---
title: Detect Parkinson using breath microbiome
nct_id: NCT06453226
status: RECRUITING
sponsor: Imperial College London
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06453226"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06453226"
last_fetched: "2026-05-10T14:07:59.950Z"
source: "Parkinson's Pathways (curated)"
---
# Detect Parkinson using breath microbiome

**Goal (in five words):** Detect Parkinson using breath microbiome

**Official Title:** PArkinson's Non-Invasive Volatile ORganic Compound Analysis and Microbiome Assessment (PANORAMA) Study

**Trial ID:** [NCT06453226](https://clinicaltrials.gov/study/NCT06453226)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Imperial College London
- **Target Enrollment:** 120 participants
- **Start Date:** 2023-01-25
- **Completion Date:** 2024-06-30
- **Conditions:** Parkinson Disease

## Summary For Families

PANORAMA aims to find noninvasive signals in breath and stool that could help detect or track Parkinson's by spotting volatile organic compounds and gut microbiome patterns linked to the disease. The approach is to collect breath samples to measure volatile organic compounds, which are metabolic byproducts from the body and microbes that can change with illness, and stool samples for microbiome sequencing to see how bacterial communities differ in Parkinson's; no drugs or treatments are given. The study is enrolling adults 18 to 90, both people with confirmed or suspected Parkinson's who are having neurological assessment and healthy volunteers including partners or carers, and participants must be off antibiotics or probiotics for at least four weeks, have no diagnosed dysbiotic conditions, and be able to consent.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 90 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria \[PD group\]:

* (i) Patients undergoing neurological examination for confirmed or suspected Parkinson's disease
* (ii) Patients aged ≥18 years and below 90 years of age;
* (iii) Patients off antibiotic or probiotic therapies for at least the last 4 weeks;
* (iv) Patients without formal diagnosis of dysbiotic conditions;
* (v) Patients with capacity.

Inclusion Criteria \[Healthy Volunteers\]:

* (i) healthy volunteers that may be or not partner or carer of a Parkinson's patient;
* (ii) Subject aged ≥18 years and below 90 years of age;
* (iii) Patients off antibiotic or probiotic therapies for at least the last 4 weeks;
* (iv) Patients without formal diagnosis of dysbiotic conditions;
* (iiv) Subject with capacity.
```

## Locations (1)

- Charing Cross Hospital, Imperial College London, London, United Kingdom _(51.5085, -0.1257)_
  - Ilaria Belluomo, Dr — (CONTACT)
  - (CONTACT) — 020 7589 5111 — i.belluomo@imperial.ac.uk

## Central Contacts

- Ilaria Belluomo, Dr — (CONTACT) — 020 7589 5111 — i.belluomo@imperial.ac.uk

---

*Canonical: https://parkinsonspathways.com/trial/NCT06453226*  
*HTML version: https://parkinsonspathways.com/trial/NCT06453226*  
*Source data: https://clinicaltrials.gov/study/NCT06453226*