---
title: Targeted brain stimulation reduces tremor
nct_id: NCT05658302
status: RECRUITING
sponsor: University of Minnesota
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05658302"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05658302"
last_fetched: "2026-05-10T14:06:11.316Z"
source: "Parkinson's Pathways (curated)"
---
# Targeted brain stimulation reduces tremor

**Goal (in five words):** Targeted brain stimulation reduces tremor

**Official Title:** Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

**Trial ID:** [NCT05658302](https://clinicaltrials.gov/study/NCT05658302)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** University of Minnesota
- **Target Enrollment:** 30 participants
- **Start Date:** 2023-03-28
- **Completion Date:** 2027-03-01
- **Conditions:** Parkinson Disease

## Summary For Families

The goal is to map and use specific brain circuits to make deep brain stimulation more precise and effective for Parkinson's motor symptoms, so stimulation can reduce tremor, slowness, and stiffness while limiting side effects. The approach is observational: patients having routine DBS at the University of Minnesota will receive directional leads and a programmable implantable pulse generator with multiple independent current control, DBS delivers small electrical pulses to motor circuits, directional leads steer current toward helpful areas and independent current control shapes stimulation across contacts, and the protocol may include intraoperative recordings such as an ECoG strip. Looking for adults 21 and older with idiopathic Parkinson's who plan DBS surgery at UMN with those devices, people with other major neurological disorders, dementia, pregnancy, recent unsafe radiation exposure, or post-op complications that affect safety are excluded.

## Eligibility

- **Minimum age:** 21 Years
- **Sex:** FEMALE

### Full Criteria

```
Inclusion Criteria:

* Diagnosis of idiopathic PD
* Surgery at UMN to implant DBS system with directional lead(s) and multiple independent current control IPG is planned as part of routine clinical care
* At least 21 years old

Exclusion Criteria:

* Other significant neurological disorder
* History of dementia
* Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
* Pregnant women
* Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip
```

## Locations (1)

- University Of Minnesota, Minneapolis, Minnesota, United States _(44.9800, -93.2638)_
  - Michael Park, MD, PhD — (CONTACT)

## Central Contacts

- Emily Weatherill — (CONTACT) — 612-625-4947 — weath210@umn.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT05658302*  
*HTML version: https://parkinsonspathways.com/trial/NCT05658302*  
*Source data: https://clinicaltrials.gov/study/NCT05658302*