---
title: A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)
nct_id: NCT07341984
overall_status: RECRUITING
phase: NA
sponsor: Charlotte Vogt
study_type: INTERVENTIONAL
primary_condition: Amyotrophic Lateral Sclerosis
countries: Switzerland
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07341984.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07341984"
ct_last_update_post_date: 2026-01-15
last_seen_at: "2026-05-12T07:29:11.213Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

**Official Title:** Individualized Physiotherapy Addressing Patient-Specific Deficits in Amyotrophic Lateral Sclerosis Compared to Usual Care Physiotherapy: A Prospective, Pseudorandomized, Controlled, Interventional Study

**NCT ID:** [NCT07341984](https://clinicaltrials.gov/study/NCT07341984)

## Key Facts

- **Status:** RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 38
- **Lead Sponsor:** Charlotte Vogt
- **Conditions:** Amyotrophic Lateral Sclerosis
- **Start Date:** 2025-12-16
- **Completion Date:** 2028-12-15
- **CT.gov Last Update:** 2026-01-15

## Brief Summary

This study investigates whether an individualized physiotherapy program, tailored to each patient's specific motor deficits, can better support physical function compared with usual care physiotherapy in people with ALS.

The individualized program is guided by diagnostic assessments using a robotic leg press system, which helps identify strengths and weaknesses in muscle function and movement control.

Participants will receive either individualized physiotherapy or standard physiotherapy and will be followed for 12 months. The aim of the study is to improve physiotherapy strategies for people with ALS in a safe and patient-centered manner.

## Eligibility

- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* diagnosis of clinically probable, probable laboratory-supported, or definite ALS (revised El Escorial criteria) or upper motor neuron only (OPM classification \[onset, propagation, motoneuron involvement\])
* age ≥18 years; ability to understand study information and provide written informed consent
* Willingness and ability to perform individualized exercise according to the study protocol (approximately three to five sessions of 30 minutes per week) for the duration of the intervention period
* Individuals of all sexes and gender identities are eligible for inclusion

Exclusion Criteria:

* pregnancy, tracheostomy, continuous assisted ventilation, or other significant non-ALS pulmonary disease
* other neurodegenerative or neuromuscular conditions that may confound assessments
* concomitant life-threatening disease or impairment interfering with functional assessment
```

## Arms

- **Individualized Physiotherapy Group** (EXPERIMENTAL) — This group receives an individualized physiotherapy program tailored to patient-specific functional deficits. Two thrids of participants are allocated to the intervention group.
- **Usual Care Physiotherapy Group** (ACTIVE_COMPARATOR) — This group continues to receive usual care physiotherapy in accordance with standard clinical practice. One third of participants are allocated to the control group.

## Interventions

- **Individualized Physiotherapy** (OTHER) — see above

## Primary Outcomes

- **Climbing stairs (ALSFRS-R [amyotrophic lateral sclerosis functional rating scale - revised] - item 9: score range 0 to 4 with 4 indicating normal function)** _(time frame: 6 months)_ — funcitonal

## Locations (1)

- ALS Clinic, Sankt Gallen, Switzerland — _RECRUITING_

## Recent Field Changes (last 30 days)

- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `locations.als clinic|sankt gallen||switzerland` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07341984.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07341984*  
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