---
title: Reduce tremor stiffness and slowness
nct_id: NCT05557864
phase: NA
status: RECRUITING
sponsor: University of Minnesota
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05557864"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05557864"
last_fetched: "2026-05-10T14:08:27.116Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce tremor stiffness and slowness

**Goal (in five words):** Reduce tremor stiffness and slowness

**Official Title:** Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

**Trial ID:** [NCT05557864](https://clinicaltrials.gov/study/NCT05557864)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Minnesota
- **Target Enrollment:** 24 participants
- **Start Date:** 2016-08-25
- **Completion Date:** 2026-12-31
- **Conditions:** Parkinson's Disease
- **Interventions:** Deep Brain Stimulation
- **Intervention Types:** DEVICE

## Summary For Families

The team wants to know whether the exact location of deep brain stimulation in the globus pallidus versus the subthalamic nucleus changes how much motor symptoms like tremor, stiffness, and slowness improve. They use the already implanted DBS devices to deliver continuous electrical pulses that modulate overactive brain circuits, they map electrode positions on high-resolution 7T MRI and relate location to motor benefit, and DBS can often reduce symptoms and sometimes allow lower levodopa doses or change medication response. Adults 21 to 89 with idiopathic Parkinson's who already have GP or STN DBS and existing 7T imaging are eligible, while people with major musculoskeletal or other neurologic disorders, dementia, or post-operative complications are excluded.

## Eligibility

- **Minimum age:** 21 Years
- **Maximum age:** 89 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* diagnosis of idiopathic PD
* have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
* Existing 7T brain imagery

Exclusion Criteria:

* history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
* other significant neurological disorder
* history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
* post-operative complications or adverse effects
```

## Locations (1)

- University Of Minnesota, Minneapolis, Minnesota, United States _(44.9800, -93.2638)_
  - Colum MacKinnon, PhD — (CONTACT) — cmackinn@umn.edu

## Central Contacts

- Colum MacKinnon, PhD — (CONTACT) — cmackinn@umn.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT05557864*  
*HTML version: https://parkinsonspathways.com/trial/NCT05557864*  
*Source data: https://clinicaltrials.gov/study/NCT05557864*