---
title: Reduce freezing with dynamic cycling
nct_id: NCT05298150
phase: NA
status: RECRUITING
sponsor: VA Office of Research and Development
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05298150"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05298150"
last_fetched: "2026-05-10T14:03:26.916Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce freezing with dynamic cycling

**Goal (in five words):** Reduce freezing with dynamic cycling

**Official Title:** Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease

**Trial ID:** [NCT05298150](https://clinicaltrials.gov/study/NCT05298150)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** VA Office of Research and Development
- **Target Enrollment:** 72 participants
- **Start Date:** 2022-04-01
- **Completion Date:** 2026-03-31
- **Conditions:** Parkinson's Disease
- **Interventions:** Dynamic cycling, Forced cycling
- **Intervention Types:** OTHER

## Summary For Families

The goal is to test whether remote dynamic or forced cycling can improve motor function and mobility in Parkinson's, especially slowness and walking difficulties. The approach uses a motor-assisted bicycle that moves your legs at a faster, steady cadence than you could produce on your own, a pattern thought to help retrain motor circuits and boost movement control, with sessions done off-site and monitored remotely. It is meant to be used alongside your usual Parkinson's medications, not as a replacement, so participants must be on a stable antiparkinsonian regimen for at least six months. The study is enrolling adults 18 and older with mild to moderate Parkinson's, Hoehn and Yahr stages I to III off medication, who have enough cognition to consent (MoCA 18 or higher) and no significant untreated cardiovascular issues, severe depression, anxiety, or atypical parkinsonism.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Diagnosis of PD using the UK Brain Bank criteria

* Ability to perform informed consent.
* Hoehn and Yahr (H\&Y) stages I-III when off medication,
* Stable medical regimen of antiparkinsonian medication for at least six months

Exclusion Criteria:

* Montreal Cognitive Assessment Scoreless than 18
* Hamilton depression score of 20 or higher
* Hamilton anxiety rating score greater than 24
* Clinical diagnosis including perinatal brain injury, stroke, and atypical parkinsonism
* One or more signs or symptoms of untreated cardiovascular disease including Pain, discomfort in the chest, neck, jaw, arms or other areas that may result from ischemia - Shortness of breath at rest or with mild exertion - Dizziness or syncope - Orthopnea or paroxysmal nocturnal dyspnea - Ankle edema - Palpitations or tachycardia - Intermittent claudication - heart murmur - Unusual fatigue or shortness of breath with usual activity (ACSM Cardiovascular Risk Assessment)
```

## Locations (1)

- Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio, United States _(41.4995, -81.6954)_
  - Holly B Henry — (CONTACT) — 216-791-3800 — holly.henry@va.gov
  - Aasef G. Shaikh, MD PhD — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Aasef G Shaikh, MD PhD — (CONTACT) — (216) 791-3800 — Aasef.Shaikh@va.gov
- Varun Sundaram, MBBS PhD — (CONTACT) — (216) 679-3800 — varun.sundaram@va.gov

---

*Canonical: https://parkinsonspathways.com/trial/NCT05298150*  
*HTML version: https://parkinsonspathways.com/trial/NCT05298150*  
*Source data: https://clinicaltrials.gov/study/NCT05298150*