---
title: Reduce on off motor swings
nct_id: NCT05471609
phase: EARLY_PHASE1
status: RECRUITING
sponsor: University of Minnesota
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05471609"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05471609"
last_fetched: "2026-05-10T14:07:52.016Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce on off motor swings

**Goal (in five words):** Reduce on off motor swings

**Official Title:** Sustained Release Oral Formulation for Treatment of Parkinson's Disease

**Trial ID:** [NCT05471609](https://clinicaltrials.gov/study/NCT05471609)

## Key Facts

- **Phase:** EARLY_PHASE1
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Minnesota
- **Target Enrollment:** 6 participants
- **Start Date:** 2025-06-12
- **Completion Date:** 2026-06-16
- **Conditions:** Healthy Volunteers
- **Interventions:** levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B
- **Intervention Types:** DRUG

## Summary For Families

Goal: test whether sustained-release oral levodopa/carbidopa can keep levodopa levels more steady, which could help reduce the on/off motor swings people with Parkinson's get with standard levodopa dosing. Approach: two experimental sustained-release formulations, A and B, are being given to healthy volunteers to look at safety and how the body absorbs and clears the drug; the pills release levodopa more slowly and include carbidopa to prevent early breakdown so more levodopa reaches the brain. Eligibility: healthy adults 18 to 65 who are not on regular medications, can fast for six hours, and are not pregnant.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 65 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Normal healthy
* Are 18-65 years of age
* Are not currently taking medications regularly
* Able to fast 6 hours (water allowed)

Exclusion Criteria:

* Pregnancy
* Inability to fast
```

## Locations (1)

- University of Minnesota, Minneapolis, Minnesota, United States _(44.9800, -93.2638)_
  - Research Coordinator — (CONTACT) — 507-339-4093 — umnstudies@gmail.com

## Central Contacts

- Research Coordinator — (CONTACT) — 507-339-4093 — umnstudies@gmail.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT05471609*  
*HTML version: https://parkinsonspathways.com/trial/NCT05471609*  
*Source data: https://clinicaltrials.gov/study/NCT05471609*