---
title: Reduce tremor using brain stimulation
nct_id: NCT05752656
status: RECRUITING
sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05752656"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05752656"
last_fetched: "2026-05-10T14:03:10.016Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce tremor using brain stimulation

**Goal (in five words):** Reduce tremor using brain stimulation

**Official Title:** Short- and Long-term Behavioral, Cognitive and Motor Outcomes of Frameless Deep Brain Stimulation in Patients With Parkinson's Disease: a Prospective Observational Study

**Trial ID:** [NCT05752656](https://clinicaltrials.gov/study/NCT05752656)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- **Target Enrollment:** 100 participants
- **Start Date:** 2022-01-12
- **Completion Date:** 2023-12-01
- **Conditions:** Parkinson Disease
- **Interventions:** Clinical examinations
- **Intervention Types:** OTHER

## Summary For Families

The goal is to track short- and long-term motor, cognitive, and behavioral effects after frameless deep brain stimulation in people with Parkinson's. Frameless DBS uses image-guided, frame-free surgery to place electrodes that deliver continuous electrical pulses to deep brain targets, which can reduce tremor, stiffness, and slowness and may allow lowering levodopa doses while sometimes affecting mood or thinking; researchers will follow patients with regular clinical examinations to see how these areas change over time. The study is enrolling adults 18 and older with idiopathic Parkinson's who are already judged suitable for DBS under standard CAPSIT-PD criteria, excluding only those unable to give informed consent.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria;
* patients who are candidates for deep brain stimulation intervention, according to the international criteria of the "Core assessment program for surgical interventional therapies in Parkinson's disease" (CAPSIT-PD).

Exclusion Criteria:

\- patients unable to give informed consent.
```

## Locations (1)

- Flavia Torlizzi, Rome, Italy _(41.8919, 12.5113)_
  - Flavia Torlizzi — (CONTACT) — +390630156433 — flavia.torlizzi@policlinicogemelli.it

## Central Contacts

- Francesco Bove, MD — (CONTACT) — +390630156433 — francesco.bove@policlinicogemelli.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT05752656*  
*HTML version: https://parkinsonspathways.com/trial/NCT05752656*  
*Source data: https://clinicaltrials.gov/study/NCT05752656*