---
title: Hidden Link Between Meatal Stenosis and Primary Nocturnal Enuresis in Children
nct_id: NCT07424651
overall_status: COMPLETED
sponsor: New Valley University
study_type: OBSERVATIONAL
primary_condition: Meatal Stenosis
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07424651.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07424651"
ct_last_update_post_date: 2026-02-20
last_seen_at: "2026-05-12T07:09:20.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Hidden Link Between Meatal Stenosis and Primary Nocturnal Enuresis in Children

**Official Title:** Investigating the Hidden Link Between Meatal Stenosis and Primary Nocturnal Enuresis in Children

**NCT ID:** [NCT07424651](https://clinicaltrials.gov/study/NCT07424651)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 400
- **Lead Sponsor:** New Valley University
- **Conditions:** Meatal Stenosis, Primary Nocturnal Enuresis, Children
- **Start Date:** 2021-01-31
- **Completion Date:** 2025-03-10
- **CT.gov Last Update:** 2026-02-20

## Brief Summary

This study aimed to investigate the association between meatal stenosis and primary nocturnal enuresis severity, and evaluated therapeutic outcomes following surgical correction.

## Detailed Description

Primary nocturnal enuresis (PNE) is a prevalent pediatric condition characterized by involuntary urination during sleep in children aged five years or older who have never achieved consistent nighttime dryness. The prevalence of PNE decreases with age, affecting approximately 15% of five-year-old and decreasing to 1-2% by adolescence.

Meatal stenosis, defined as the pathological narrowing of the urethral meatus, is an underexplored potential factor. This condition is known to cause obstructed urinary flow, incomplete bladder emptying, and increased bladder pressure, all of which may contribute to enuresis.

The incidence of meatal stenosis is higher in circumcised males but can also occur in uncircumcised males and females due to inflammation, trauma, or infection

## Eligibility

- **Minimum age:** 7 Years
- **Maximum age:** 12 Years
- **Sex:** MALE
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Male children aged 7-12 years.
* Diagnosed with primary nocturnal enuresis.
* Evaluated and treated at the study center between January 2021 and December 2024.
* Confirmed diagnosis of meatal stenosis based on clinical examination and uroflowmetry when indicated.
* Patients who underwent meatoplasty and completed the prescribed follow-up period.

Exclusion Criteria:

* Secondary enuresis (previously dry for ≥ 6 months before recurrence of bedwetting).
* Known neurological disorders (e.g., spina bifida, cerebral palsy) or developmental delays.
* Structural anomalies of the urinary tract other than meatal stenosis (e.g., posterior urethral valves, vesicoureteral reflux).
* Children who did not complete the follow-up or had incomplete clinical records.
```

## Arms

- **Study group** — Patients who underwent meatoplasty.

## Interventions

- **Meatoplasty Primary nocturnal enuresis.** (PROCEDURE) — Patients diagnosed with primary nocturnal enuresis.

## Primary Outcomes

- **Association between Meatal Stenosis and primary nocturnal enuresis** _(time frame: 3 years from collecting the data from the database)_ — Association between Meatal Stenosis and primary nocturnal enuresis was assessed to determine whether there is a significant relationship between the presence of meatal stenosis and the occurrence of primary nocturnal enuresis in male children aged 7-12 years.

## Secondary Outcomes

- **Resolution of primary nocturnal enuresis post-meatoplasty** _(time frame: 3 years from collecting the data from the database)_
- **Need for Revision Meatoplasty** _(time frame: 3 years from collecting the data from the database)_
- **Prevalence of Meatal Stenosis in primary nocturnal enuresis patients** _(time frame: 3 years from collecting the data from the database)_
- **Incidence of complications** _(time frame: 3 years from collecting the data from the database)_

## Locations (1)

- New Valley University, New Valley, Cairo Governorate, Egypt

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.new valley university|new valley|cairo governorate|egypt` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07424651.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07424651*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*