# Parkinson's Pathways

> A free, family-friendly guide to every recruiting Parkinson's disease clinical trial. Currently tracking 507 trials.

## About

Parkinson's Pathways helps patients, caregivers, and clinicians find and understand Parkinson's clinical trials. Every trial is translated for families with a five-word goal, eligibility details, and nearby locations.

Two distinct content tiers are exposed here:

1. **PD Curated**: Parkinson's-only trials with AI-generated family-friendly summaries, five-word goals, geocoded sites, and recent site-change tracking.
2. **Universal Raw Mirror**: A larger, condition-agnostic mirror of ClinicalTrials.gov with no AI summaries and no editorial enrichment. Use this when you need source-of-truth raw data.

Selected content families expose clean Markdown twins (append `.md` to the URL) with YAML frontmatter, intended for LLM ingestion. Supported patterns: `/learn/{slug}.md`, `/caregivers.md`, `/caregivers/{slug}.md`, `/trial/{nctId}.md`, `/trials-near-me.md`, `/trials-near-me/{city}.md`, `/trials/{type}/{slug}.md`, `/trials/eu/{euctId}.md`. Pages such as `/`, `/about`, `/trials`, `/insights`, `/match`, and `/digest` do not have Markdown twins.

## Key Pages

- [Browse All Trials](https://parkinsonspathways.com/trials): Search and filter all 507 recruiting Parkinson's clinical trials by phase, study type, enrollment size, country, and age eligibility.
- [Trials Near Me](https://parkinsonspathways.com/trials-near-me): Find clinical trials near a specific location using zip code or city search.
- [Trial Outcomes & Results Tracker](https://parkinsonspathways.com/results): Completed, terminated, and withdrawn Parkinson's trials, with results and publications as they become available (Markdown twin at https://parkinsonspathways.com/results.md).
- [Insights Dashboard](https://parkinsonspathways.com/insights): Visual overview of the Parkinson's trial landscape, including phase breakdown, intervention types, top sponsors, eligibility stats, and a global map.
- [Learn](https://parkinsonspathways.com/learn): Educational articles explaining clinical trial concepts, translated for families.
- [For Caregivers](https://parkinsonspathways.com/caregivers): Family-first guides for Parkinson's caregivers, medication routines, burnout, legal and financial paperwork, and the care partner's role in clinical trials.
- [About](https://parkinsonspathways.com/about): The story behind the project and how it works.

## PD Curated: Learn Articles (Markdown twins)

Each article is available as both HTML (for humans) and Markdown (for LLM ingestion). Markdown URLs include YAML frontmatter with title, description, canonical URL, and publication date.

- Why I Built Parkinson's Pathways, HTML: https://parkinsonspathways.com/learn/why-i-built-parkinsons-pathways, Markdown: https://parkinsonspathways.com/learn/why-i-built-parkinsons-pathways.md
- What Do Clinical Trial Phases Mean?, HTML: https://parkinsonspathways.com/learn/what-do-clinical-trial-phases-mean, Markdown: https://parkinsonspathways.com/learn/what-do-clinical-trial-phases-mean.md
- What Do Clinical Trial Statuses Mean?, HTML: https://parkinsonspathways.com/learn/what-do-clinical-trial-statuses-mean, Markdown: https://parkinsonspathways.com/learn/what-do-clinical-trial-statuses-mean.md
- How Long Does a Parkinson's Clinical Trial Last?, HTML: https://parkinsonspathways.com/learn/how-long-does-a-parkinsons-clinical-trial-last, Markdown: https://parkinsonspathways.com/learn/how-long-does-a-parkinsons-clinical-trial-last.md
- How to Talk to Your Neurologist About Clinical Trials, HTML: https://parkinsonspathways.com/learn/how-to-talk-to-your-neurologist-about-clinical-trials, Markdown: https://parkinsonspathways.com/learn/how-to-talk-to-your-neurologist-about-clinical-trials.md
- How to Spot a Questionable Clinical Trial, HTML: https://parkinsonspathways.com/learn/how-to-spot-a-questionable-clinical-trial, Markdown: https://parkinsonspathways.com/learn/how-to-spot-a-questionable-clinical-trial.md
- Just Diagnosed with Parkinson's? Where to Start with Clinical Trials, HTML: https://parkinsonspathways.com/learn/just-diagnosed-with-parkinsons-clinical-trials, Markdown: https://parkinsonspathways.com/learn/just-diagnosed-with-parkinsons-clinical-trials.md
- Stem Cell Therapy for Parkinson's: What You Should Actually Know, HTML: https://parkinsonspathways.com/learn/stem-cell-therapy-for-parkinsons, Markdown: https://parkinsonspathways.com/learn/stem-cell-therapy-for-parkinsons.md
- Will My Family Member Get a Placebo?, HTML: https://parkinsonspathways.com/learn/will-my-family-member-get-a-placebo, Markdown: https://parkinsonspathways.com/learn/will-my-family-member-get-a-placebo.md
- How Close Is a Cure for Parkinson's Disease?, HTML: https://parkinsonspathways.com/learn/how-close-is-a-cure-for-parkinsons, Markdown: https://parkinsonspathways.com/learn/how-close-is-a-cure-for-parkinsons.md
- Parkinson's and Dementia: Clinical Trials Families Should Know, HTML: https://parkinsonspathways.com/learn/parkinsons-and-dementia-clinical-trials, Markdown: https://parkinsonspathways.com/learn/parkinsons-and-dementia-clinical-trials.md
- What Is Levodopa and How Does It Work?, HTML: https://parkinsonspathways.com/learn/what-is-levodopa-and-how-does-it-work, Markdown: https://parkinsonspathways.com/learn/what-is-levodopa-and-how-does-it-work.md
- What to Expect in the First Year After Diagnosis, HTML: https://parkinsonspathways.com/learn/what-to-expect-first-year-after-parkinsons-diagnosis, Markdown: https://parkinsonspathways.com/learn/what-to-expect-first-year-after-parkinsons-diagnosis.md
- Diet and Parkinson's Risk: What the Research Says, HTML: https://parkinsonspathways.com/learn/diet-and-parkinsons-risk, Markdown: https://parkinsonspathways.com/learn/diet-and-parkinsons-risk.md
- ClinicalTrials.gov vs Parkinson's Pathways, HTML: https://parkinsonspathways.com/learn/clinicaltrials-gov-vs-parkinsons-pathways, Markdown: https://parkinsonspathways.com/learn/clinicaltrials-gov-vs-parkinsons-pathways.md
- Interventional vs Observational Parkinson's Trials, HTML: https://parkinsonspathways.com/learn/interventional-vs-observational-parkinsons-trials, Markdown: https://parkinsonspathways.com/learn/interventional-vs-observational-parkinsons-trials.md
- Phase 1 vs Phase 2 vs Phase 3 Trials, HTML: https://parkinsonspathways.com/learn/phase-1-vs-phase-2-vs-phase-3-trials, Markdown: https://parkinsonspathways.com/learn/phase-1-vs-phase-2-vs-phase-3-trials.md
- Disease-Modifying vs Symptomatic Parkinson's Trials, HTML: https://parkinsonspathways.com/learn/disease-modifying-vs-symptomatic-parkinsons-trials, Markdown: https://parkinsonspathways.com/learn/disease-modifying-vs-symptomatic-parkinsons-trials.md
- Industry-Sponsored vs Academic Parkinson's Trials, HTML: https://parkinsonspathways.com/learn/industry-sponsored-vs-academic-parkinsons-trials, Markdown: https://parkinsonspathways.com/learn/industry-sponsored-vs-academic-parkinsons-trials.md
- Clinical Trial vs Standard of Care, HTML: https://parkinsonspathways.com/learn/clinical-trial-vs-standard-of-care-parkinsons, Markdown: https://parkinsonspathways.com/learn/clinical-trial-vs-standard-of-care-parkinsons.md
- dbs-vs-duopa-vs-focused-ultrasound-parkinsons, HTML: https://parkinsonspathways.com/learn/dbs-vs-duopa-vs-focused-ultrasound-parkinsons, Markdown: https://parkinsonspathways.com/learn/dbs-vs-duopa-vs-focused-ultrasound-parkinsons.md
- parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa, HTML: https://parkinsonspathways.com/learn/parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa, Markdown: https://parkinsonspathways.com/learn/parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa.md
- parkinsons-vs-essential-tremor, HTML: https://parkinsonspathways.com/learn/parkinsons-vs-essential-tremor, Markdown: https://parkinsonspathways.com/learn/parkinsons-vs-essential-tremor.md
- levodopa-vs-dopamine-agonists, HTML: https://parkinsonspathways.com/learn/levodopa-vs-dopamine-agonists, Markdown: https://parkinsonspathways.com/learn/levodopa-vs-dopamine-agonists.md
- carbidopa-levodopa-formulations-compared, HTML: https://parkinsonspathways.com/learn/carbidopa-levodopa-formulations-compared, Markdown: https://parkinsonspathways.com/learn/carbidopa-levodopa-formulations-compared.md
- glp1-drugs-parkinsons-research, HTML: https://parkinsonspathways.com/learn/glp1-drugs-parkinsons-research, Markdown: https://parkinsonspathways.com/learn/glp1-drugs-parkinsons-research.md
- tavapadon-new-parkinsons-drug-2026, HTML: https://parkinsonspathways.com/learn/tavapadon-new-parkinsons-drug-2026, Markdown: https://parkinsonspathways.com/learn/tavapadon-new-parkinsons-drug-2026.md
- state-of-parkinsons-clinical-trials, HTML: https://parkinsonspathways.com/learn/state-of-parkinsons-clinical-trials, Markdown: https://parkinsonspathways.com/learn/state-of-parkinsons-clinical-trials.md
- where-parkinsons-clinical-trials-happen, HTML: https://parkinsonspathways.com/learn/where-parkinsons-clinical-trials-happen, Markdown: https://parkinsonspathways.com/learn/where-parkinsons-clinical-trials-happen.md

## PD Curated: Caregiver Guides (Markdown twins)

Family-first guides for Parkinson's caregivers, available as both HTML (for humans) and Markdown (for LLM ingestion).

- The First Things to Do When You Become a Caregiver, HTML: https://parkinsonspathways.com/caregivers/first-things-to-do-when-you-become-a-caregiver, Markdown: https://parkinsonspathways.com/caregivers/first-things-to-do-when-you-become-a-caregiver.md
- Building Your Person's Care Team, HTML: https://parkinsonspathways.com/caregivers/building-your-persons-care-team, Markdown: https://parkinsonspathways.com/caregivers/building-your-persons-care-team.md
- Talking to Kids About a Parent's or Grandparent's Parkinson's, HTML: https://parkinsonspathways.com/caregivers/talking-to-kids-about-a-parents-parkinsons, Markdown: https://parkinsonspathways.com/caregivers/talking-to-kids-about-a-parents-parkinsons.md
- Anticipatory Grief: Mourning Someone Who Is Still Here, HTML: https://parkinsonspathways.com/caregivers/anticipatory-grief-parkinsons-caregiver, Markdown: https://parkinsonspathways.com/caregivers/anticipatory-grief-parkinsons-caregiver.md
- Managing Medication Schedules When Timing Actually Matters, HTML: https://parkinsonspathways.com/caregivers/managing-medication-schedules-parkinsons, Markdown: https://parkinsonspathways.com/caregivers/managing-medication-schedules-parkinsons.md
- Caregiver Burnout Is Not a Character Flaw, HTML: https://parkinsonspathways.com/caregivers/caregiver-burnout-is-not-a-character-flaw, Markdown: https://parkinsonspathways.com/caregivers/caregiver-burnout-is-not-a-character-flaw.md
- Power of Attorney and Advance Directives: Do It Now, Not Later, HTML: https://parkinsonspathways.com/caregivers/power-of-attorney-and-advance-directives-parkinsons, Markdown: https://parkinsonspathways.com/caregivers/power-of-attorney-and-advance-directives-parkinsons.md
- When Your Person Can't Consent: Legal and Ethical Considerations for Trial Enrollment, HTML: https://parkinsonspathways.com/caregivers/when-your-person-cant-consent-clinical-trial-enrollment, Markdown: https://parkinsonspathways.com/caregivers/when-your-person-cant-consent-clinical-trial-enrollment.md
- Your Role During a Clinical Trial: What to Expect as the Care Partner, HTML: https://parkinsonspathways.com/caregivers/your-role-during-a-clinical-trial-care-partner, Markdown: https://parkinsonspathways.com/caregivers/your-role-during-a-clinical-trial-care-partner.md

## PD Curated: Trial Pages (Markdown twins)

Every recruiting Parkinson's trial has a Markdown twin at `/trial/{nctId}.md` containing the AI summary, five-word goal, plain-language eligibility, geocoded sites, contact info, and recent site changes (last 30 days). Append `.md` to any `/trial/{nctId}` URL in the sitemap to reach its twin; below are the 50 most recently updated for quick discovery.

- Improve thinking via scalp stimulation (NCT03025334), HTML: https://parkinsonspathways.com/trial/NCT03025334, Markdown: https://parkinsonspathways.com/trial/NCT03025334.md
- Track brain protein loss annually (NCT06456684), HTML: https://parkinsonspathways.com/trial/NCT06456684, Markdown: https://parkinsonspathways.com/trial/NCT06456684.md
- Identify rare genes causing Parkinsons (NCT05721911), HTML: https://parkinsonspathways.com/trial/NCT05721911, Markdown: https://parkinsonspathways.com/trial/NCT05721911.md
- Improve balance using Segway training (NCT05982730), HTML: https://parkinsonspathways.com/trial/NCT05982730, Markdown: https://parkinsonspathways.com/trial/NCT05982730.md
- Improve social engagement and mood (NCT06385184), HTML: https://parkinsonspathways.com/trial/NCT06385184, Markdown: https://parkinsonspathways.com/trial/NCT06385184.md
- Detect early brain chemical changes (NCT04735172), HTML: https://parkinsonspathways.com/trial/NCT04735172, Markdown: https://parkinsonspathways.com/trial/NCT04735172.md
- Collect genes to guide care (NCT04994015), HTML: https://parkinsonspathways.com/trial/NCT04994015, Markdown: https://parkinsonspathways.com/trial/NCT04994015.md
- Determine whether immunosuppression slows progression (NCT06834191), HTML: https://parkinsonspathways.com/trial/NCT06834191, Markdown: https://parkinsonspathways.com/trial/NCT06834191.md
- Adaptive stimulation improves motor control (NCT07216976), HTML: https://parkinsonspathways.com/trial/NCT07216976, Markdown: https://parkinsonspathways.com/trial/NCT07216976.md
- Validate scale measuring involuntary movements (NCT07023224), HTML: https://parkinsonspathways.com/trial/NCT07023224, Markdown: https://parkinsonspathways.com/trial/NCT07023224.md
- Differentiate dementias using brain imaging (NCT03019757), HTML: https://parkinsonspathways.com/trial/NCT03019757, Markdown: https://parkinsonspathways.com/trial/NCT03019757.md
- Identify genetic causes in families (NCT03508986), HTML: https://parkinsonspathways.com/trial/NCT03508986, Markdown: https://parkinsonspathways.com/trial/NCT03508986.md
- Reduce tremor slowness and stiffness (NCT07348705), HTML: https://parkinsonspathways.com/trial/NCT07348705, Markdown: https://parkinsonspathways.com/trial/NCT07348705.md
- Improve postoperative complication risk stratification (NCT03945968), HTML: https://parkinsonspathways.com/trial/NCT03945968, Markdown: https://parkinsonspathways.com/trial/NCT03945968.md
- Decrease resting hand tremor electrically (NCT06646510), HTML: https://parkinsonspathways.com/trial/NCT06646510, Markdown: https://parkinsonspathways.com/trial/NCT06646510.md
- Aerobic exercise slows Parkinson progression (NCT05854524), HTML: https://parkinsonspathways.com/trial/NCT05854524, Markdown: https://parkinsonspathways.com/trial/NCT05854524.md
- Vibrating shoe increases walking speed (NCT07308418), HTML: https://parkinsonspathways.com/trial/NCT07308418, Markdown: https://parkinsonspathways.com/trial/NCT07308418.md
- Clear harmful brain protein clumps (NCT07157345), HTML: https://parkinsonspathways.com/trial/NCT07157345, Markdown: https://parkinsonspathways.com/trial/NCT07157345.md
- Improve obstacle crossing while walking (NCT06932679), HTML: https://parkinsonspathways.com/trial/NCT06932679, Markdown: https://parkinsonspathways.com/trial/NCT06932679.md
- Reduce apathy and boost motivation (NCT07399496), HTML: https://parkinsonspathways.com/trial/NCT07399496, Markdown: https://parkinsonspathways.com/trial/NCT07399496.md
- Improve walking with red light (NCT06916260), HTML: https://parkinsonspathways.com/trial/NCT06916260, Markdown: https://parkinsonspathways.com/trial/NCT06916260.md
- Self managed exercise improves walking (NCT07302386), HTML: https://parkinsonspathways.com/trial/NCT07302386, Markdown: https://parkinsonspathways.com/trial/NCT07302386.md
- Characterize hearing changes in Parkinson (NCT07083089), HTML: https://parkinsonspathways.com/trial/NCT07083089, Markdown: https://parkinsonspathways.com/trial/NCT07083089.md
- Numbing surgical area speeds recovery (NCT07176494), HTML: https://parkinsonspathways.com/trial/NCT07176494, Markdown: https://parkinsonspathways.com/trial/NCT07176494.md
- Improve standing reach and strength (NCT07382674), HTML: https://parkinsonspathways.com/trial/NCT07382674, Markdown: https://parkinsonspathways.com/trial/NCT07382674.md
- Improve slowed movement with stimulation (NCT01682668), HTML: https://parkinsonspathways.com/trial/NCT01682668, Markdown: https://parkinsonspathways.com/trial/NCT01682668.md
- Reduce programming and improve symptoms (NCT06742450), HTML: https://parkinsonspathways.com/trial/NCT06742450, Markdown: https://parkinsonspathways.com/trial/NCT06742450.md
- How brain stimulation affects thinking (NCT06329726), HTML: https://parkinsonspathways.com/trial/NCT06329726, Markdown: https://parkinsonspathways.com/trial/NCT06329726.md
- Magnetic pulses reduce movement stiffness (NCT07306104), HTML: https://parkinsonspathways.com/trial/NCT07306104, Markdown: https://parkinsonspathways.com/trial/NCT07306104.md
- Detect serotonin loss in Parkinson (NCT05516732), HTML: https://parkinsonspathways.com/trial/NCT05516732, Markdown: https://parkinsonspathways.com/trial/NCT05516732.md
- Track disease progression in Parkinson (NCT07353463), HTML: https://parkinsonspathways.com/trial/NCT07353463, Markdown: https://parkinsonspathways.com/trial/NCT07353463.md
- Improve walking with mixed reality (NCT06459154), HTML: https://parkinsonspathways.com/trial/NCT06459154, Markdown: https://parkinsonspathways.com/trial/NCT06459154.md
- Measure internal tremor in Parkinsons (NCT06885541), HTML: https://parkinsonspathways.com/trial/NCT06885541, Markdown: https://parkinsonspathways.com/trial/NCT06885541.md
- Hippotherapy improves balance and mobility (NCT06500182), HTML: https://parkinsonspathways.com/trial/NCT06500182, Markdown: https://parkinsonspathways.com/trial/NCT06500182.md
- Slow early Parkinson disease progression (NCT07174310), HTML: https://parkinsonspathways.com/trial/NCT07174310, Markdown: https://parkinsonspathways.com/trial/NCT07174310.md
- Predict Parkinson progression using neuroimaging (NCT07024875), HTML: https://parkinsonspathways.com/trial/NCT07024875, Markdown: https://parkinsonspathways.com/trial/NCT07024875.md
- Improve targeting for brain stimulation (NCT00575081), HTML: https://parkinsonspathways.com/trial/NCT00575081, Markdown: https://parkinsonspathways.com/trial/NCT00575081.md
- Improve walking via robotic exoskeleton (NCT06225830), HTML: https://parkinsonspathways.com/trial/NCT06225830, Markdown: https://parkinsonspathways.com/trial/NCT06225830.md
- New medication improves brain energy (NCT07322887), HTML: https://parkinsonspathways.com/trial/NCT07322887, Markdown: https://parkinsonspathways.com/trial/NCT07322887.md
- Rebalance neurotransmitter precursors with supplement (NCT07115563), HTML: https://parkinsonspathways.com/trial/NCT07115563, Markdown: https://parkinsonspathways.com/trial/NCT07115563.md
- Blood test tracks Parkinson progression (NCT05769699), HTML: https://parkinsonspathways.com/trial/NCT05769699, Markdown: https://parkinsonspathways.com/trial/NCT05769699.md
- Blood test tracks Parkinson progression (NCT06941012), HTML: https://parkinsonspathways.com/trial/NCT06941012, Markdown: https://parkinsonspathways.com/trial/NCT06941012.md
- Understand brain control of breathing (NCT06074614), HTML: https://parkinsonspathways.com/trial/NCT06074614, Markdown: https://parkinsonspathways.com/trial/NCT06074614.md
- Preserve brain signals during surgery (NCT06543563), HTML: https://parkinsonspathways.com/trial/NCT06543563, Markdown: https://parkinsonspathways.com/trial/NCT06543563.md
- Improve balance through arm function (NCT06591975), HTML: https://parkinsonspathways.com/trial/NCT06591975, Markdown: https://parkinsonspathways.com/trial/NCT06591975.md
- Test febuxostat and inosine neuroprotection (NCT07170475), HTML: https://parkinsonspathways.com/trial/NCT07170475, Markdown: https://parkinsonspathways.com/trial/NCT07170475.md
- Measure cognitive decline in Parkinsons (NCT04997642), HTML: https://parkinsonspathways.com/trial/NCT04997642, Markdown: https://parkinsonspathways.com/trial/NCT04997642.md
- Collaborative virtual reality improves walking (NCT07523425), HTML: https://parkinsonspathways.com/trial/NCT07523425, Markdown: https://parkinsonspathways.com/trial/NCT07523425.md
- Brain injection reduces movement problems (NCT07195825), HTML: https://parkinsonspathways.com/trial/NCT07195825, Markdown: https://parkinsonspathways.com/trial/NCT07195825.md
- Improve gait using Percept neurostimulation (NCT05820074), HTML: https://parkinsonspathways.com/trial/NCT05820074, Markdown: https://parkinsonspathways.com/trial/NCT05820074.md

## Universal Raw Mirror (any condition)

A separate, condition-agnostic mirror of ClinicalTrials.gov. **Raw data only, no AI summaries, no PD-specific filtering, no editorial enrichment.** Use this when you want source-of-truth data with field-level change tracking.

- URL pattern: https://parkinsonspathways.com/agent/trials/{nctId}.md
- Authoritative source: https://clinicaltrials.gov/study/{nctId}

## Agent API

A programmatic API namespace for agents and downstream services is in the works. Entry point will live at `https://parkinsonspathways.com/api/agent/` and will expose change feeds, matching, and replay endpoints. Until that ships, retrieve content via the Markdown URLs above.

## Machine-Readable Resources

- [Sitemap](https://parkinsonspathways.com/sitemap.xml), clean HTML URLs for every public page (only `/trial/{nctId}`, `/learn/{slug}`, `/trials-near-me`, `/trials-near-me/{city}`, `/trials/{type}/{slug}`, and `/trials/eu/{euctId}` entries support a `.md` twin)
- [Sitemap Index](https://parkinsonspathways.com/sitemap-index.xml), references the main sitemap
- [Full LLM Context](https://parkinsonspathways.com/llms-full.txt)