---
title: Reduce freezing episodes during walking
nct_id: NCT06630702
phase: NA
status: RECRUITING
sponsor: National Taiwan University Hospital
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06630702"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06630702"
last_fetched: "2026-05-10T14:07:10.616Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce freezing episodes during walking

**Goal (in five words):** Reduce freezing episodes during walking

**Official Title:** Application of Thoracic Epidural Spinal Cord Stimulation (SCS) for Managing Freezing of Gait (FOG) in Patients With Advanced Parkinson's Disease

**Trial ID:** [NCT06630702](https://clinicaltrials.gov/study/NCT06630702)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** National Taiwan University Hospital
- **Target Enrollment:** 5 participants
- **Start Date:** 2024-09-20
- **Completion Date:** 2027-12-31
- **Conditions:** Parkinson Disease, Freezing of Gait, Spinal Cord Stimulation
- **Interventions:** SCS electrode stimulation 1, SCS electrode stimulation 2, SCS electrode stimulation 3
- **Intervention Types:** DEVICE

## Summary For Families

The goal is to reduce freezing of gait in people with advanced Parkinson's who still respond to medication but keep having walking freezes that drugs do not stop. The approach is thoracic epidural spinal cord stimulation, which places electrodes in the upper back epidural space to send mild electrical pulses to spinal cord pathways that help coordinate walking. The stimulation aims to normalize gait-related signals so freezes happen less often or are shorter, it does not replace levodopa and can be used alongside your current medications. The trial is looking for adults 40 to 85 years old with Parkinson's for more than 5 years, clear drug response but persistent medication-resistant freezing, and no atypical Parkinsonism, major spinal problems, uncontrolled bleeding risk, or severe dementia.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 85 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Age:40-85 years old.
* Patients with primary Parkinson\'s disease who have been diagnosed by a movement disorder specialist for more than 5 years. Although they have a clear response to drugs, they have a frozen gait that cannot be controlled by drugs. Lower limb pain may be present with or without Parkinson\'s non-motor symptoms.
* No other secondary gait problems.

Exclusion Criteria:

* Atypical Parkinson's disease.
* Patients with spinal cord injuries.
* Medication-controlled frozen gait.
* It is expected that there are lesions near the implantation area causing spinal canal stenosis or myelopathy (can be ruled out by MRI).
* It is expected that the implantation area has undergone previous surgery or there is infection near the implantation area, which may affect the success rate of implantation or increase concerns about complications (such as severe extraspinal adhesion, or spinal cord damage in previous surgeries).
* People with abnormal coagulation function (such as hemophilia patients) or those who have been controlled by long-term use of antithrombotic drugs and cannot stop taking them in a short period of time.
* CDR (Clinical Dementia Rating Scale) ≧2. 8. Those who are allergic to developer.
```

## Locations (1)

- National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Hsinchu City, Taiwan _(24.8036, 120.9686)_
  - Kai-Hsiang Chen, M.D. — (CONTACT) — +886-3-5326151 — stanleychen1230@gmail.com

## Central Contacts

- Kai-Hsiang Chen, M.D. — (CONTACT) — +886-3-5326151 — stanleychen1230@gmail.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT06630702*  
*HTML version: https://parkinsonspathways.com/trial/NCT06630702*  
*Source data: https://clinicaltrials.gov/study/NCT06630702*