---
title: Track movement disorder symptom progression
nct_id: NCT05413291
status: RECRUITING
sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05413291"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05413291"
last_fetched: "2026-05-10T14:02:24.116Z"
source: "Parkinson's Pathways (curated)"
---
# Track movement disorder symptom progression

**Goal (in five words):** Track movement disorder symptom progression

**Official Title:** Natural History Protocol for Movement Disorders

**Trial ID:** [NCT05413291](https://clinicaltrials.gov/study/NCT05413291)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** National Institute of Neurological Disorders and Stroke (NINDS)
- **Target Enrollment:** 4000 participants
- **Start Date:** 2022-10-17
- **Completion Date:** 2030-12-31
- **Conditions:** Movement Disorder, Tremor, Parkinson's Disease

## Summary For Families

The goal is to map the natural history of movement disorders like Parkinson's and tremor, so researchers can see how symptoms and biological markers change over time and build better tests and treatments. The approach is observational, following participants with regular clinical assessments and data collection, which can include symptom ratings, medical history, and possibly imaging or biological samples to identify patterns and biomarkers. Anyone aged 2 and older who has or is suspected to have a movement disorder, or a family member of someone with a suspected disorder, and who can give consent or has a legally authorized representative can join, children under 2 are excluded.

## Eligibility

- **Minimum age:** 2 Years
- **Maximum age:** 100 Years
- **Sex:** ALL

### Full Criteria

```
* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

* Stated willingness to comply with all study procedures and availability for the duration of the study
* Male or female, aged 2 and above
* Either one of these:

  * Have or suspected to have a diagnosis of a movement disorder.
  * Family member of someone who has or is suspected of having a diagnosis of a movement disorder.
* Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

An individual who meets the following criteria will be excluded from participation in this study:

-Being \< 2 years old.
```

## Locations (1)

- National Institutes of Health Clinical Center, Bethesda, Maryland, United States _(38.9807, -77.1003)_
  - For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) — (CONTACT) — 800-411-1222 — ccopr@nih.gov

## Central Contacts

- Vivian S Koo — (CONTACT) — (301) 435-8518 — vivian.koo@nih.gov
- Debra J Ehrlich, M.D. — (CONTACT) — (301) 443-7888 — debra.ehrlich@nih.gov

---

*Canonical: https://parkinsonspathways.com/trial/NCT05413291*  
*HTML version: https://parkinsonspathways.com/trial/NCT05413291*  
*Source data: https://clinicaltrials.gov/study/NCT05413291*