---
title: Use spinal fluid to diagnose
nct_id: NCT04844060
status: RECRUITING
sponsor: University Hospital, Strasbourg, France
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT04844060"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04844060"
last_fetched: "2026-05-10T14:04:33.616Z"
source: "Parkinson's Pathways (curated)"
---
# Use spinal fluid to diagnose

**Goal (in five words):** Use spinal fluid to diagnose

**Official Title:** Analysis of Clinical Data and Diagnosis in Any Person Requiring an Assay of Alzheimer Biomarkers in Cerebrospinal Fluid

**Trial ID:** [NCT04844060](https://clinicaltrials.gov/study/NCT04844060)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** University Hospital, Strasbourg, France
- **Target Enrollment:** 10000 participants
- **Start Date:** 2010-02
- **Completion Date:** 2030-12
- **Conditions:** Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Parkinson's Disease Dementia, Multiple System Atrophy
- **Interventions:** Lumbar punction
- **Intervention Types:** OTHER

## Summary For Families

The goal is to see how Alzheimer-related proteins in spinal fluid relate to clinical diagnoses across different brain diseases, including Parkinson's disease dementia, so clinicians can tell which condition is most likely causing symptoms. Participants have a lumbar puncture to collect cerebrospinal fluid, which is tested for biomarkers like amyloid beta, total tau, and phosphorylated tau, and those lab results are compared with clinical information to improve diagnostic accuracy. This is an observational data-gathering effort, not a treatment, so it does not change medications like levodopa. Anyone of any age or sex who is having a lumbar puncture and has reliable clinical diagnostic information can be included.

## Eligibility

- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Patients with lumbar puncture (LP)
* Patients with accurate clinical diagnosis

Exclusion Criteria:

* Patients who do not have a lumbar puncture
* Patients for whom no accurate diagnostic information is available
```

## Locations (1)

- Service d'évaluation et Centre Mémoire de Ressources et de Recherche (CM2R), Hôpital de jour Saint François - Pôle de Gériatrie, Hôpitaux Universitaires de Strasbourg, Hôpital de la Robertsau, Strasbourg, France _(48.5839, 7.7455)_
  - Frédéric BLANC, MD/PhD — (CONTACT) — 33388115624 — frédéric.blanc@chru-strasbourg.fr
  - Olivier BOUSIGES, PharmaD/PhD — (CONTACT) — 33388128909 — olivier.bousiges@chru-strasbourg.fr

## Central Contacts

- Frédéric BLANC, MD/PhD — (CONTACT) — 33388155858 — frederic.blanc@unistra.fr
- Olivier BOUSIGES, PharmD/PhD — (CONTACT) — 33388128909 / 33368854039 — olivier.bousiges@chru-strasbourg.fr

---

*Canonical: https://parkinsonspathways.com/trial/NCT04844060*  
*HTML version: https://parkinsonspathways.com/trial/NCT04844060*  
*Source data: https://clinicaltrials.gov/study/NCT04844060*