# Parkinson's Pathways

> A free, family-friendly guide to every recruiting Parkinson's disease clinical trial. Currently tracking 502 trials.

## About

Parkinson's Pathways helps patients, caregivers, and clinicians find and understand Parkinson's clinical trials. Every trial is translated for families with a five-word goal, eligibility details, and nearby locations.

Two distinct content tiers are exposed here:

1. **PD Curated** — Parkinson's-only trials with AI-generated family-friendly summaries, five-word goals, geocoded sites, and recent site-change tracking.
2. **Universal Raw Mirror** — A larger, condition-agnostic mirror of ClinicalTrials.gov with no AI summaries and no editorial enrichment. Use this when you need source-of-truth raw data.

Selected content families expose clean Markdown twins (append `.md` to the URL) with YAML frontmatter, intended for LLM ingestion. Supported patterns: `/learn/{slug}.md`, `/trial/{nctId}.md`, `/trials-near-me.md`, `/trials-near-me/{city}.md`, `/trials/{type}/{slug}.md`, `/trials/eu/{euctId}.md`. Pages such as `/`, `/about`, `/trials`, `/insights`, `/match`, and `/digest` do not have Markdown twins.

## Key Pages

- [Browse All Trials](https://parkinsonspathways.com/trials): Search and filter all 502 recruiting Parkinson's clinical trials by phase, study type, enrollment size, country, and age eligibility.
- [Trials Near Me](https://parkinsonspathways.com/trials-near-me): Find clinical trials near a specific location using zip code or city search.
- [Insights Dashboard](https://parkinsonspathways.com/insights): Visual overview of the Parkinson's trial landscape, including phase breakdown, intervention types, top sponsors, eligibility stats, and a global map.
- [Learn](https://parkinsonspathways.com/learn): Educational articles explaining clinical trial concepts, translated for families.
- [About](https://parkinsonspathways.com/about): The story behind the project and how it works.

## PD Curated — Learn Articles (Markdown twins)

Each article is available as both HTML (for humans) and Markdown (for LLM ingestion). Markdown URLs include YAML frontmatter with title, description, canonical URL, and publication date.

- Why I Built Parkinson's Pathways — HTML: https://parkinsonspathways.com/learn/why-i-built-parkinsons-pathways — Markdown: https://parkinsonspathways.com/learn/why-i-built-parkinsons-pathways.md
- What Do Clinical Trial Phases Mean? — HTML: https://parkinsonspathways.com/learn/what-do-clinical-trial-phases-mean — Markdown: https://parkinsonspathways.com/learn/what-do-clinical-trial-phases-mean.md
- What Do Clinical Trial Statuses Mean? — HTML: https://parkinsonspathways.com/learn/what-do-clinical-trial-statuses-mean — Markdown: https://parkinsonspathways.com/learn/what-do-clinical-trial-statuses-mean.md
- How Long Does a Parkinson's Clinical Trial Last? — HTML: https://parkinsonspathways.com/learn/how-long-does-a-parkinsons-clinical-trial-last — Markdown: https://parkinsonspathways.com/learn/how-long-does-a-parkinsons-clinical-trial-last.md
- How to Talk to Your Neurologist About Clinical Trials — HTML: https://parkinsonspathways.com/learn/how-to-talk-to-your-neurologist-about-clinical-trials — Markdown: https://parkinsonspathways.com/learn/how-to-talk-to-your-neurologist-about-clinical-trials.md
- How to Spot a Questionable Clinical Trial — HTML: https://parkinsonspathways.com/learn/how-to-spot-a-questionable-clinical-trial — Markdown: https://parkinsonspathways.com/learn/how-to-spot-a-questionable-clinical-trial.md
- Just Diagnosed with Parkinson's? Where to Start with Clinical Trials — HTML: https://parkinsonspathways.com/learn/just-diagnosed-with-parkinsons-clinical-trials — Markdown: https://parkinsonspathways.com/learn/just-diagnosed-with-parkinsons-clinical-trials.md
- Stem Cell Therapy for Parkinson's: What You Should Actually Know — HTML: https://parkinsonspathways.com/learn/stem-cell-therapy-for-parkinsons — Markdown: https://parkinsonspathways.com/learn/stem-cell-therapy-for-parkinsons.md
- Will My Family Member Get a Placebo? — HTML: https://parkinsonspathways.com/learn/will-my-family-member-get-a-placebo — Markdown: https://parkinsonspathways.com/learn/will-my-family-member-get-a-placebo.md
- How Close Is a Cure for Parkinson's Disease? — HTML: https://parkinsonspathways.com/learn/how-close-is-a-cure-for-parkinsons — Markdown: https://parkinsonspathways.com/learn/how-close-is-a-cure-for-parkinsons.md
- Parkinson's and Dementia: Clinical Trials Families Should Know — HTML: https://parkinsonspathways.com/learn/parkinsons-and-dementia-clinical-trials — Markdown: https://parkinsonspathways.com/learn/parkinsons-and-dementia-clinical-trials.md
- What Is Levodopa and How Does It Work? — HTML: https://parkinsonspathways.com/learn/what-is-levodopa-and-how-does-it-work — Markdown: https://parkinsonspathways.com/learn/what-is-levodopa-and-how-does-it-work.md
- What to Expect in the First Year After Diagnosis — HTML: https://parkinsonspathways.com/learn/what-to-expect-first-year-after-parkinsons-diagnosis — Markdown: https://parkinsonspathways.com/learn/what-to-expect-first-year-after-parkinsons-diagnosis.md
- Diet and Parkinson's Risk: What the Research Says — HTML: https://parkinsonspathways.com/learn/diet-and-parkinsons-risk — Markdown: https://parkinsonspathways.com/learn/diet-and-parkinsons-risk.md
- ClinicalTrials.gov vs Parkinson's Pathways — HTML: https://parkinsonspathways.com/learn/clinicaltrials-gov-vs-parkinsons-pathways — Markdown: https://parkinsonspathways.com/learn/clinicaltrials-gov-vs-parkinsons-pathways.md
- Interventional vs Observational Parkinson's Trials — HTML: https://parkinsonspathways.com/learn/interventional-vs-observational-parkinsons-trials — Markdown: https://parkinsonspathways.com/learn/interventional-vs-observational-parkinsons-trials.md
- Phase 1 vs Phase 2 vs Phase 3 Trials — HTML: https://parkinsonspathways.com/learn/phase-1-vs-phase-2-vs-phase-3-trials — Markdown: https://parkinsonspathways.com/learn/phase-1-vs-phase-2-vs-phase-3-trials.md
- Disease-Modifying vs Symptomatic Parkinson's Trials — HTML: https://parkinsonspathways.com/learn/disease-modifying-vs-symptomatic-parkinsons-trials — Markdown: https://parkinsonspathways.com/learn/disease-modifying-vs-symptomatic-parkinsons-trials.md
- Industry-Sponsored vs Academic Parkinson's Trials — HTML: https://parkinsonspathways.com/learn/industry-sponsored-vs-academic-parkinsons-trials — Markdown: https://parkinsonspathways.com/learn/industry-sponsored-vs-academic-parkinsons-trials.md
- Clinical Trial vs Standard of Care — HTML: https://parkinsonspathways.com/learn/clinical-trial-vs-standard-of-care-parkinsons — Markdown: https://parkinsonspathways.com/learn/clinical-trial-vs-standard-of-care-parkinsons.md
- dbs-vs-duopa-vs-focused-ultrasound-parkinsons — HTML: https://parkinsonspathways.com/learn/dbs-vs-duopa-vs-focused-ultrasound-parkinsons — Markdown: https://parkinsonspathways.com/learn/dbs-vs-duopa-vs-focused-ultrasound-parkinsons.md
- parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa — HTML: https://parkinsonspathways.com/learn/parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa — Markdown: https://parkinsonspathways.com/learn/parkinsons-vs-lewy-body-dementia-vs-psp-vs-msa.md
- parkinsons-vs-essential-tremor — HTML: https://parkinsonspathways.com/learn/parkinsons-vs-essential-tremor — Markdown: https://parkinsonspathways.com/learn/parkinsons-vs-essential-tremor.md
- levodopa-vs-dopamine-agonists — HTML: https://parkinsonspathways.com/learn/levodopa-vs-dopamine-agonists — Markdown: https://parkinsonspathways.com/learn/levodopa-vs-dopamine-agonists.md
- carbidopa-levodopa-formulations-compared — HTML: https://parkinsonspathways.com/learn/carbidopa-levodopa-formulations-compared — Markdown: https://parkinsonspathways.com/learn/carbidopa-levodopa-formulations-compared.md
- glp1-drugs-parkinsons-research — HTML: https://parkinsonspathways.com/learn/glp1-drugs-parkinsons-research — Markdown: https://parkinsonspathways.com/learn/glp1-drugs-parkinsons-research.md
- tavapadon-new-parkinsons-drug-2026 — HTML: https://parkinsonspathways.com/learn/tavapadon-new-parkinsons-drug-2026 — Markdown: https://parkinsonspathways.com/learn/tavapadon-new-parkinsons-drug-2026.md
- state-of-parkinsons-clinical-trials — HTML: https://parkinsonspathways.com/learn/state-of-parkinsons-clinical-trials — Markdown: https://parkinsonspathways.com/learn/state-of-parkinsons-clinical-trials.md
- where-parkinsons-clinical-trials-happen — HTML: https://parkinsonspathways.com/learn/where-parkinsons-clinical-trials-happen — Markdown: https://parkinsonspathways.com/learn/where-parkinsons-clinical-trials-happen.md

## PD Curated — Trial Pages (Markdown twins)

Every recruiting Parkinson's trial has a Markdown twin at `/trial/{nctId}.md` containing the AI summary, five-word goal, plain-language eligibility, geocoded sites, contact info, and recent site changes (last 30 days). Append `.md` to any `/trial/{nctId}` URL in the sitemap to reach its twin; below are the 50 most recently updated for quick discovery.

- Reduce tremor using brain stimulation (NCT05752656) — HTML: https://parkinsonspathways.com/trial/NCT05752656 — Markdown: https://parkinsonspathways.com/trial/NCT05752656.md
- Reduce slowness stiffness and instability (NCT06383247) — HTML: https://parkinsonspathways.com/trial/NCT06383247 — Markdown: https://parkinsonspathways.com/trial/NCT06383247.md
- Predict brain stimulation easing freezing (NCT06951906) — HTML: https://parkinsonspathways.com/trial/NCT06951906 — Markdown: https://parkinsonspathways.com/trial/NCT06951906.md
- Adaptive stimulation improves motor control (NCT07216976) — HTML: https://parkinsonspathways.com/trial/NCT07216976 — Markdown: https://parkinsonspathways.com/trial/NCT07216976.md
- Improve cough strength using SpiroGym (NCT06481540) — HTML: https://parkinsonspathways.com/trial/NCT06481540 — Markdown: https://parkinsonspathways.com/trial/NCT06481540.md
- Retinal imaging detects early Parkinson (NCT07244640) — HTML: https://parkinsonspathways.com/trial/NCT07244640 — Markdown: https://parkinsonspathways.com/trial/NCT07244640.md
- Test radotinib to slow progression (NCT04691661) — HTML: https://parkinsonspathways.com/trial/NCT04691661 — Markdown: https://parkinsonspathways.com/trial/NCT04691661.md
- Test drug safety in Parkinson (NCT06466525) — HTML: https://parkinsonspathways.com/trial/NCT06466525 — Markdown: https://parkinsonspathways.com/trial/NCT06466525.md
- Reduce tremor stiffness and slowness (NCT06169852) — HTML: https://parkinsonspathways.com/trial/NCT06169852 — Markdown: https://parkinsonspathways.com/trial/NCT06169852.md
- Reduce freezing episodes during walking (NCT06982638) — HTML: https://parkinsonspathways.com/trial/NCT06982638 — Markdown: https://parkinsonspathways.com/trial/NCT06982638.md
- Test tenapanor for Parkinson constipation (NCT06460038) — HTML: https://parkinsonspathways.com/trial/NCT06460038 — Markdown: https://parkinsonspathways.com/trial/NCT06460038.md
- Improve walking endurance through exercise (NCT07221266) — HTML: https://parkinsonspathways.com/trial/NCT07221266 — Markdown: https://parkinsonspathways.com/trial/NCT07221266.md
- Measure emotional response to music (NCT06688968) — HTML: https://parkinsonspathways.com/trial/NCT06688968 — Markdown: https://parkinsonspathways.com/trial/NCT06688968.md
- Reduce tremor and improve movement (NCT06400017) — HTML: https://parkinsonspathways.com/trial/NCT06400017 — Markdown: https://parkinsonspathways.com/trial/NCT06400017.md
- Reduce freezing episodes while walking (NCT06570421) — HTML: https://parkinsonspathways.com/trial/NCT06570421 — Markdown: https://parkinsonspathways.com/trial/NCT06570421.md
- Detect early Parkinson brain changes (NCT04101968) — HTML: https://parkinsonspathways.com/trial/NCT04101968 — Markdown: https://parkinsonspathways.com/trial/NCT04101968.md
- Improve deep sleep and thinking (NCT07441915) — HTML: https://parkinsonspathways.com/trial/NCT07441915 — Markdown: https://parkinsonspathways.com/trial/NCT07441915.md
- Predict individual Parkinson disease progression (NCT05065060) — HTML: https://parkinsonspathways.com/trial/NCT05065060 — Markdown: https://parkinsonspathways.com/trial/NCT05065060.md
- Improve walking balance and thinking (NCT06868160) — HTML: https://parkinsonspathways.com/trial/NCT06868160 — Markdown: https://parkinsonspathways.com/trial/NCT06868160.md
- New medication restores daily motivation (NCT07461220) — HTML: https://parkinsonspathways.com/trial/NCT07461220 — Markdown: https://parkinsonspathways.com/trial/NCT07461220.md
- Improve patient mood with compassion (NCT07097298) — HTML: https://parkinsonspathways.com/trial/NCT07097298 — Markdown: https://parkinsonspathways.com/trial/NCT07097298.md
- Image brain alpha synuclein deposition (NCT07348250) — HTML: https://parkinsonspathways.com/trial/NCT07348250 — Markdown: https://parkinsonspathways.com/trial/NCT07348250.md
- Sensing brain stimulation lengthens sleep (NCT05070013) — HTML: https://parkinsonspathways.com/trial/NCT05070013 — Markdown: https://parkinsonspathways.com/trial/NCT05070013.md
- Detect inherited Parkinson gene variants (NCT02760108) — HTML: https://parkinsonspathways.com/trial/NCT02760108 — Markdown: https://parkinsonspathways.com/trial/NCT02760108.md
- Restore glucocerebrosidase activity in putamen (NCT05565443) — HTML: https://parkinsonspathways.com/trial/NCT05565443 — Markdown: https://parkinsonspathways.com/trial/NCT05565443.md
- Map dopamine signals for mood (NCT07402928) — HTML: https://parkinsonspathways.com/trial/NCT07402928 — Markdown: https://parkinsonspathways.com/trial/NCT07402928.md
- Improve walking with transcranial stimulation (NCT07291687) — HTML: https://parkinsonspathways.com/trial/NCT07291687 — Markdown: https://parkinsonspathways.com/trial/NCT07291687.md
- Atomoxetine reduces freezing of gait (NCT07316296) — HTML: https://parkinsonspathways.com/trial/NCT07316296 — Markdown: https://parkinsonspathways.com/trial/NCT07316296.md
- Measure dance exercise energy expenditure (NCT06425731) — HTML: https://parkinsonspathways.com/trial/NCT06425731 — Markdown: https://parkinsonspathways.com/trial/NCT06425731.md
- Probiotic cocktail delays Parkinson progression (NCT07619560) — HTML: https://parkinsonspathways.com/trial/NCT07619560 — Markdown: https://parkinsonspathways.com/trial/NCT07619560.md
- Aerobic exercise slows Parkinson progression (NCT05854524) — HTML: https://parkinsonspathways.com/trial/NCT05854524 — Markdown: https://parkinsonspathways.com/trial/NCT05854524.md
- Track axial and cognitive progression (NCT07187843) — HTML: https://parkinsonspathways.com/trial/NCT07187843 — Markdown: https://parkinsonspathways.com/trial/NCT07187843.md
- Alleviate gait freezing and instability (NCT06295614) — HTML: https://parkinsonspathways.com/trial/NCT06295614 — Markdown: https://parkinsonspathways.com/trial/NCT06295614.md
- Detect cognitive decline from speech (NCT05765110) — HTML: https://parkinsonspathways.com/trial/NCT05765110 — Markdown: https://parkinsonspathways.com/trial/NCT05765110.md
- Reduce off time and fluctuations (NCT07219927) — HTML: https://parkinsonspathways.com/trial/NCT07219927 — Markdown: https://parkinsonspathways.com/trial/NCT07219927.md
- Improve walking and movement control (NCT07309198) — HTML: https://parkinsonspathways.com/trial/NCT07309198 — Markdown: https://parkinsonspathways.com/trial/NCT07309198.md
- Transplant restores dopamine producing cells (NCT06482268) — HTML: https://parkinsonspathways.com/trial/NCT06482268 — Markdown: https://parkinsonspathways.com/trial/NCT06482268.md
- Reduce hallucinations without worsening movement (NCT04373317) — HTML: https://parkinsonspathways.com/trial/NCT04373317 — Markdown: https://parkinsonspathways.com/trial/NCT04373317.md
- New medication slows Parkinson progression (NCT06976268) — HTML: https://parkinsonspathways.com/trial/NCT06976268 — Markdown: https://parkinsonspathways.com/trial/NCT06976268.md
- Predict benefit from brain stimulation (NCT07376278) — HTML: https://parkinsonspathways.com/trial/NCT07376278 — Markdown: https://parkinsonspathways.com/trial/NCT07376278.md
- Improve posture and trunk flexibility (NCT06536478) — HTML: https://parkinsonspathways.com/trial/NCT06536478 — Markdown: https://parkinsonspathways.com/trial/NCT06536478.md
- Brain scan detects immune activity (NCT05395624) — HTML: https://parkinsonspathways.com/trial/NCT05395624 — Markdown: https://parkinsonspathways.com/trial/NCT05395624.md
- Reduce off period motor fluctuations (NCT07166757) — HTML: https://parkinsonspathways.com/trial/NCT07166757 — Markdown: https://parkinsonspathways.com/trial/NCT07166757.md
- Replace lost dopamine producing neurons (NCT06167681) — HTML: https://parkinsonspathways.com/trial/NCT06167681 — Markdown: https://parkinsonspathways.com/trial/NCT06167681.md
- Improve gait balance and attention (NCT07465107) — HTML: https://parkinsonspathways.com/trial/NCT07465107 — Markdown: https://parkinsonspathways.com/trial/NCT07465107.md
- Blood test tracks Parkinson progression (NCT06941012) — HTML: https://parkinsonspathways.com/trial/NCT06941012 — Markdown: https://parkinsonspathways.com/trial/NCT06941012.md
- Cell transplant reduces off time (NCT07080775) — HTML: https://parkinsonspathways.com/trial/NCT07080775 — Markdown: https://parkinsonspathways.com/trial/NCT07080775.md
- Improve balance through arm function (NCT06591975) — HTML: https://parkinsonspathways.com/trial/NCT06591975 — Markdown: https://parkinsonspathways.com/trial/NCT06591975.md
- Reduce tremor through neurosurgical evaluation (NCT00060541) — HTML: https://parkinsonspathways.com/trial/NCT00060541 — Markdown: https://parkinsonspathways.com/trial/NCT00060541.md
- Distinguish reflexive tightness from stiffness (NCT06596187) — HTML: https://parkinsonspathways.com/trial/NCT06596187 — Markdown: https://parkinsonspathways.com/trial/NCT06596187.md

## Universal Raw Mirror (any condition)

A separate, condition-agnostic mirror of ClinicalTrials.gov. **Raw data only — no AI summaries, no PD-specific filtering, no editorial enrichment.** Use this when you want source-of-truth data with field-level change tracking.

- URL pattern: https://parkinsonspathways.com/agent/trials/{nctId}.md
- Authoritative source: https://clinicaltrials.gov/study/{nctId}

## Agent API

A programmatic API namespace for agents and downstream services is in the works. Entry point will live at `https://parkinsonspathways.com/api/agent/` and will expose change feeds, matching, and replay endpoints. Until that ships, retrieve content via the Markdown URLs above.

## Machine-Readable Resources

- [Sitemap](https://parkinsonspathways.com/sitemap.xml) — clean HTML URLs for every public page (only `/trial/{nctId}`, `/learn/{slug}`, `/trials-near-me`, `/trials-near-me/{city}`, `/trials/{type}/{slug}`, and `/trials/eu/{euctId}` entries support a `.md` twin)
- [Sitemap Index](https://parkinsonspathways.com/sitemap-index.xml) — references the main sitemap
- [Full LLM Context](https://parkinsonspathways.com/llms-full.txt)