--- title: "Dietary Interventions in the Secondary Prevention of Myocardial Infarction: Focus on Plant-Based Nutrition" nct_id: NCT07576400 overall_status: COMPLETED phase: NA sponsor: Radana Dymáčková study_type: INTERVENTIONAL primary_condition: Myocardial Infarction First countries: Czechia canonical_url: "https://parkinsonspathways.com/agent/trials/NCT07576400.md" clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07576400" ct_last_update_post_date: 2026-05-08 last_seen_at: "2026-05-12T07:19:41.485Z" source: ClinicalTrials.gov (mirrored, no enrichment) --- # Dietary Interventions in the Secondary Prevention of Myocardial Infarction: Focus on Plant-Based Nutrition **Official Title:** The Role of Diet in the Secondary Prevention of Myocardial Infarction, With a Focus on a Plant-Based Diet **NCT ID:** [NCT07576400](https://clinicaltrials.gov/study/NCT07576400) ## Key Facts - **Status:** COMPLETED - **Phase:** NA - **Study Type:** INTERVENTIONAL - **Target Enrollment:** 24 - **Lead Sponsor:** Radana Dymáčková - **Collaborators:** Masaryk University - **Conditions:** Myocardial Infarction First - **Start Date:** 2022-01-20 - **Completion Date:** 2025-12-01 - **CT.gov Last Update:** 2026-05-08 ## Brief Summary The goal of this clinical trial is to evaluate whether short-term dietary interventions can improve cardiometabolic risk factors in patients after myocardial infarction. The study includes adult patients following myocardial infarction. The main questions it aims to answer are: * Does adherence to an ESC-recommended diet lead to improvements in lipid profile and body composition compared with no dietary intervention? * Does a plant-based (vegan) diet lead to similar or greater improvements in cardiometabolic parameters compared with the control group? Researchers will compare the ESC diet group and the plant-based diet group with a control group to assess their effects on body mass index, lipid profile, and inflammatory markers. Participants will: * be assigned to one of three groups (ESC diet, plant-based diet, or control), * receive dietary counselling according to their assigned group (intervention groups), * follow the assigned dietary pattern for 3 months, * undergo baseline and follow-up clinical and laboratory assessments, including anthropometric measurements and blood sampling. ## Detailed Description This was a single-center, three-arm, controlled, partially randomized interventional pilot study designed to evaluate the feasibility and potential effects of dietary modification in the secondary prevention of myocardial infarction over a three-month period. Participants were recruited between January 2022 and December 2025. The study duration was three months. Participants who agreed to change their dietary habits were randomized in a 1:1 ratio into two intervention groups using stratified block randomization according to diabetes mellitus status and smoking status. Group A followed a diet based on the recommendations of the European Society of Cardiology (ESC), while Group B adopted a strictly plant-based (vegan) diet. Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group (Group C), based on patient preference. All participants underwent clinical and laboratory assessments at baseline and at three months, including body composition analysis using bioimpedance (InBody). In the intervention groups, additional scheduled visits were conducted at monthly intervals during the three-month period. At these visits, participants received nutritional counseling from a registered dietitian and completed a three-day dietary record to assess dietary intake and adherence. Participants were additionally allowed to contact the dietitian or the study physician outside the scheduled visits if needed. Laboratory analyses included lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein(a), triglycerides), glycemic parameters (fasting blood glucose, glycated hemoglobin HbA1c), inflammatory markers (high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6)), vitamin B12, vitamin D, iron metabolism, complete blood count, and basic biochemical parameters. Patient recruitment was conducted in collaboration with the coronary care unit of St. Anne's University Hospital Brno (FNUSA). Nutritional counselling was delivered by trained Master's degree nutrition therapy students from the Faculty of Medicine, Masaryk University. ## Eligibility - **Minimum age:** 18 Years - **Maximum age:** 70 Years - **Sex:** ALL - **Healthy Volunteers:** No ``` Inclusion Criteria: * Myocardial Infarction First Exclusion Criteria: * Myocardial Infarction Second * Age under 18 ``` ## Arms - **Plant based diet** (EXPERIMENTAL) — The intervention arm, in which participants switch to a strictly plant-based (vegan) diet for three months. - **Diet based on the recommendations of the European Society of Cardiology** (EXPERIMENTAL) — The intervention arm, in which participants switch to a diet based on the recommendations of the European Society of Cardiology for three months. - **Control arm** (NO_INTERVENTION) — Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group. ## Interventions - **Plant based diet** (OTHER) — Change dietary habits for tree months - **Diet based on the recommendations of the European Society of Cardiology** (OTHER) — Change dietary habits for tree months ## Primary Outcomes - **Percentage of participants enrolled in the study** _(time frame: 48 months)_ — In percentage terms, the number of patients contacted and the proportion of those who were subsequently enrolled. - **Percentage of participants completed the study** _(time frame: 3 month)_ — Percentage of the enrolled patients completed the study. ## Secondary Outcomes - **Changes in weight after diet changes** _(time frame: 3 months)_ - **Changes in viceral fat area after diet changes** _(time frame: 3 month)_ - **Changes in skeletal muscle mass after diet changes** _(time frame: 3 month)_ - **Changes in body fat mass after diet changes** _(time frame: 3 month)_ - **Changes in total body water after diet changes** _(time frame: 3 month)_ - **Changes in body mass index after diet changes** _(time frame: 3 month)_ - **Changes in glycated hemoglobin after diet changes** _(time frame: 3 month)_ - **Changes in potassium after diet changes** _(time frame: 3 month)_ - **Changes in magnesium after diet changes** _(time frame: 3 month)_ - **Changes in iron after diet changes** _(time frame: 3 month)_ - **Changes in fasting glucose after diet changes** _(time frame: 3 month)_ - **Changes in total cholesterol after diet changes** _(time frame: 3 month)_ - **Changes in LDL-cholesterol after diet changes** _(time frame: 3 month)_ - **Changes in HDL-cholesterol after diet changes** _(time frame: 3 month)_ - **Changes in triglycerides after diet changes** _(time frame: 3 month)_ - **Changes in lipoprotein(a) after diet changes** _(time frame: 3 month)_ - **Changes in IL-6 after diet changes** _(time frame: 3 month)_ - **Changes in hsCRP after diet changes** _(time frame: 3 month)_ - **Changes in vitamin B12 after diet changes** _(time frame: 3 month)_ - **Changes in 25-hydroxyvitamin D after diet changes** _(time frame: 3 month)_ - **Changes in ferritin after diet changes** _(time frame: 3 month)_ - **Changes in transferin after diet changes** _(time frame: 3 month)_ - **Changes in hemoglobin after diet changes** _(time frame: 3 month)_ - **Changes in body fat after diet changes** _(time frame: 3 month)_ - **Changes in calcium after diet changes** _(time frame: 3 month)_ ## Locations (1) - Masaryk university, Brno, Czechia ## Recent Field Changes (last 30 days) - `status.overallStatus` — added _(2026-05-12)_ - `status.primaryCompletionDate` — added _(2026-05-12)_ - `status.completionDate` — added _(2026-05-12)_ - `status.lastUpdatePostDate` — added _(2026-05-12)_ - `design.phases` — added _(2026-05-12)_ - `design.enrollmentCount` — added _(2026-05-12)_ - `eligibility.criteria` — added _(2026-05-12)_ - `eligibility.minAge` — added _(2026-05-12)_ - `eligibility.maxAge` — added _(2026-05-12)_ - `eligibility.sex` — added _(2026-05-12)_ - `outcomes.primary` — added _(2026-05-12)_ - `outcomes.secondary` — added _(2026-05-12)_ - `armsInterventions.arms` — added _(2026-05-12)_ - `armsInterventions.interventions` — added _(2026-05-12)_ - `sponsor.lead` — added _(2026-05-12)_ - `sponsor.collaborators` — added _(2026-05-12)_ - `results.hasResults` — added _(2026-05-12)_ - `locations.masaryk university|brno||czechia` — added _(2026-05-12)_ --- *Canonical: https://parkinsonspathways.com/agent/trials/NCT07576400.md* *Source data (authoritative): https://clinicaltrials.gov/study/NCT07576400* *This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*