---
title: Reduce motor symptoms using neurofeedback
nct_id: NCT06582355
phase: NA
status: RECRUITING
sponsor: Maastricht University Medical Center
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06582355"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06582355"
last_fetched: "2026-05-10T14:08:20.745Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce motor symptoms using neurofeedback

**Goal (in five words):** Reduce motor symptoms using neurofeedback

**Official Title:** MOTOR-NF - a Randomized Controlled Trial of FMRI-based Neurofeedback for Motor Symptoms of Parkinson's Disease

**Trial ID:** [NCT06582355](https://clinicaltrials.gov/study/NCT06582355)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Maastricht University Medical Center
- **Target Enrollment:** 60 participants
- **Start Date:** 2025-02-10
- **Completion Date:** 2026-07
- **Conditions:** Parkinson Disease
- **Interventions:** Neurofeedback, Kinesthetic imagery
- **Intervention Types:** OTHER

## Summary For Families

It aims to help people with Parkinson's improve motor symptoms like slowness and stiffness by training the brain's motor networks. Using real-time fMRI neurofeedback plus kinesthetic imagery, participants watch live feedback of activity in their motor cortex and use imagined, felt movements to learn to increase or normalize that activity, a noninvasive brain-training approach that can be used alongside usual medications such as levodopa. They are enrolling adults 18 and older with Parkinson's in Hoehn and Yahr stages 1 to 3 who can safely have an MRI, score at least 24 on the MoCA, and have no history of psychotic or bipolar disorders, recent illegal drug use, or MRI-incompatible implants. About 60 people will be enrolled at Maastricht University Medical Center.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Diagnosis of Parkinson's disease.
* Disease stage 1-3 according to the Hoehn and Yahr Scale
* Age: 18 years or more

Exclusion Criteria:

* Exclusion criteria for MRI (e.g., cardiac pacemaker, certain metallic implants)
* History of psychotic disorder, bipolar disorder, or psychotic depression
* Current use of illegal drugs (any in the last four weeks)
* Current excessive alcohol consumption that interferes with daily functioning
* A score on the Montreal Cognitive Assessment (MoCA) below 24/30.
* Any disorder that would interfere with accurate and usable data acquisition.
```

## Locations (2)

- Uniklinik Köln, Cologne, Germany _(50.9333, 6.9500)_
  - Martin Kocher — (CONTACT)
- Maastricht University, Maastricht, Netherlands _(50.8483, 5.6889)_
  - David Linden — (CONTACT) — +31433881021 — pd-neurofeedback-np@maastrichtuniversity.nl

## Central Contacts

- David EJ Linden, Prof. — (CONTACT) — +31 43 3881021 — david.linden@maastrichtuniversity.nl

---

*Canonical: https://parkinsonspathways.com/trial/NCT06582355*  
*HTML version: https://parkinsonspathways.com/trial/NCT06582355*  
*Source data: https://clinicaltrials.gov/study/NCT06582355*