---
title: Measure cognitive decline in Parkinsons
nct_id: NCT04997642
status: RECRUITING
sponsor: University of Pennsylvania
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT04997642"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04997642"
last_fetched: "2026-05-10T14:06:59.416Z"
source: "Parkinson's Pathways (curated)"
---
# Measure cognitive decline in Parkinsons

**Goal (in five words):** Measure cognitive decline in Parkinsons

**Official Title:** Parkinson's Disease and Movement Disorders Clinical Database

**Trial ID:** [NCT04997642](https://clinicaltrials.gov/study/NCT04997642)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** University of Pennsylvania
- **Target Enrollment:** 250 participants
- **Start Date:** 2019-09-30
- **Completion Date:** 2029-09-15
- **Conditions:** Parkinson Disease, Parkinson Disease Dementia, Lewy Body Parkinson Disease, Lewy Body Dementia With Behavioral Disturbance
- **Interventions:** neuropsychiatric and cognitive testing questionnaires
- **Intervention Types:** BEHAVIORAL

## Summary For Families

The goal is to build a clinical database to better understand how thinking, memory and neuropsychiatric symptoms change over time in Parkinson's and related Lewy body disorders, so researchers can spot patterns and design better care and trials. Participants complete standardized cognitive tests and neuropsychiatric questionnaires about mood, behavior and daily thinking during routine visits, and those data are collected and tracked over time; this is observational, not a treatment trial. The database plans to enroll about 250 people. Adults 18 and older with a Parkinson's diagnosis who have mild cognitive impairment or dementia and who can complete the assessments are eligible, with no age or disease severity limits beyond the ability to participate.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Any person who receives medical care for the diagnosis of Parkinson's disease with mild cognitive impairment (MCI) or dementia may be eligible to participate in the research database. There are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments.

Exclusion Criteria:

Absence of Parkinson's disease diagnosis. There are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments.
```

## Locations (1)

- University of Pennsylvania, Philadelphia, Pennsylvania, United States _(39.9524, -75.1636)_
  - Sarah Shaw — (CONTACT) — 215-615-0838 — sarah.shaw@pennmedicine.upenn.edu
  - Gina Mamikonyan — (CONTACT) — 215-615-3085 — eugeniam@pennmedicine.upenn.edu

## Central Contacts

- Eugenia Mamikonyan — (CONTACT) — 215-615-3085 — eugenia.mamikonyan@pennmedicine.upenn.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT04997642*  
*HTML version: https://parkinsonspathways.com/trial/NCT04997642*  
*Source data: https://clinicaltrials.gov/study/NCT04997642*