---
title: Improve electrode placement during surgery
nct_id: NCT05550714
phase: NA
status: RECRUITING
sponsor: Beijing Tiantan Hospital
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05550714"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05550714"
last_fetched: "2026-05-10T14:06:32.316Z"
source: "Parkinson's Pathways (curated)"
---
# Improve electrode placement during surgery

**Goal (in five words):** Improve electrode placement during surgery

**Official Title:** Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease (CHAMPION)：A Randomized Controlled, Non-Inferiority Study

**Trial ID:** [NCT05550714](https://clinicaltrials.gov/study/NCT05550714)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Beijing Tiantan Hospital
- **Target Enrollment:** 188 participants
- **Start Date:** 2022-10-15
- **Completion Date:** 2024-03-26
- **Conditions:** PD - Parkinson's Disease, Dexmedetomidine, Desflurane, Deep Brain Stimulation
- **Interventions:** general anesthesia, Conscious sedation
- **Intervention Types:** DRUG

## Summary For Families

It aims to find out whether using general anesthesia with desflurane is no worse than conscious sedation with dexmedetomidine during the microelectrode recording step of bilateral subthalamic nucleus DBS, looking at the quality of brain signals, accuracy of electrode placement, and patient safety and comfort. One approach gives full inhaled anesthesia with desflurane, which puts patients fully asleep but can dampen the neural signals surgeons use for mapping, the other uses dexmedetomidine for lighter, cooperative sedation that preserves breathing and allows surgeons to test responses during surgery. The trial is enrolling people aged 50 to 80 having bilateral STN-DBS with ASA physical status II or III who can give consent. People with obstructive sleep apnea, BMI over 30, predicted difficult airways, severe preoperative anxiety, major organ failure, or allergies to the anesthetics are not eligible.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

1.50-80 years old, ASA grade II-III; 2.Bilateral STN-DBS of patients with Parkinson's disease; 3.Signed informed consent.

Exclusion Criteria:

1. Obstructive sleep apnea;
2. BMI \> 30kg/m2;
3. Estimated difficult airway;
4. Severe preoperative anxiety;
5. Serious dysfunction of important organs (i.e. heart failure, renal or liver dysfunction)
6. A history of allergy to the anaesthetics.
```

## Locations (1)

- Beijing Tiantan Hospital, Capital Medical University, Beijing, China _(39.9075, 116.3972)_
  - Ruquan Han, M.D., Ph.D — (CONTACT) — 8610-59976660 — ruquan.han@gmail.com
  - Ruquan Han, M.D., Ph.D — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Ruquan Han, MD, PhD — (CONTACT) — 8610-59976660 — ruquan.han@gmail.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT05550714*  
*HTML version: https://parkinsonspathways.com/trial/NCT05550714*  
*Source data: https://clinicaltrials.gov/study/NCT05550714*