---
title: Reduce pain and autonomic symptoms
nct_id: NCT05748028
status: RECRUITING
sponsor: Istituti Clinici Scientifici Maugeri SpA
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05748028"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05748028"
last_fetched: "2026-05-10T14:07:57.016Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce pain and autonomic symptoms

**Goal (in five words):** Reduce pain and autonomic symptoms

**Official Title:** Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life

**Trial ID:** [NCT05748028](https://clinicaltrials.gov/study/NCT05748028)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Istituti Clinici Scientifici Maugeri SpA
- **Target Enrollment:** 280 participants
- **Start Date:** 2019-06-15
- **Completion Date:** 2026-09-30
- **Conditions:** Parkinson Disease, Multiple System Atrophy
- **Interventions:** Rehabilitation, Administration of Clinical scales
- **Intervention Types:** OTHER

## Summary For Families

The goal is to find which patterns of pain and autonomic symptoms, like dizziness when standing, constipation, urinary problems, or abnormal sweating, predict who will get the most benefit from rehabilitation and how those symptoms shape quality of life for people with Parkinson's disease or multiple system atrophy. Participants take part in rehabilitation focused on improving mobility, reducing pain, and managing autonomic problems, while researchers use validated clinical scales to measure pain, orthostatic blood pressure changes, bowel and bladder symptoms, mood, and quality of life, then link those measures to rehab outcomes. The study is looking for adults 18 and older with a clinical diagnosis of Parkinson's disease or MSA and a Mini-Mental State Examination score of at least 10, and it excludes people with vascular or drug-induced parkinsonism, diabetes, major liver or kidney disorders, thyroid disease, or use of potentially neurotoxic drugs.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Clinical diagnosis of Parkinson's Disease or Multiple System Atrophy according to current international criteria (Gilman S et al, 2008; Postuma RB et al. 2015).
* Mini-Mental State Examination score at least 10

Exclusion Criteria:

* vascular or pharmacological parkinsonism
* diabetes mellitus
* hepatic or renal dysmetabolism,
* hypothyroidism or hyperthyroidism
* assumption of potentially neurotoxic drugs
```

## Locations (9)

- ICS Maugeri - IRCCS of Telese Terme, Telese Terme, Benevento, Italy _(41.2175, 14.5268)_
  - Vincenzo Provitera, MD — (CONTACT) — +390824909257 — vincenzo.provitera@icsmaugeri.it
- ICS Maugeri - Lumezzane, Lumezzane, Brescia, Italy _(45.6479, 10.2649)_
  - Diego Ghianda, MD — (CONTACT) — 0308253186 — diego.ghianda@icsmaugeri.it
- ICS Maugeri - Castelgoffredo, Castel Goffredo, Mantova, Italy _(45.2940, 10.4730)_
  - Giuliana Vezzadini, MD — (CONTACT) — 037677471 — giuliana.vezzadini@icsmaugeri.it
- ICS Maugeri - Mistretta, Mistretta, Messina, Italy _(37.9282, 14.3578)_
  - Paolo Volanti, MD — (CONTACT) — 0921389574 — paolo.volanti@icsmaugeri.it
- ICS Maugeri - Veruno, Veruno, Novara, Italy _(45.6889, 8.5286)_
  - Giorgio Maggioni, MD — (CONTACT) — 0322884711 — giorgio.maggioni@icsmaugeri.it
- ICS Maugeri - Montescano, Montescano, Pavia, Italy _(45.0320, 9.2837)_
  - Cira Fundarò, MD — (CONTACT) — 0385247268 — cira.fundaro@icsmaugeri.it
- ICS Maugeri - Milano, Milan, Italy _(42.7824, 12.5984)_
  - Beatrice De Maria, Eng — (CONTACT) — 0250725260 — beatrice.demaria@icsmaugeri.it
- ICS Maugeri - Pavia Boezio, Pavia, Italy _(45.1921, 9.1592)_
  - Marianna Loi, MD — (CONTACT) — +3903825931 — marianna.loi@icsmaugeri.it
- ICS Maugeri - Pavia, Pavia, Italy _(45.1921, 9.1592)_
  - Isabella Springhetti, MD — (CONTACT) — +390382592621 — isabella.springhetti@icsmaugeri.it

## Central Contacts

- Maria Nolano, MD, PhD — (CONTACT) — +390824909257 — maria.nolano@icsmaugeri.it
- Giuseppe Caporaso — (CONTACT) — +390824909645 — giuseppe.caporaso@icsmaugeri.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT05748028*  
*HTML version: https://parkinsonspathways.com/trial/NCT05748028*  
*Source data: https://clinicaltrials.gov/study/NCT05748028*