---
title: Improve sleep in Parkinson patients
nct_id: NCT05962489
phase: NA
status: RECRUITING
sponsor: University of Minnesota
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT05962489"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05962489"
last_fetched: "2026-05-10T14:02:40.516Z"
source: "Parkinson's Pathways (curated)"
---
# Improve sleep in Parkinson patients

**Goal (in five words):** Improve sleep in Parkinson patients

**Official Title:** Sleep-specific DBS Therapy in Parkinson's Disease

**Trial ID:** [NCT05962489](https://clinicaltrials.gov/study/NCT05962489)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Minnesota
- **Target Enrollment:** 64 participants
- **Start Date:** 2023-06-22
- **Completion Date:** 2027-08-01
- **Conditions:** Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia
- **Interventions:** Clinically optimized deep brain stimulation
- **Intervention Types:** OTHER

## Summary For Families

The goal is to improve sleep in people with Parkinson's by using deep brain stimulation that is specifically tuned to sleep states, so stimulation can better regulate the brain circuits that disrupt normal sleep. The approach implants directional DBS leads bilaterally in either the globus pallidus interna or subthalamic nucleus as part of routine surgical care at the University of Minnesota, uses 7T imaging and sleep-focused programming and recordings, and adjusts electrical pulses to modulate abnormal neural activity during sleep. Participants must be adults 21 or older with idiopathic Parkinson's who are planning or have had bilateral GPi or STN DBS with directional leads at UMN and can undergo the required imaging, while people with dementia, other major neurological disorders, pregnancy, recent unsafe radiation exposure, or certain post-op complications are excluded.

## Eligibility

- **Minimum age:** 21 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion criteria:

* Diagnosis of idiopathic PD
* At least 21 years old
* Existing or planned 7T brain imaging
* Surgery at UMN to implant DBS system in GPi or STN with directional lead(s) is planned as part of routine clinical care
* Surgery at UMN to implant bilateral DBS system in GPi or STN with directional lead(s) is planned as part of routine clinical care (or has already occurred, as long as the initial programming session is at least 2 weeks away)

Exclusion criteria:

* Other significant neurological disorder
* History of dementia
* Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
* Pregnant women
* Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip
```

## Locations (1)

- University Of Minnesota, Minneapolis, Minnesota, United States _(44.9800, -93.2638)_
  - Luke Johnson, PhD — (CONTACT) — 612-625-9900 — joh03032@umn.edu

## Central Contacts

- Emily Weatherill, BS — (CONTACT) — 612-625-4947 — weath210@umn.edu
- Luke Johnson, PhD — (CONTACT) — 612-625-9900 — joh03032@umn.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT05962489*  
*HTML version: https://parkinsonspathways.com/trial/NCT05962489*  
*Source data: https://clinicaltrials.gov/study/NCT05962489*