---
title: BPTB Versus Hamstring Autografts in ACL Reconstruction Among Professional Athletes
nct_id: NCT07573293
overall_status: COMPLETED
phase: NA
sponsor: Cairo University
study_type: INTERVENTIONAL
primary_condition: Anterior Cruciate Ligament Injury
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07573293.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07573293"
ct_last_update_post_date: 2026-05-07
last_seen_at: "2026-05-12T07:26:44.514Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# BPTB Versus Hamstring Autografts in ACL Reconstruction Among Professional Athletes

**Official Title:** Bone-Patellar Tendon-Bone Versus Hamstring Tendon Autografts in ACL Reconstruction Among Professional Athletes: A Prospective Randomized Controlled Study With Mid-term Follow-up

**NCT ID:** [NCT07573293](https://clinicaltrials.gov/study/NCT07573293)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 65
- **Lead Sponsor:** Cairo University
- **Collaborators:** Kasr Al-Ainy Hospitals
- **Conditions:** Anterior Cruciate Ligament Injury
- **Start Date:** 2018-02-01
- **Completion Date:** 2025-06-30
- **CT.gov Last Update:** 2026-05-07

## Brief Summary

This prospective randomized controlled study compares outcomes of ACL reconstruction using bone-patellar tendon-bone (BPTB) versus hamstring tendon (HT) autografts in professional athletes.

The primary outcome is isokinetic muscle strength assessment. Secondary outcomes include IKDC score, return to athletic activity, and complication rates. Patients are followed for five years.

## Detailed Description

This randomized controlled trial evaluates BPTB versus HT autografts in professional athletes undergoing ACL reconstruction. Patients with isolated ACL rupture were randomly assigned to either graft.

All procedures and rehabilitation protocols were standardized. The primary outcome was isokinetic assessment of quadriceps and hamstring strength using a dynamometer. Secondary outcomes included IKDC score, return to sport, and complications.

Patients were followed for five years to assess functional recovery and long-term outcomes.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 35 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Professional athletes actively engaged in competitive sports
* Age between 18 and 35 years
* Primary isolated anterior cruciate ligament (ACL) rupture confirmed clinically and by MRI
* Indicated for arthroscopic ACL reconstruction
* Willingness to participate and provide informed consent

Exclusion Criteria:

* Multiligamentous knee injuries
* Previous ACL reconstruction on the affected knee
* Lower limb malalignment
* Advanced chondral lesions requiring additional surgical procedures
* Associated fractures around the knee
* Inability to comply with follow-up protocol
```

## Arms

- **BPTB Group** (EXPERIMENTAL) — Participants undergoing ACL reconstruction using bone-patellar tendon-bone (BPTB) autograft.
- **Hamstring Group** (ACTIVE_COMPARATOR) — Participants undergoing ACL reconstruction using hamstring tendon autograft (semitendinosus and gracilis).

## Interventions

- **BPTB ACL Reconstruction** (PROCEDURE) — Arthroscopic anterior cruciate ligament reconstruction using bone-patellar tendon-bone autograft with interference screw fixation.
- **Hamstring ACL Reconstruction** (PROCEDURE) — Arthroscopic anterior cruciate ligament reconstruction using semitendinosus and gracilis tendon autograft with appropriate fixation technique.

## Primary Outcomes

- **Isokinetic Quadriceps and Hamstring Muscle Strength** _(time frame: 12 months postoperatively)_ — Isokinetic dynamometric assessment of quadriceps and hamstring muscle strength expressed as peak torque percentage relative to the contralateral limb using a standardized testing protocol.

## Secondary Outcomes

- **International Knee Documentation Committee (IKDC) Score** _(time frame: 12 months postoperatively)_
- **Time to Return to Athletic Activity** _(time frame: Up to 12 months postoperatively)_
- **Postoperative Complications** _(time frame: Up to 60 months postoperatively)_
- **Knee function using KOOS score** _(time frame: 60 months postoperatively)_

## Locations (1)

- Kasr Al-Ainy Hospital, Cairo University, Cairo, Cairo Governorate, Egypt

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.kasr al-ainy hospital, cairo university|cairo|cairo governorate|egypt` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT07573293.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT07573293*  
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