---
title: Reduce tremor through neurosurgical evaluation
nct_id: NCT00060541
status: RECRUITING
sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT00060541"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT00060541"
last_fetched: "2026-05-10T14:06:41.816Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce tremor through neurosurgical evaluation

**Goal (in five words):** Reduce tremor through neurosurgical evaluation

**Official Title:** Evaluation and Treatment of Neurosurgical Disorders

**Trial ID:** [NCT00060541](https://clinicaltrials.gov/study/NCT00060541)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** National Institute of Neurological Disorders and Stroke (NINDS)
- **Target Enrollment:** 5000 participants
- **Start Date:** 2003-06-04
- **Conditions:** Neurologic Disorders
- **Interventions:** Laboratory tests, Radiological exams
- **Intervention Types:** PROCEDURE

## Summary For Families

The goal is to evaluate and manage people with a wide range of neurosurgical problems, including Parkinson's disease, so clinicians can improve diagnosis, guide treatment decisions, and build a research resource of clinical data and biological samples. Participants get detailed clinical exams, lab tests, imaging like MRI, and optional skin, saliva, or blood samples and genetic testing to characterize the problem and decide on treatments such as tumor surgery or deep brain stimulation. Deep brain stimulation involves implanting electrodes to modulate overactive brain circuits, which can reduce motor symptoms and often allow lower levodopa doses. People aged 4 and older who are referred to the Surgical Neurology Branch for evaluation and can consent, or have a guardian to consent, are eligible; those unable to undergo evaluation are excluded, and close relatives may enroll for genetic testing only.

## Eligibility

- **Minimum age:** 4 Years
- **Maximum age:** 99 Years
- **Sex:** ALL

### Full Criteria

```
* INCLUSION CRITERIA:

  1. Participants must be age 4 and older.
  2. Participants must seek care from, or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders)
  3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated
  4. For minors: a parent or legal guardian who is able to provide consent.

     For immediate blood relatives of subjects having genetic testing only:
  5. Blood relative of a subject who is suspected to have a genetic mechanism underlying their neurological disorder (for genetic testing only).

EXCLUSION CRITERIA:

1\. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder

3.c. Participant Inclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples)

1. Participants must be age 4 and older.
2. Participants must seek care from or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders)
3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated
4. For minors: a parent or legal guardian who is able to provide consent.
5. Be willing to consent for collection of clinical data or biological samples or their cryopreservation

3.D. Participant Exclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples)

1. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder
2. At the time of enrollment, subjects without an established diagnosis of a wellcharacterized disease entity with validated treatment algorithms. In such cases, proposed resource investment, in the opinion of the investigators, would not contribute to further advancement of knowledge
```

## Locations (1)

- National Institutes of Health Clinical Center, Bethesda, Maryland, United States _(38.9807, -77.1003)_
  - For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) — (CONTACT) — 800-411-1222 — ccopr@nih.gov

## Central Contacts

- Surgical Neurology Branch — (CONTACT) — (301) 496-2921 — snbrecruiting@nih.gov

---

*Canonical: https://parkinsonspathways.com/trial/NCT00060541*  
*HTML version: https://parkinsonspathways.com/trial/NCT00060541*  
*Source data: https://clinicaltrials.gov/study/NCT00060541*