---
title: Brain stimulation effects on thinking
nct_id: NCT06329726
status: RECRUITING
sponsor: "Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico"
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06329726"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06329726"
last_fetched: "2026-05-10T14:06:36.745Z"
source: "Parkinson's Pathways (curated)"
---
# Brain stimulation effects on thinking

**Goal (in five words):** Brain stimulation effects on thinking

**Official Title:** Long-Term Behavioral and Cognitive Outcomes of Deep Brain Stimulation in Patients With Parkinson's Disease

**Trial ID:** [NCT06329726](https://clinicaltrials.gov/study/NCT06329726)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- **Target Enrollment:** 52 participants
- **Start Date:** 2021-12-13
- **Completion Date:** 2031-12-15
- **Conditions:** Parkinson Disease
- **Interventions:** Clinical examinations and clinical scales administration
- **Intervention Types:** DIAGNOSTIC_TEST

## Summary For Families

The goal is to track long-term behavioral and cognitive effects after subthalamic nucleus deep brain stimulation, and to compare those outcomes with people managed on best medical therapy. Participants have regular clinical exams and rating scales; DBS works by sending continuous electrical pulses to the subthalamic nucleus to normalize abnormal brain-circuit activity that causes motor symptoms, often letting people reduce levodopa doses, though it can also change mood, impulse control, and some aspects of thinking. The study is enrolling adults 18 to 70 who are either candidates for STN DBS or are on best medical treatment, excluding anyone unable to complete the assessments.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 70 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Parkinson's disease patients candidates for DBS of the subthalamic nucleus
* Parkinson's disease patients with best medical treatment

Exclusion Criteria:

* patients unable to complete study assessments
```

## Locations (1)

- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Lombardy, Italy _(45.4643, 9.1895)_
  - Eleonora Zirone, Dr — (CONTACT) — 0255038671 — eleonora.zirone@policlinico.mi.it

## Central Contacts

- Fabiana Ruggiero, Dr — (CONTACT) — 0255033621 — fabiana.ruggiero@policlinico.mi.it
- Eleonora Zirone, Dr — (CONTACT) — 0255038671 — eleonora.zirone@policlinico.mi.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT06329726*  
*HTML version: https://parkinsonspathways.com/trial/NCT06329726*  
*Source data: https://clinicaltrials.gov/study/NCT06329726*