---
title: Brain stimulation improves stopping movements
nct_id: NCT04061135
phase: NA
status: RECRUITING
sponsor: University of Alabama at Birmingham
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT04061135"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04061135"
last_fetched: "2026-05-10T14:08:09.816Z"
source: "Parkinson's Pathways (curated)"
---
# Brain stimulation improves stopping movements

**Goal (in five words):** Brain stimulation improves stopping movements

**Official Title:** Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

**Trial ID:** [NCT04061135](https://clinicaltrials.gov/study/NCT04061135)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Alabama at Birmingham
- **Target Enrollment:** 90 participants
- **Start Date:** 2019-09-01
- **Completion Date:** 2028-03-31
- **Conditions:** Movement Disorders
- **Interventions:** Response Inhibition and Deep Brain Stimulation in Parkinson's disease
- **Intervention Types:** PROCEDURE

## Summary For Families

They want to map how deep brain stimulation changes the brain networks that control stopping or changing movements, like response inhibition, and how those changes relate to behavior and thinking in Parkinson's disease and essential tremor. People having DBS surgery will perform response inhibition tasks while researchers record brain activity and test how the implanted device's electrical pulses alter those signals and task performance; DBS delivers targeted electrical stimulation to deep brain regions to reduce motor symptoms and can modulate cognitive control circuits. Adults 18 and older with Parkinson's disease or essential tremor who are judged suitable for DBS surgery and can give informed consent and take part in the testing are eligible, while people who are not surgical candidates, cannot consent, are pregnant, or have not tried conservative medical management are excluded.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Eligible for DBS surgery based on multi-disciplinary consensus review
* Have a diagnosis of Parkinson's disease or Essential Tremor
* A minimum of 18 years of age
* Willingness to participate in the paradigms described in the protocol

Exclusion Criteria:

* Inability to provide full and informed consent
* Are not surgical candidates due to co-morbid conditions or pregnancy
* Have not undergone an adequate trial of conservative medical management
* Have a clinical presentation for which DBS surgery is not indicated
* Are not able to participate in study-related activities
```

## Locations (1)

- University of Alabama at Birmingham, Birmingham, Alabama, United States _(33.5207, -86.8025)_
  - Nicole Bentley, MD — (CONTACT) — 205-975-0011 — jbentley@uabmc.edu

## Central Contacts

- Nicole Bentley, MD — (CONTACT) — 205-975-0011 — jbentley@uabmc.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT04061135*  
*HTML version: https://parkinsonspathways.com/trial/NCT04061135*  
*Source data: https://clinicaltrials.gov/study/NCT04061135*