---
title: Improve ability to stop actions
nct_id: NCT04735458
phase: NA
status: RECRUITING
sponsor: University of Alabama at Birmingham
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT04735458"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04735458"
last_fetched: "2026-05-10T14:05:59.516Z"
source: "Parkinson's Pathways (curated)"
---
# Improve ability to stop actions

**Goal (in five words):** Improve ability to stop actions

**Official Title:** Investigating Inhibitory Control Networks in Parkinson's Disease

**Trial ID:** [NCT04735458](https://clinicaltrials.gov/study/NCT04735458)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Alabama at Birmingham
- **Target Enrollment:** 140 participants
- **Start Date:** 2021-04-01
- **Completion Date:** 2027-03-31
- **Conditions:** Parkinson Disease
- **Interventions:** Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
- **Intervention Types:** OTHER

## Summary For Families

The goal is to map and modulate the brain circuits that let you stop or control movements, so researchers can better understand why people with Parkinson's have trouble with response inhibition and impulsive actions. The approach uses deep brain stimulation, implanting electrodes to deliver targeted electrical pulses while participants do behavioral stopping tasks and have brain signals recorded, so the team can see how DBS changes the neural activity that halts actions; DBS alters abnormal circuit activity and can also change how symptoms respond to levodopa, sometimes allowing medication adjustments. The study is looking for adults 18 and older who are judged eligible for movement‑disorder surgery with Parkinson's disease, essential tremor, or another medically‑refractory movement disorder and who can give informed consent and participate in the protocol. People with prior stroke, brain hemorrhage, seizures, or who cannot complete study activities are excluded.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Eligible for surgery based on multi-disciplinary consensus review
* Have a diagnosis of Parkinson's disease or Essential Tremor
* Have a diagnosis of medically-refractory movement disorder (Parkinson's disease, Essential Tremor, or dystonia)
* Willingness to participate in the paradigms described in the protocol

Exclusion Criteria:

* Inability to provide full and informed consent
* Age younger than 18
* Are not able to participate in study-related activities
* History of prior ischemic/hemorrhagic stroke, subdural hemorrhage, or seizure
```

## Locations (1)

- University of Alabama at Birmingham, Birmingham, Alabama, United States _(33.5207, -86.8025)_
  - Nicole Bentley, MD — (CONTACT) — 205-975-0011 — jbentley@uabmc.edu

## Central Contacts

- Nicole Bentley, MD — (CONTACT) — 205-975-0011 — jbentley@uabmc.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT04735458*  
*HTML version: https://parkinsonspathways.com/trial/NCT04735458*  
*Source data: https://clinicaltrials.gov/study/NCT04735458*