---
title: Improve sleep quality through exercise
nct_id: NCT05644327
phase: NA
status: RECRUITING
sponsor: McGill University
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05644327"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05644327"
last_fetched: "2026-05-10T14:07:39.716Z"
source: "Parkinson's Pathways (curated)"
---
# Improve sleep quality through exercise

**Goal (in five words):** Improve sleep quality through exercise

**Official Title:** The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease

**Trial ID:** [NCT05644327](https://clinicaltrials.gov/study/NCT05644327)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** McGill University
- **Target Enrollment:** 150 participants
- **Start Date:** 2021-09-01
- **Completion Date:** 2027-12-30
- **Conditions:** Parkinson Disease
- **Interventions:** Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- **Intervention Types:** BEHAVIORAL

## Summary For Families

They want to find which kind of exercise best improves sleep quality and the makeup of sleep in people with Parkinson's, for example increasing deep restorative sleep and cutting down nighttime awakenings. Participants are assigned to cardiovascular training, resistance training, or a combined program, with cardio raising heart rate and aerobic fitness to strengthen circadian cues and slow wave sleep, resistance work building muscle to reduce nighttime stiffness and sleep disruption, and the combined approach doing both. Exercise here is a nonpharmacologic complement to medications like levodopa; it does not change how levodopa works but may lessen nocturnal motor symptoms and improve sleep without adding drug side effects. The trial seeks adults 40 and over with mild to moderate idiopathic Parkinson's (Hoehn and Yahr 0.5,3.5), on stable meds and reporting poor sleep (PDSS-2 >15), while excluding people with dementia, severe untreated sleep apnea, major cognitive or depressive impairment, serious exercise contraindications, or who are already highly active.

## Eligibility

- **Minimum age:** 40 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5);
* On a stable dosage of medication during the previous month;
* Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;

Exclusion Criteria:

* Having atypical parkinsonism, dementia, stroke, or any other neurological condition;
* Presenting severe untreated obstructive sleep apnea (OSA);
* Having a Montreal Cognitive Assessment (MoCA) score \<18
* Having a Beck Depression Inventory score \>31;
* Having absolute contraindications to exercise;
* Having severe osteoporosis;
* Participating in an exercise or drug trial during the period of the study;
* Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.
```

## Locations (3)

- Jewish Rehabilitation Hospital, Laval, Quebec, Canada _(45.5699, -73.6920)_
  - Marc Roig, Ph.D. — (CONTACT) — 450-688-9550 — marc.roigpull@mcgill.ca
  - Jacopo Cristini, MSc — (CONTACT) — 450-688-9550 — jacopo.cristini@mail.mcgill.ca
- Human Brain Control of Locomotion Laboratory, Montreal, Quebec, Canada _(45.5088, -73.5878)_
  - Caroline Paquette, Ph.D. — (CONTACT) — 514-398-4400 — caroline.paquette@mcgill.ca
  - Alexandra Potvin-Desrochers, Ph.D. — (CONTACT) — 514-398-4184 — alexandra.potvin-desrochers@mail.mcgill.ca
- Cummings Centre, Montreal, Quebec, Canada _(45.5088, -73.5878)_
  - Maria Fragapane — (CONTACT) — 514.734.1797 — maria.fragapane@cummingscentre.org

## Central Contacts

- Marc Roig, Ph.D. — (CONTACT) — 514-398-4400 — marc.roigpull@mcgill.ca
- Caroline Paquette, Ph.D. — (CONTACT) — 514-398-4400 — caroline.paquette@mcgill.ca

---

*Canonical: https://parkinsonspathways.com/trial/NCT05644327*  
*HTML version: https://parkinsonspathways.com/trial/NCT05644327*  
*Source data: https://clinicaltrials.gov/study/NCT05644327*