---
title: Reduce exertion with adaptive stimulation
nct_id: NCT06296810
status: RECRUITING
sponsor: University of Colorado, Denver
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06296810"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06296810"
last_fetched: "2026-05-10T14:04:34.816Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce exertion with adaptive stimulation

**Goal (in five words):** Reduce exertion with adaptive stimulation

**Official Title:** Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease

**Trial ID:** [NCT06296810](https://clinicaltrials.gov/study/NCT06296810)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** University of Colorado, Denver
- **Target Enrollment:** 10 participants
- **Start Date:** 2024-09-01
- **Completion Date:** 2025-12
- **Conditions:** Parkinson Disease
- **Interventions:** aDBS
- **Intervention Types:** DEVICE

## Summary For Families

The goal is to see if adaptive deep brain stimulation can prevent abnormal subthalamic nucleus activity during exercise, so people with Parkinson's feel less exertion and fatigue while moving. The approach uses your already‑implanted Medtronic Sensight leads and Percept IPG to sense STN signals and automatically adjust stimulation strength in real time, stabilizing motor signals during activity rather than relying on a fixed setting, and it is a device change that works alongside your current medications and DBS hardware. The study seeks 20 to 70 year olds who already have a Sensight implant with a Percept IPG, can complete the exercise testing, and can give informed consent, with about 10 people expected to enroll.

## Eligibility

- **Minimum age:** 20 Years
- **Maximum age:** 70 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.

\-

Exclusion Criteria:

Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
```

## Locations (1)

- University of Colorado, Aurora, Colorado, United States _(39.7294, -104.8319)_
  - Pamela David Gerecht, PhD — (CONTACT) — 303-724-4134 — pamela.davidgerecht@cuanschutz.edu
  - Drew Kern, MD — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Pamela David Gerecht, PhD — (CONTACT) — 303-724-4134 — pamela.davidgerecht@cuanschutz.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT06296810*  
*HTML version: https://parkinsonspathways.com/trial/NCT06296810*  
*Source data: https://clinicaltrials.gov/study/NCT06296810*