---
title: Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
nct_id: NCT07420426
overall_status: RECRUITING
phase: NA
sponsor: The University of Hong Kong
study_type: INTERVENTIONAL
primary_condition: Mild Cognitive Impairment (MCI)
countries: Hong Kong
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07420426.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07420426"
ct_last_update_post_date: 2026-02-23
last_seen_at: "2026-05-12T06:45:33.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment

**Official Title:** Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment: a Mixed Methods Study

**NCT ID:** [NCT07420426](https://clinicaltrials.gov/study/NCT07420426)

## Key Facts

- **Status:** RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 160
- **Lead Sponsor:** The University of Hong Kong
- **Conditions:** Mild Cognitive Impairment (MCI)
- **Start Date:** 2025-12-08
- **Completion Date:** 2026-10-02
- **CT.gov Last Update:** 2026-02-23

## Brief Summary

This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment, and to investigate the feasibility and effectiveness of the intervention.

## Detailed Description

1. Message contents:

   The message content library will consist of two parts: 1. brief mild cognitive impairment messages (optional), and 2. acceptance and commitment therapy messages (mandatory).
2. Message delivery

   * Regular messages: The messages in the two parts will be sent regularly to each participant. As personalisation is a core process subject to behavioural changes, the content, frequency, and timing of the messages will be determined based on participants' preferences. To save labour and increase efficiency, the investigators will develop a message 'scheduler' program. The investigators will pre-set the message scheduler, which will then automatically send out content to the participants according to their preferences. The development of the program is highly useful particularly in cases which participants prefer to receive messages during non-office hours.
   * Real-time support messages (chat-type): Chat-based support will be given to the participants as an extension of the regular messages. However, the participants will be informed beforehand that the RA will only play a supportive role and will not provide formal care. The number of the chat messages will not be limited, but the real-time support messages will only be provided during working hours (i.e., 9am-10pm) on weekdays to limit the RA's workload.

Control Group:

The control group will receive instant messages about mental health management from GovHK website (https://www.gov.hk/en/residents/health/mental/), which is open to the public.

## Eligibility

- **Minimum age:** 50 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Community-dwelling adults aged ≥ 50 years
* HK-MoCA score ranged from 18 to 22
* MBI-C ≥7
* SCD-9 ≥3
* IADL \<18
* Able to read and communicate in Chinese
* Able to use the text or voice messaging function on a smartphone

Exclusion Criteria:

* Clinical diagnosis of dementia
* Clinical diagnosis of psychiatric disease
* Currently participating in any type of psychological or behavioural intervention for NPSs
* Currently taking psychiatric medication
* Currently receiving acute care or post-acute hospitalization care
```

## Arms

- **Intervention group** (EXPERIMENTAL) — Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., our multidisciplinary team - including a neurologist, nurses, clinical psychologists and gerontologists - will develop an ACT message content library and protocol for IM delivery (i.e. EMI).
- **Control group** (ACTIVE_COMPARATOR) — The control group will receive instant messages about general mental health management from the HKSAR Government website, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.

## Interventions

- **automated instant message-guided neuropsychiatric symptoms management** (BEHAVIORAL) — Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., we will develop a message content library and protocol for EMI delivery.
- **general mental health management** (BEHAVIORAL) — Participants in control group will receive the messages for 8 weeks.The control group will receive instant messages about general mental health management from the HKSAR Government website, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.

## Primary Outcomes

- **MBI-C scores** _(time frame: at 2nd and 6th months)_ — The primary outcome will be MBI-C scores to assess NPSs. A higher MBI-C scores will indicate a higher level of neuropsychiatric symptoms.

## Secondary Outcomes

- **Depressive symptoms (PHQ-9)** _(time frame: at 2nd and 6th months)_
- **Anxiety symptoms (GAD-7)** _(time frame: at 2nd and 6th months)_
- **Quality of life (EuroQol 5-dimension 5-level questionnaire [EQ-5D-5L])** _(time frame: at 2nd and 6th months)_
- **Cognitive functions (HK-MoCA)** _(time frame: at 2nd and 6th months)_
- **Acceptance of negative emotions and valued-based actions (AAQ-II)** _(time frame: at 2nd and 6th months)_
- **Subjective Cognitive Decline scale (SCD-9)** _(time frame: at 2nd and 6th months)_

## Locations (1)

- The University of Hong Kong, Hong Kong, Hong Kong — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.the university of hong kong|hong kong||hong kong` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07420426.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07420426*  
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