---
title: Find drugs boosting cell cleanup
nct_id: NCT05536388
status: RECRUITING
sponsor: New York Stem Cell Foundation Research Institute
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05536388"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05536388"
last_fetched: "2026-05-10T14:05:48.116Z"
source: "Parkinson's Pathways (curated)"
---
# Find drugs boosting cell cleanup

**Goal (in five words):** Find drugs boosting cell cleanup

**Official Title:** Drug Discovery for Parkinson's With Mutations in the GBA Gene

**Trial ID:** [NCT05536388](https://clinicaltrials.gov/study/NCT05536388)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** New York Stem Cell Foundation Research Institute
- **Target Enrollment:** 60 participants
- **Start Date:** 2022-07-15
- **Completion Date:** 2025-07-15
- **Conditions:** Parkinson Disease, Gaucher Disease, Healthy, GBA Gene Mutation
- **Interventions:** Biological Sample Collection
- **Intervention Types:** OTHER

## Summary For Families

The goal is to speed discovery of drugs for people whose Parkinson's is linked to mutations in the GBA gene, which increases risk by weakening an enzyme called glucocerebrosidase and impairing the cell’s cleanup system, the lysosome. Researchers collect blood and skin samples to grow patients' cells in the lab, study how GBA mutations harm cell health, and screen compounds that might boost the enzyme or improve lysosomal function. Adults 18 and older with Parkinson's, people with Gaucher disease, and healthy volunteers can join if they can consent; people with bleeding disorders, a history of keloids for skin biopsies, allergy to local anesthetic, contraindicating anticoagulation, or AIDS with very low CD4 counts are excluded.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Age 18 years or older.
* Diagnosis of Parkinson's disease, Gaucher disease, or healthy control.
* Must provide written informed consent unless physical limitations preclude signing.

Exclusion Criteria:

* For skin samples collected specifically for this study: history of keloid formation, coagulation disorder, allergy to the anesthetic, or anticoagulation use that precludes sample collection.
* For blood samples collected specifically for this study: coagulation disorder or other medical condition(s) that increases the risks associated with blood collection.
* For all prospective sample collections: Subjects who refuse to adhere to NYSCF's and/or a collection site's safety protocols will be excluded. Subjects with an AIDS diagnosis and CD4 count of less than 200 cells per microliter (mcL) of blood will be excluded due to increased risk of infection.
```

## Locations (1)

- The New York Stem Cell Foundation Research Institute, New York, New York, United States _(40.7143, -74.0060)_
  - Clinical Research Office — (CONTACT) — 212-927-1801 — clinicalresearch@nyscf.org
  - Laura Andres-Martin — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Clinical Research Office — (CONTACT) — 212-927-1801 — clinicalresearch@nyscf.org

---

*Canonical: https://parkinsonspathways.com/trial/NCT05536388*  
*HTML version: https://parkinsonspathways.com/trial/NCT05536388*  
*Source data: https://clinicaltrials.gov/study/NCT05536388*