back of the hand affects skin temperature and how cold and comfortable the hand feels, compared with a room-temperature water pack. Healthy young men were randomly assigned to one of the two groups during a single laboratory visit. Skin temperature was measured before, during, and after the application, and participants rated their thermal sensation (how cold/warm they felt) and overall comfort.

The main outcome was the change in hand skin temperature right after the 15-minute application. Additional outcomes included comfort and cold-feeling ratings and how quickly skin temperature returned toward baseline during recovery. This was a minimal-risk study; expected short-term effects included temporary cold, numbness, redness, or mild discomfort. No medicines or invasive procedures were used.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 30 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Healthy male volunteers (university student population).
* Good general health with no history of neck or upper-quadrant pain.
* Able to provide written informed consent.
* Willing to comply with pre-visit restrictions on the study day (abstain from tobacco, coffee, alcohol; no hand ointments for 24 h; wash/degrease hands ≥1 h before testing; refrain from vigorous exercise/physical treatments for 24 h).

Exclusion Criteria:

* Diabetes
* Thyroid or other endocrine dysfunction
* Significant spinal pain
* Generalised neurological or rheumatological disorders
* Regular use of pain medications or psychotropic medications
```

## Arms

- **Ice Pack (Localized Cryotherapy)** (EXPERIMENTAL) — Single 15-minute application of a reusable plastic ice pack (Mueller; Ø 22.86 cm, 946 mL). The pack was filled with 400 g of pre-portioned cylindrical ice and placed on the dorsal side of the dominant hand, \~1 cm proximal to the wrist-joint line, fully covering the fingers. Participants were supine with the hand slightly elevated; ambient conditions were controlled at ≈22.5 ± 1.0 °C and 55.3 ± 6.5% relative humidity (RH).Contact was maintained throughout the application; thermal sensation/comfort and pain were recorded during the 7th and 15th minutes.
- **Thermoneutral Water Pack (Control)** (ACTIVE_COMPARATOR) — Identical 15-minute application using the same Mueller pack filled with thermoneutral water (within ±0.5 °C of limb skin temperature), mass-matched to 400 g. Placement, posture, and ambient conditions mirrored the experimental arm: pack on the dorsal side of the dominant hand, \~1 cm proximal to the wrist-joint line, fully covering the fingers; participants supine, hand slightly elevated; sensation/comfort and pain recorded at minutes 7 and 15.

## Interventions

- **Ice Pack (Localized Cryotherapy)** (OTHER) — Single 15-minute application of a reusable plastic Mueller ice bag (Ø 22.86 cm, 946 mL). The bag was filled with 400 g pre-portioned cylindrical ice and placed on the dorsal side of the dominant hand, \~1 cm proximal to the wrist-joint line, fully covering the fingers. Participants were supine with the treated hand slightly elevated; ambient temperature and humidity were controlled (≈22.5 ± 1.0 °C; 55.3 ± 6.5% RH). Subjective thermal sensation/comfort (and pain) were recorded at minutes 7 and 15 during application. Arm: Experimental - Ice Pack
- **Thermoneutral Water Pack (Control)** (OTHER) — Identical 15-minute application using the same Mueller bag, filled with thermoneutral water (within ±0.5 °C of limb skin temperature), mass-matched to 400 g. Placement, posture, room conditions, and timing of subjective assessments (minutes 7 and 15) mirrored the experimental arm: bag on the dorsal side of the dominant hand, \~1 cm proximal to the wrist-joint line, fully covering the fingers; participants supine with the hand slightly elevated. Arm: Active Comparator - Thermoneutral Water Pack.

## Primary Outcomes

- **Minimum dorsal-hand skin temperature during rewarming (IV-X), by infrared thermography** _(time frame: From immediately after pack removal (0 minutes; time point IV) to 30 minutes after pack removal (time point X).)_ — Region-of-interest (ROI) mean skin temperature (Tsk; °C) on the dorsal hand measured with infrared thermography (IRT; FLIR SC640). The primary estimand is the between-group mean difference (Ice - Thermoneutral) in the nadir (minimum) across rewarming time points IV-X, with 95% confidence intervals (CI). Lower values indicate greater cooling.

## Secondary Outcomes

- **IRT-RT temperature offset at matched time points I-X** _(time frame: Baseline (after acclimatisation) and at 0, 5, 10, 15, 20, 25, and 30 minutes after ice-pack removal.)_
- **Change in Mechanical Detection Threshold (MDT) from baseline to immediately post (I → IV)** _(time frame: Baseline (after acclimatisation; time point I) and 0 minutes after ice-pack removal (time point IV).)_
- **Change in Vibration Detection Threshold (VDT) from baseline to immediately post (I → IV)** _(time frame: Baseline (after acclimatisation; time point I) and 0 minutes after ice-pack removal (time point IV).)_
- **Thermal Sensation (TSS) during cooling and immediately post** _(time frame: Baseline (after acclimatisation; time point I), 7 minutes after ice-pack application (time point II), 15 minutes after ice-pack application (time point III), and 0 minutes after ice-pack removal (time point IV).)_
- **Thermal Comfort (CS) during cooling and immediately post** _(time frame: Baseline (after acclimatisation; time point I), 7 minutes after ice-pack application (time point II), 15 minutes after ice-pack application (time point III), and 0 minutes after ice-pack removal (time point IV).)_
- **Pain Intensity (Visual Analogue Scale; VAS) during cooling and immediately after ice-pack removal** _(time frame: Baseline (after acclimatisation; time point I), 7 minutes after ice-pack application (time point II), 15 minutes after ice-pack application (time point III), and 0 minutes after ice-pack removal (time point IV).)_

## Locations (1)

- Poznan University of Physical Education, Department of Physical Therapy and Sports Recovery, Poznan, Poland

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.poznan university of physical education, department of physical therapy and sports recovery|poznan||poland` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07254182.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07254182*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*